Conserved Protein Domain Family
DOCK_C-D_N
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pfam11878: DOCK_C-D_N (This model is not part of the current CDD release)
Dedicator of cytokinesis C/D, N terminal
This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases, required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorised into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11).
Links
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Statistics
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PSSM-Id: 519934
Aligned: 32 rows
Threshold Bit Score: 132.388
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015793400    36 PFIVEPLDYEELINKMRTILQNDPQRELVLFPMDDFEAKNITRAMRTIRPVpyndheimIPSkliDTnILPVSLhVRQCI 115 
XP_008101523   129 YDAVEPVDFEGFLMMQLNNLDSELLQELGDFPEDDLEVAFTPKEHRTLQPS--------LPE---EG-AELDPH-VRDCV 195 
18_pfamImport    1 YDAVEPLDLEEFFMSQLKSGDSALMQEFGDFPDDDLKVEQVEKECRTIRHS--------VPE---DG-VELDPH-VRDCI 67  
XP_006626930    57 YEAVEPVDLEEFLMTQLSSADSELMQELGDFPEDDLAVEFFPRECRTVQHS--------VPE---DG-EELDPH-VRDCV 123 
XP_046442972    63 NEALEPLDYEDVMNEHATASDRDPLKLLLSFPLDDLQLHLLPRPWRTLQPI--------TPP---EPlESLNSH-VRDCV 130 
XP_048582972    62 SEVVNPLDFEEFVLQNQPLNDNEPDAHMFDFPDDDIEVTTTPRHCRTVQPT--------IPK---DIsLDSDPH-LKDCV 129 
XP_011602407    50 TEVVEPVDFEEYVSSHAPGVEPGPLRQLTEFPQDDLELLPLDKECITLEPP--------LPD---DD-DSLDPR-VRDAL 116  torafugu
Q96HP0          48 TEVVEPLDFEDVLLSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPG--------IP----KDe-KLDAQ-VRAAV 113  human
XP_015146628    52 TEAVDPVDLEDYLITHPIAVESGPLRDLLEFPPDDIEVVYTPRECRTLVSA--------VPE---ES--EMDPH-VRDCV 117  chicken
XP_011613422    50 TESVEPVDFEEYLITHPPIVESGPLRDLIEFPQDDIEVIYSPRECRTVAQG--------VPE---EG--DTDAH-VRDCV 115  torafugu

XP_015793400   116 DGFLRDWSVIEFKYEKYSGSWTeLP-KLPRLNEEAN----LQDQVYEID 159 
XP_008101523   196 QTYVRDWLIVNRKNQGNNEVYT-FTkRGSRRDFHKT----LQKQTFESE 239 
18_pfamImport   68 KSYTQPWLVVSRRCQGDGWSVYsERtGL-----HKL----LRKQTFESD 107 
XP_006626930   124 QSYTQPWLTVSRRFQGDG-----WSiYSERTGLHKR----LQKQTFESD 163 
XP_046442972   131 RCYTSPWLVVQHRYQDFSSGSLaRQs-ASRLNALAA----TPRQEFEID 174 
XP_048582972   130 HTYQADWSIVNRRYQFRSAEED-KPdSRRRINRSRSfintLPKQIYESD 177 
XP_011602407   117 SVYTDDWLIIQRKYQHYSTTFTpHSs-ERQRERQRG----LAKQTFELD 160  torafugu
Q96HP0         114 EMYIEDWVIVHRRYQYLSAAYSpVTt-DTQRERQKG----LPRQVFEQD 157  human
XP_015146628   118 RSYTEDWAIVNRKYHKLGTGFNpNTlDK-QKERQKG----LPKQVFESD 161  chicken
XP_011613422   116 RSYTEDWALVNRRYHKLGTGFNpNTlDK-QKERQKG----LPKQVFEAD 159  torafugu
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