Conserved Protein Domain Family
DUF3350
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pfam11830: DUF3350 (This model is not part of the current CDD release)
Domain of unknown function (DUF3350)
This domain is functionally uncharacterised and is found in eukaryotic proteins, such as TBC1 domain family members 1 and 4. This presumed domain is typically between 50 to 64 amino acids in length. TBC domain proteins may act as GTPase-activating proteins for RAB2A, RAB8A, RAB10 and RAB14.
Links
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Statistics
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PSSM-Id: 519905
Aligned: 12 rows
Threshold Bit Score: 78.4193
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005586058  793 ELLPLSPLSPTMeeeplviflsgeDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLE 856 
XP_049529336  807 SEEYMSPFRTPG------------DHQQTTKKKRTREELRELWRVGIKQTIILNRMDKENAHLQ 858 
Q7PML2        646 SDEYMSPLRAVG---------------GAPAKKRTREELRELWRVGIKQTIILSRMEKENAHLQ 694  Anopheles gambiae str. PEST
XP_069047801  683 EAPPRAALGPGLce--------glLGPVAEERKRTRQELRELWRKAILQQILLLRMEKENQKLQ 738 
EHB16223      557 ELPPRSPLEPVCed--------gpFGSVAEEKKRTSRELRELWRKAILQQILLLRMEKENQKLQ 612 
6_pfamImport    1 ELLPLSPRALDPrqdalagllpseQSTGGETGCRTPADYRALWKKAIHQQILLIRMEKENQRLE 64  
7_pfamImport    1 ELLPLSPLAPALekdplaallqpeEAFVEKRPRHTAEDLRALWKKAIHQQILLLRMEKENQRLE 64  
XP_011605155  694 ELLPLSPHSRRSvmdp-----srhLLPPGEKPKRTSADYRALWKTAIHQQILLLRMEKENQRLE 752  torafugu
XP_029707391  667 lrvatpqkstenidcvntpdgrqvgNVQEKKLNRSKDELRELWRTAIKQQILLQRMEKENLKLK 730  torafugu
XP_014344794  601 DLLPLSPLTPAVeedplasllqsdDDTDGEKKKRSSEELQCLWRKAIHQQILLLRMEKENQRLE 664  coelacanth
XP_056717866  418 ELLPLSPLAPSLeedplasilqndDSQDNTGEKKNSEELQSLWRKAIHQQILLLRMEKENQKLE 481  tarantolino
XP_028913836  645 ELLPLSPLAPTMeedplalflpdeDVPEKAGGKQHSEELRSLWRKAIHQQILLLRMEKENQKLE 708  platypus
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