Conserved Protein Domain Family
DnaJ-like_C11_C
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pfam11875: DnaJ-like_C11_C (This model is not part of the current CDD release)
DnaJ-like protein C11, C-terminal
This is the C-terminal domain found in DnaJ-like proteins, including DnaJ homolog subfamily C member 11 (DNAJC11) from mammals and Chaperone protein dnaJ 13 from Arabidopsis. DNAJC11 is a mitochondrial outer membrane protein involved in mitochondrial biogenesis and in the response to microenvironment changes and requirements. The J-domain is mediated its mitochondrial localization, while this domain is critical for protein-protein interactions. This domain adopts a SUEL/RBL-like fold and contains the conserved motif FxDPCxxxxxK in common with the carbohydrate-binding loop of the SUEL/RBL lectin domain (pfam02140).
Links
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Statistics
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PSSM-Id: 519932
Aligned: 86 rows
Threshold Bit Score: 84.5714
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q57VU5        582 QNRLDHRTEMDVARVRATHEQKALQSSSLRSRMAEEQI---GGLVIINARYGVLQPRYpeslvlppkqpnaagnrsevsg 658 Trypanosoma br...
XP_002910260  450 AARLALEED-SDARKKRNAVVELLKDSARKVMSSETAR---GGLVIQNAVYGV--------------------------- 498
EPS97443      474 DARRALHEEKVELQRETKETVHLLQDIAKRHMDAEREC---DGLVILESLYGP--------------------------- 523
EMD34782      474 KVRRELREDKADLLRESKETTHLLQETARRHMQAETAC---DGLTIQEATYGP--------------------------- 523
XP_007394864  476 QARRELREAKADIVRAAEETVSLLRDTARRHTEAEASK---DGLVIVEARYGP--------------------------- 525
A0D406        404 HKIEEYQKFNEETRRNIEQG-----DNFQKALQFETDL---NGLIITLAYAGE--------------------------- 448 Paramecium tet...
XP_001023515  352 EKEAQYQKALEEKIKKRKGQLSLIEFQSQENNQYQINR---NGLIIIEGYYGNsqhikel-------------------- 408
13_pfamImport   1 RRHDMLVQYLAAARQNALEQQKLMLRCAKEKMEQERQRrdgRGLVIMLGRYGKDPTSPdplesqendldtvlqaieds-- 78 
XP_966193     145 YMLEKEADIIYANK------IEELKDIYEIKIKEEQNK---NGLIIEKALYGDlslkeec-------------------- 195 Plasmodium fal...
XP_002261467  156 RQLQMEAEVIYRNK------INEVKSIYLEKLQKEERK---NGLIIEKALFGNltlkeeh-------------------- 206 Plasmodium kno...

Q57VU5        659 rqrqtwwrfwragrgtptpsesvtvngkkkdegeETEGDSSSSVLVLDVTVPLQNFV--R--------DS-QLVL-PEG- 725 Trypanosoma br...
XP_002910260  499 -----------------------------------IDTEDGAHELAIDVTVPLQALV--R--------NS-QLYI-AGEg 531
EPS97443      524 -----------------------------------LERDEAAEGLDLDVTVALQALV--N--------RS-QLYI-PGRr 556
EMD34782      524 -----------------------------------AERDEGTEGLDVDVTVPLQALV--S--------KS-QVYI-PRG- 555
XP_007394864  526 ----------------------------------ADQNDESTKGLDVDVTVPLQALV--N--------NS-QLYI-PGGr 559
A0D406        449 ---------------------------------------LGDINQYIQNKVPNQYLSniKeqlqaeilDS-GLFIpPNCl 488 Paramecium tet...
XP_001023515  409 ---------------------------kesinraNYLHQNKARAEVIDVTIPLRFFQ-----------SKrGLNI--QTl 448
13_pfamImport  79 --------------emdfedgveaesgtgeritqQEVDGDVLVQKWIDVSVPLQFFV--K--------DG-ELAL--SCa 131
XP_966193     196 ---------------------------inncfniESISEQHLQGPYIDLTKILQCKV--E--------NS-SLLY-NDDf 236 Plasmodium fal...
XP_002261467  207 ---------------------------innclnmDVITENDLEGPFLDLTTILQARI--E--------NS-SFMF-NDEf 247 Plasmodium kno...

Q57VU5        726 SKSKLVGFTDPDP--------Ft--------rER---K---------------QLKIVYRFQRRRHVVILDDEDIVRLP 770 Trypanosoma brucei
XP_002910260  532 SKSNLQGFSDPAP--------F----------TP---K---------------SLRIHYLFNGRPHFAEIPDYLPVVLP 574
EPS97443      557 SKAGLQGFYDPVP--------G----------VA---K---------------VLRIRYTFRGSLHYAEIADWLPVVLP 599
EMD34782      556 DKAGLQGFYDPVP--------A----------AA---K---------------TLRVRYTFRGRTHYAEIPDYKPVVLP 598
XP_007394864  560 SKAGLQGFYDPVP--------S----------VG---K---------------SMRVRYIFRGHPHCAEISDFAPLVLP 602
A0D406        489 DK--LDGFFKVSS------------------------Kkns---------shyWGYVEYIYKGKAGNKKWNWAEPLSIG 532 Paramecium tetr...
XP_001023515  449 SKENLIGFFNPCR-------------------ENdcsK---------------SLLIRYSLYGQIFEQIYMDNKDVEIs 493
13_pfamImport 132 SKAGLLGFYNPCI--------G----------VD---QtiadarspsisgvtpSLYVRYAYDGQVFEASFDDDQAVNLP 189
XP_966193     237 SFAYFCDIPKPLIkisskqtkKklyshilqdtEM-------------------YLYIKYKFLNVYHELIVVDRSNFSLP 296 Plasmodium falc...
XP_002261467  248 SFAHFCGIPKPLIkip--crkDvsyadilqstEM-------------------YLYIKYKFLNTDHELIVVDRSRFTLP 305 Plasmodium know...
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