7NAF,8ESR,8FKQ,8FKR,8FKS


Conserved Protein Domain Family
DUF3381
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pfam11861: DUF3381 (This model is not part of the current CDD release)
Ribosomal RNA methyltransferase Spb1, DUF3381
This domain is functionally uncharacterised and it is found in the central region of fungal SPB1 and mammalian homologue FTSJ3. This domain is found associated with pfam07780, pfam01728. SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. FTSJ3, SPB1 homologue in humans, is associated with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing.
Links
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Statistics
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PSSM-Id: 519924
Aligned: 156 rows
Threshold Bit Score: 79.1193
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7NAF_w        236 PEKKVRKRQGYEEGDnl-lYHETSILDFVRTEDPISMLGEMNKFTIDEnd-----------------------hEWKi-L 290  Saccharomyces...
Q586Q7        234 VVPRSNVPAGYEEfat-vqQHVASFSEFMSSSDPKAFLRSHHELRFTT--------------------------PEEkaF 286  Trypanosoma b...
XP_004039999  240 IMQKRRKRVGYADDVkqtvFQAIPFAEFVNVNNPFAVFLTHNAISFNT--------------------------QVDknL 293 
A0EE91        284 VSRTQRHRSGYADDVhqtvYQMINFEEFLHAENPYPIFIEYAGIKMTE--------------------------EAKqkY 337  Paramecium te...
A0EER5        232 VSRTQRHRSGYADDVhqtvYQMIDFEEFLHAENPYPIFIEYAGIKMTE--------------------------EAKqkY 285  Paramecium te...
XP_001321439  224 LIAKHAVPSGVETKMtsidYSTISVSEYLRAEKPLDILTTANKLVFGDd-------------------------PVSqaA 278 
Q4U8L6        269 KEQKKINREGYEGPI----YSEISVIDFLKSKEPAVILVTYNKLLFTTtnsntig-------------tkstdeEILemV 331  Theileria ann...
Q8IDF8        274 KEKKKKNRQGYDVGDd---YRATDICTFIKSDNYVDLLIKNNKFTFDKnyknns---------------dpmikTIYecI 335  Plasmodium fa...
Q4N1B5        247 KEQKKTNREGYDGAI----YSEISVIDFLKSKEPATILVTHNKLLFTTthncinsnhnsvnssinsttgtigddDVLsmV 322  Theileria parva
XP_001616328  264 KEKKKKNRQGYDLGDd---YRVTDICNFIHSDNYVDLLIKTNKFTFDKdyltse---------------dplvkSTYtaI 325  malaria paras...

7NAF_w        291 KKLKQTTDEFRSCIEDLKVLGKKDFKMILRWRKIAREILGIEVK-DDAKt------------------------------ 339  Saccharomyces...
Q586Q7        287 LKSKHSKKELVYLCGDLQQVGDADLRRLVRWREQLLREQARELKqRAASdanagdiaeedee------------------ 348  Trypanosoma b...
XP_004039999  294 LNVAQGPEDWKELCEDILVLGKRDIAKLIKWRNKIQHSQKKQRQqLKATsgkqneensendqiseiee--------idey 365 
A0EE91        338 LSLAKPPQDYEILMEDIKVLGKREIIQLLKWRSKIKHFISKQKKeQEQLeqqeqqesaeyed------------------ 399  Paramecium te...
A0EER5        286 LGLAKPPQDYEILMEDIKVLGKREIIQLLKWRSKIKHFLSKQKKeQKQLekqeqqesaeyed------------------ 347  Paramecium te...
XP_001321439  279 LNHPQTTNEIKTLLSDLKLVGFSDRKVLLKWRNKLRNLLVLGNAgEEEKvee---------------------------- 330 
Q4U8L6        332 KENPLTTEEIKLLCSDLKVAGKSDLQSLLKWRFKLINTIPNLKTkSNPSdstkpgidgs--------------------- 390  Theileria ann...
Q8IDF8        336 YKNECTTKEIFFLCNDLKVLGKSDLYNLIKWRYKIKKSVL-----NQTSkknnldfdnhdveqttqelsdvkessqiddf 410  Plasmodium fa...
Q4N1B5        323 EESPLTTEEIKLLCSDLKVAGKSDLQSLLKWRFKLINSIPSLNRkSSEQseslkpedesvaetkst-----------snk 391  Theileria parva
XP_001616328  326 YKNPSTTQEILQLCKDLKVLGKSDLFHLIKWRYKVRKGVASLGGeTQLSktsdaeeeasqgvdpvkenl------pteet 399  malaria paras...

7NAF_w        340 -------------eIEVVPL---TEEEQI---EKDLQGLQEKQRLNVKRERRRKNEMKQ--------KELQR 384  Saccharomyces cerevis...
Q586Q7        349 ----------eekdddkfdfdsaEGVAKI---ARELLELRKKQSKEMKKKQKKIVDRKL--------KQIKG 399  Trypanosoma brucei
XP_004039999  366 eensgneeasendeISEEEEeekEEKDEI---SNSNSDLQKEIQEVQKQELNKQRKQRAkqakelqkQAVTS 434 
A0EE91        400 --ldeaegegeddeVNEEEAveqDDLDKLv--DKQKEALEQQYIEEQKKELKEQRKQKQ--------KQAQQ 459  Paramecium tetraurelia
A0EER5        348 --ldeaegegqddeVNEEEAeeqDDLDKLv--DKQKEALEQQYIEEQKKELKEQRKQKQ--------KQAQQ 407  Paramecium tetraurelia
XP_001321439  331 --------------------ekkEEEEEVdesDEEIQAAMAELKAKRRKEEKAARRHKA--------KLRDQ 374 
Q4U8L6        391 ----eptisdttvsTTTDPTamdTVDSTI---DSTVIEMDKKIKNKIESEKRRLERKQR--------KMLKK 447  Theileria annulata
Q8IDF8        411 ntivdkniseneldNTSDEAtekDEKDQV----DEIEEFSAYIEKKKKKEQKKKEKKLK--------KELEK 470  Plasmodium falciparum...
Q4N1B5        392 stsdkstsnkstssKSTSNEsveIDPEAV---DSSVLSLDKKLKSKIIQEKRRLERKQR--------KMLKK 452  Theileria parva
XP_001616328  400 rtattkaslqddelSGSSDA---DSEK------DEINEFSTQMEKKNKKEQKKKEKKLK--------KELEK 454  malaria parasite P. v...
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