7XHO


Conserved Protein Domain Family
CENP-K

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pfam11802: CENP-K (This model is not part of the current CDD release)
Centromere-associated protein K
CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.
Statistics
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PSSM-Id: 519893
Aligned: 13 rows
Threshold Bit Score: 224.623
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7XHO_K        10 STTDVGDVTNTEEELIRECEEMWKDMEECQNKLS---------LIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPE 80  human
3_pfamImport   1 SSTDVRDITDSEQELVKECEEMWRDMEEYQNKLS---------LIGTKTLTDSNAQLSLLILQAKCLTAELRQWQKETPE 71 
EHB02756      10 STTDMEVVTDIEEELIKACEEMWKDMEECQNKLS---------LIGAETLSNSNAQLSLLIMQVKCLTAELSQWHKETPE 80 
2_pfamImport   1 NTTDVDQVTDAEKKLIKECEEIWKDMEECQNKLS---------LVGTETLTNSNAQLSLLIMQAKYLAAELSQWQKETPK 71 
Q9ESN5        12 TITDVEAVIDTEEELIKECEEMWKDMEDCQNKLS---------LIGTETLTNADAQLSLLIMQMKCLTAELGQWKKRKPE 82  house mouse
XP_003759448  12 DILDKEYVMDRKDRIIEECEELWKQMEKYQQEIT---------LAEGERLNCSDAQLTLLMMRLKNLTAEYNQWLERTPD 82 
XP_007486453  12 DIENKEYIVDRKDKLIEECEELWKQMEKCQQEIA---------LAGGERLNHSDAQLTLLMMRVKSLTAECNQWLERTPD 82 
O94494         1 ---MNSENASLFRNILNDTENLVQPLTQDESRLA---------LF--ESLVQSD----------QLLVEKIEKWEKKVSK 56  Schizosaccharom...
XP_001628227   5 ENSSVTEKTSYMQDLKDQCEGLWLHIHQTHARLRsraenmtcfLPGEENL--EKIHEEILKAKEKRLQAEYAAIESSGVE 82 
XP_005997501  29 LTANGQRSAEAKEILVQECEVVWREMEECQRKLS---------LLEPEALLDSDVQLSVLMARVKALMAEHNQWQNRKPD 99 
Q9BS16        10 STTDVGDVTNTEEELIRECEEMWKDMEECQNKLS---------LIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPE 80  human
XP_031749902  29 ISKTSQAPEEAREELLQQCEEIWKQMEECQSKLT---------MSGPETLPEMDVQLYLLMMQVKALTAEYEQWQKRTPE 99 
XP_057350845  12 STTDvEDVTDAEKELIKKCEEMWKDMEECQNKLS---------LVGTETPTNSNAQLSLLIMQVKCLTAELTQWQKETPE 82  Chinese pangolin
7XHO_K        81 T-IPLTEDVLITLGKEEFQKLRQDLEMVLSTKESK---------------------------NEKLKEDLEREQRWLDEQ 132 human
3_pfamImport  72 I-IPLTDDVLTTLAEEEFQKLRHDLEMVLSTIQLK---------------------------NEKLKEDLEREQQWLDEQ 123
EHB02756      81 N-CSISFPFGVALGDLEFQKLSHDLEMVLSTIQSK---------------------------NENLKEELEREQQWLDEQ 132
2_pfamImport  72 SkILISLFVLYTIILFQFQKLRHDLEMVLSTMQSK---------------------------NEKLKEDLKREQQWLDEQ 124
Q9ESN5        83 I-IPLNEDVLLTLGKEEFQKLRCDLEMVLSTIQSK---------------------------NEKLKEDLEREQQWLDEQ 134 house mouse
XP_003759448  83 I-IPLNPESLITLGKEELQKLHHNLEMLLSTVQSK---------------------------NQQLQEDLRREQEWLNEQ 134
XP_007486453  83 I-IPLNPESLVVLGKDELQKLDHNLEILLSTIQSK---------------------------NQKLKEDLTREQEWLNEQ 134
O94494        57 F---------TENSKSEKRKL--QLELFQEIIDLKkciafkpiigknaidnnisdlkknlhsNKKLEAVLKEELHQIKKF 125 Schizosaccharom...
