Conserved Protein Domain Family
BTB_SANBR
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pfam11822: BTB_SANBR (This model is not part of the current CDD release)
SANT and BTB domain regulator of CSR, BTB domain
Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.
Links
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Statistics
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PSSM-Id: 519901
Aligned: 7 rows
Threshold Bit Score: 151.862
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4DXB1        30 VEVTVYDKLLNEVRTFRCHQHLLETSMAYFEPIIRRyleeeaeeekkriraeiekgrdsisgasaatnletsigvtdgsa 109 Trypanosoma cruzi
XP_002939550 146 MVIHVCDEAKNLKEDFVCPRDLLVSEMKYFAEYLST-------------------------------------------- 181
EDO39893       1 MVIHVCDESKNLKQDFTCPRDLLIREMRYFAEYLSV-------------------------------------------- 36 
Q4Q8A2        20 VEITVQDPATHHERPFLCALGPLRTHMRYFEPLIQRqi------------------------------------------ 57  Leishmania major
XP_001566211  10 AEITVQDPVTHNERTFLCALGPLRTHMRYFEPLIQRqm------------------------------------------ 47 
Q383Z9        26 VEVSVYDKQSNEMRVFRCDLHLLESSMTYFTPIIKCyldeeerqksreeksldrasst---------------------g 84  Trypanosoma brucei
XP_029691601 134 MLIHVCDETKNLKQDFTCPRDLLVKEMRYFAEYLSV-------------------------------------------- 169 torafugu

Q4DXB1       110 drkaiigtrgqgdvgpssrisGNTPLPP----------IPIRVNCDLSIFSWLMAYIQG-----------KDRPFTPENA 168 Trypanosoma cruzi
XP_002939550 182 ---------------------DAQRWEE----------VDISVHCDVHIFDWLMRYVKRsape---nenqEAPKLEPGNV 227
EDO39893      37 ---------------------EAQRWEE----------VDISVHCDVQIFDWLMKYVKKglmekgkkvdeKPPKLEPNNV 85 
Q4Q8A2        58 --------------------nEAKVSPPpesssslavaFTLRARCEHATFQWLINWISG-----------KAPQITNSNV 106 Leishmania major
XP_001566211  48 --------------------sETTVWPPsaspsssavaLTLRARCDHVTFQWLVNWMSG-----------KTQEITKDNV 96 
Q383Z9        85 arsvknsktkaheatkplkrkGKEEKPP----------IPLHVNCDMSTFSWLMAYVEG-----------KQRSFTPKNA 143 Trypanosoma brucei
XP_029691601 170 ---------------------DTQRWEE----------VDISVHCDVQIFDWLMNYVRRnsag----eskDKPRLEPSNV 214 torafugu

Q4DXB1       169 VSIALSSNFLLMTQLVDLPL 188 Trypanosoma cruzi
XP_002939550 228 ISILISSEFLKMDSLVDKCI 247
EDO39893      86 ISILISSDFLKMDNLVNDCI 105
Q4Q8A2       107 VSICLSSSFLQMQELSDNAL 126 Leishmania major
XP_001566211  97 VSICLSSSFLQMQELSDNAL 116
Q383Z9       144 VSLALSSNFLHMTQLVEMTL 163 Trypanosoma brucei
XP_029691601 215 ISILISSEFLKMDTLVEECI 234 torafugu
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