3DZU


Conserved Protein Domain Family
Nuc_recep-AF1

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pfam11825: Nuc_recep-AF1 
Nuclear/hormone receptor activator site AF-1
Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif.
Statistics
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PSSM-Id: 403126
View PSSM: pfam11825
Aligned: 20 rows
Threshold Bit Score: 71.7607
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DZU_A        22 SSLTSPTGRGSMAAPSLHPSLGP-GIGS------PGQLHSPIST--LSSPINGMGPPFSVISSPMGP--HSMSV-PTTPT 89 
Q0VJ96        18 SSLSSPTGRGSMAAPSLHPSLGPgLGSPlg---sPGQLHSPIST--LSSPINGMGPPFSVISSPMGP--HSMSV-PTTPT 89  Norway rat
2_pfamImport   1 SPLGSPTSHRGM-----HPSLL----SPtsm-gpSGSLHSPIST--LSSPMNGLASPFSVISSPMGPplHELTSvPSVLA 68 
XP_007243934  56 SPLSSPTGHRGMGPHPLHPSLL----TPssmgstPGHLHSPI---------NGLASPFPVISSPMGH--PSMTG-PSSTS 119 Mexican tetra
XP_011615675  13 SSVSSPPS------GQRSPPLVPsAAAS------MTSLP-PITTtgVSSPISSIDSPFSVISSSMGS--PCL---PGTPS 74  torafugu
XP_004027871  25 TSMSPSAALSTVKPMDSHPSYTDtPVSA------PRTLS----A--VGTPLNALGSPYRVITSAMGP--PSGAL-AAPPG 89  western lowland...
XP_012403075  25 TSMSPSPALATGKSPDSHSNYIEaPVSV------PRTLASPLNA--IASPLNALGSSYRVITSAIGP--HSLSL-ATSPG 93  Tasmanian devil
XP_006640727  61 TSLSSPNSHRAMNTPTLHPSLMGsGISPssl-gsSGQLHSPIST--LSSPMNGLGSPFSVISSPMGP--HSMSV-PSTPG 134 spotted gar
AAI21596      10 TSVSSSSNLAAMNSLDVHTGYMGnSMNG------PRSMTTNMNS--LCSPGNNIGPPYRVIASSMGP--HSL---PSPTI 76  tropical clawed...
XP_004916703  18 SSLNSSGLRGSMTAPLLHPSLGNsGINnsl--gsPTQLHSPL---------NGMGPPFSVISPPLGP---SMPI-PSTPG 82  tropical clawed...
3DZU_A        90 LGFSTG-SPQLSSp-----MNPVSSSEDIKPPLGLNGVLK-----VPAHPSGN 131
Q0VJ96        90 LGFGTG-SPQLNSp-----MNPVSSSEDIKPPLGLNGVLK-----VPAHPSGN 131 Norway rat
2_pfamImport  69 LTFFTG-RFQLNSp-----MNSVSSTEDIKPPLGINGVMK-----VPAQPSGT 110
XP_007243934 120 MAFGPSlSPQLSSp-----MISVSSPEDIKPPLGLNGVMK-----VPAQPTGT 162 Mexican tetra
XP_011615675  75 VGYGPIsSPQINStvsmsgLHAVSSSDDVKPPLGLKQLSS--------HSQGP 119 torafugu
XP_004027871  90 INLVAPpSSQLNV------VNSVSSSEDIKPLPGLPGIGNm---nYPSTSPGS 133 western lowland gorilla
XP_012403075  94 VNMVGPpSSQLNV------MNNVRSSDDVKPLPGIQGMGTm---sYPSTSPGS 137 Tasmanian devil
XP_006640727 135 MGFGPSvSPQLNSp-----MNPVSSSEDIKPPLGLNGVMK-----VPAQPSGT 177 spotted gar
AAI21596      77 LNFPGHeSPPFNL------MNNISCSEDIKPPPGLSNLGSpcmnnYSCNSPGA 123 tropical clawed frog
XP_004916703  83 LGFGTG-SPQIHSp-----MNSVSSTEDIKPPPGINGILK-----VPAHPSGP 124 tropical clawed frog
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