7TZO


Conserved Protein Domain Family
mTOR_dom

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pfam11865: mTOR_dom (This model is not part of the current CDD release)
Serine/threonine-protein kinase mTOR domain
This entry represents a domain found in human serine/threonine-protein kinase mTOR and its homologues, a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. In Saccharomyces cerevisiae, the TOR proteins, TOR1 and TOR2, regulate growth in a rapamycin-sensitive manner. This domain consists of HEAT repeats.
Statistics
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PSSM-Id: 519928
Aligned: 101 rows
Threshold Bit Score: 83.036
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7TZO_A        979 VVEPYRKYPTLLEVLLNFLKTE-Q-NQGTRREAIRVLGLLGALDPYKHKVNIgmi----------------dqsRDASAV 1040 human
XP_001564679  733 gTSPYVLYPRLFQQLCTVLHKT-EeSIDIRLEALRCIGVIGALDSHVFqsv--------------------nlsEEKADG 791 
Q57UT3        735 gRSPYEVYPHLYQQLSGIVKNN-DeDLDVRLEALRCAGVIGALDISIF-----------------------------HST 784  Trypanosoma b...
XP_001706690  944 VVFPWFIYHDLFTIVFGILKND-T-SQEIRLEAAKLITTIGAIDPIFYQNGK---------------------------- 993 
Q580A8        719 piteQSTHVSVYRALSRIIRGEaEeSEAVIYSAMKCLSVIGAVDPTKARYIVka-------------------------- 772  Trypanosoma b...
XP_001468732  730 tktdisglsEVYRAVARIIRREtEeEESVTIAAMKVLSSIGAVTPVKMRHVFrm-------------------------- 783 
Q4Q0C8        814 dVDVYETNPELLRVLLSALHGGfKeTWPVRLDVLKLMGIIGAVDPVRAKEITrhlr------------------------ 869  Leishmania major
Q38AC2        754 dVNVYEDHAELLPVLLQALHGGfKeLWPVRKDVLQLMGIIGAVDPVRVKEILrgsrvnn--------------------- 812  Trypanosoma b...
XP_651206     761 VVQPYYDYPELLGLLIELASNE-R-NQDIKIELIKVFGIIGAIDPYKYKLLT------------------------ETEG 814 
XP_001742706  370 VTLPYEDYPALMKTLYACYVEG-Q-STQIRLEAGRALGVIGALDPHREKSATgeaeaeaksnqakldaqqvsstVSQHAT 447 
7TZO_A       1041 SlseskssqdsSD---------YSTSEM----LVNM----------GNLPlDEFYPA--VSMVALMRIF----------R 1085 human
XP_001564679  792 V----------SA---------VVVDRVth-vKCCR-----------------------IVLRSVAALLdpeskrsagaR 828 
Q57UT3        785 V----------VNrtcrheemkRNEPSTlshaMCCR-----------------------VVIRSIASLLdlsekrfsggK 831  Trypanosoma b...
XP_001706690  994 ----------------------PDLSALvp-pTNLT----------CKCQsTDVFSLdyIMDES--NIWvchkgeggaaQ 1038
Q580A8        773 ---------------------lQEGEIAeeeeVATPalalykprlrIHLHmDERYPC--IVLYLLVKTL----------- 818  Trypanosoma b...
XP_001468732  784 ---------------------vESDEMEeeeeVVTPalahckprlrISTDmPERYPS--TVLYYLVRSL----------- 829 
Q4Q0C8        870 -------------------dggLSSSGAaapaALQL----------SSSRgEEAIAQ--NVVKNVLGVL----------Q 908  Leishmania major
Q38AC2        813 ---------------------------------------ntklvpfLPFEgEDTIAQ--TVVRSVLHIL----------S 841  Trypanosoma b...
XP_651206     815 A----------NQ---------NDDAETve-sLLPI----------SQAGtEEFYAM--TVIGLLLNIL----------R 852 
XP_001742706  448 A----------NA---------PDELQF------------------TIGS-EEYYMD--LAVRELYMIA----------Y 477 
7TZO_A       1086 DQSLS-HHHTMVVQAI-------TFIFKS--LGLKC-VQ--------FLPQVMPTFLNVIRVCDG-AIREFLFQQLGMLV 1145 human
XP_001564679  829 EGLLR-----TGVQTM-------LNIFEH----VPCsKS--------EISLVIGPLARVIRQLPGgRLFATVLFEFCNII 884 
Q57UT3        832 DNVLR-----VGIQTI-------LNIAES----CPDsRG--------EIAVVIPPVVRAVSELSAcRLLGTLLHELTQII 887  Trypanosoma b...
XP_001706690 1039 EASIK-SHGKAVVSPItghvvenVYIMK---LDSGSeVSanvsdfelTLNVIMSTLYSILS---EsTLDMYHYDAVVVFR 1111
Q580A8        819 QHSADvEQQASVISVI-------HSMIHE--VPGRQkAM--------LLTQFLPQLQAWLADPEKvHLYEVILLLMSDLA 881  Trypanosoma b...
XP_001468732  830 QLALDpKQQVDTLVAV-------RTMLHD--VEGKVkLN--------LLTQLLPQLQTWLRDPERaFLYETVLGLMNDLa 892 
Q4Q0C8        909 LPCLSdDQCLCAVQVI-------ANTLSLkeAASGClTP--------MYRDILHTVIQQITl--QaKIRENLFGLMTHIV 971  Leishmania major
Q38AC2        842 LPSLTeDQSVAAVQVI-------VGIFSLevLSPGClVS--------FYGEVISSIQKQARv--QvRKREEILVHLISLV 904  Trypanosoma b...
XP_651206     853 DNNLV-SGHEQTVKTF-------VKVICY--LNRKT-LP--------YIPQILSLYLKLFKTC-TiSVRPALIKGLADIM 912 
XP_001742706  478 SPAMDtNMHENLVHSL-------GTIVVK--SGIKL-VP--------YLPMIVPAFLHMVEHCNP-ARRHMLFKEISKIV 538 
7TZO_A       1146 SFVK 1149 human
XP_001564679  885 RYAg 888 
Q57UT3        888 RYVG 891  Trypanosoma brucei
XP_001706690 1112 TIiq 1115
Q580A8        882 TLLq 885  Trypanosoma brucei
XP_001468732  893 illc 896 
Q4Q0C8        972 YLyg 975  Leishmania major
Q38AC2        905 RILK 908  Trypanosoma brucei
XP_651206     913 YLIe 916 
XP_001742706  539 DIfg 542 
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