XP_001628227  83 V-PSMKEEYLDASLKQQLAQNTSQLDDTLLILKSK---------------------------RKEIAEQLEREKEILEQH 134
XP_005997501 100 V-LCTNPEVLVTLGKEEIQKVNKELEMVVSCVLMK---------------------------NKKIREDLEREQKWLAEQ 151
Q9BS16        81 T-IPLTEDVLITLGKEEFQKLRQDLEMVLSTKESK---------------------------NEKLKEDLEREQRWLDEQ 132 human
XP_031749902 100 I-ISDNQDVLLAVGKEELDKVARELEMVLSSVQAK---------------------------NKKLKKDLEKEQNWLDGQ 151
XP_057350845  83 I-IPLNEEVLVTLGKEKFQKLRHDLELVLSTIQSK---------------------------NEKLKEDLEREQQWLDEQ 134 Chinese pangolin
7XHO_K       133 QQIMESLNVLHSELKNKVETFSES-RI----FNELKTKMLNIKEYKEKLLSTLGEFLEDHFP-LPDrs---vkKKK---- 199 human
3_pfamImport 124 QQIMESLNVLHSELKNEVVPFSESrRG----GGKIEELMINMVKRKEDLGLLIGWKWNNIYS-LQS-------KKK---- 187
EHB02756     133 QEIMKSLNVIYSELKKQVVTFSES-RI----FNELKTKILYIKEFKEKLLITLGEFLEDHFP-LPNgt---lkKKK---- 199
2_pfamImport 125 EQILESLNRVYNELKNQVVPFSES-RI----FNELKTKMVNIKEYKEKLLFTLGDFLEDHFP-LPDge---vkKKK---- 191
Q9ESN5       135 QQILDTLNVLNSDVENQVVTLTES-RI----FNELTTKIRGIKEFKEKLLLTLGAFLDNHFP-LPEas---tpKKR---- 201 house mouse
XP_003759448 135 EELGASLNEMCKELKNQVIPVSEK-RT----FLEMKTKMTKIKKHKEKLLTSLGEILDKHFP-LPEen---gsKKR---- 201
XP_007486453 135 EHLVTSLSKKCKERKNQVIPFSEQ-RT----FFEMNTKMTKIQSQREKLLNSLGEFLDKHFP-PPEen----gnKR---- 200
O94494       126 SSDLQSLKSSMGERQKQQAAMSRRgKKsiihSAIIQEKERYEKE-SQELFTFLDGFLDEHAPsLLEgaqasidKNR---- 200 Schizosaccharom...
XP_001628227 135 KDIEISLLNKTKKIEDTKENFQSGtSK----VRELERKQRIAETQLKQVMKKLGVFLREHFP-LPTledvevkRKTvlqg 209
XP_005997501 152 QELVKALAERHQALKTDVVQLSEK-RA----LQELGGKIQKIKVYQEELLIALGTFLEDHYP-LPKqwgnaskKKK---- 221
Q9BS16       133 QQIMESLNVLHSELKNKVETFSES-RI----FNELKTKMLNIKEYKEKLLSTLGEFLEDHFP-LPDrs---vkKKK---- 199 human
XP_031749902 152 QKLVDALTSRQDELKNQLSTFSEK-RV----FQDIANKLFKVRAYKEELLSALGDFLEEHFP-LPEeqenqskKKK---- 221
XP_057350845 135 QQILESLNVLHNELKHQVVTFSES-RI----FKELKSKMCDIKEYKEKLLITLGEFLEDHFP-LPDrn---vkKKK---- 201 Chinese pangolin
7XHO_K       200 KNIQESSVNLITL---------HEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ 269 human
3_pfamImport 188 KNVQEPTAQLITL---------HEMLEILINRLFDVPYDPYVKISDSFWPPYIELLLRNGIALRHPEDPTRIRLEAFHQ 257
EHB02756     200 KNIQEATKQLITL---------HEVLEILINRLFDVPHDPYVKISDSFWPPYIELLLRNGIALRHPEDPTRIRLEAFHQ 269
2_pfamImport 192 KNIQEPTAQLVTL---------HEMLEILINRLFDVPHDPYVKISDSFWPPYIELLLRNGIALRHSEDPNRIRLEAFHQ 261
Q9ESN5       202 KNIQDSNAQLITL---------NEILEMLINRMFDVPHDPYVKIRDSFWPPYIELLLRYGIALRHPEDPSQIRLEAFHQ 271 house mouse
XP_003759448 202 KRECQPNAQLITL---------HEILEILINALLHSPHDPYVKINDSFWPPYIELLLRTGIVLRHQDDPSQIRLEAFHQ 271
XP_007486453 201 KRECKPTAQLKTL---------REILEVLINSLLRSPYNPYVKIDDSYWPPYIELLLRNGIALRHQDDPNQIRLEAFHQ 270
O94494       201 PGKNQPSLNFENIskkdlteefKQVIENLMNNSI-IPGSPYIEVKNE---RIVSFLVLASLCTVDPQDPSKVKLIPFSD 275 Schizosaccharomy...
XP_001628227 210 EQTLDPTINYVTL---------QEMLEELMNTQHDRPHDPYMQLQPHHWPPYVELLLRCGLVLRHNQDSNQIKLESF-N 278
XP_005997501 222 TQVDEPCLYLITL---------HEILENLINKLMISPHDPYITIDDSYWPPYIEFLLRYGIALRHPEDPHRIRLEAFHQ 291
Q9BS16       200 KNIQESSVNLITL---------HEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ 269 human
XP_031749902 222 GQSGKKTVPLMTL---------HEILEILINKLMTTPHDPYIVIEPHHWPPYIEMLLRYGIALRHPEDPNRIRLEAFHQ 291
XP_057350845 202 KNTQESTVQLITL---------HEMLEILVNRLFDVPHDPYVKISDSFWPPYIELLLRHGIALRHPEDPTRIRLEAFHQ 271 Chinese pangolin
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