3K1L


Conserved Protein Domain Family
FANCL_C
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pfam11793: FANCL_C 
FANCL C-terminal domain
This domain is found at the C-terminus of the Fancl protein in humans which is the E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia) that mediates monoubiquitination of FANCD2. This entry represents the RING domain which recruits the UBE2T ubiquitin conjugating E2 enzyme as other RING E3s.
Links
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Statistics
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PSSM-Id: 492109
Aligned: 6 rows
Threshold Bit Score: 114.862
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3K1L_B       307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376 fruit fly
Q8T913       307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376 fruit fly
XP_048586353 304 FSMECGICYAYRL---------NDTIPDKACDDPRCGQPFHRDCLYEWLRSLPSSRQSFNMVFGECPYCSKPITVKMT 372
Q9CR14       303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371 house mouse
XP_001315697 268 TEIECPICFCERF---------GGELPEIVCENPKCAKHYHRSCLVDWLRENRKMEQSFHCIYGTCPNCGAKIQVDDS 336
NP_201375    137 QQVECGICYAQFLptdeelgarSGTRTDYTCENISCNKSFHSLCLTDWLRSITTTRQSFDVLFGNCPYCSDPVAVKTS 214 thale cress
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