pfam11825: Nuc_recep-AF1 (This model is not part of the current CDD release)
Nuclear/hormone receptor activator site AF-1
Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif.
Jiyao W et al.(2023). "The conserved domain database in 2023.",