Conserved Protein Domain Family
GAPT

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pfam11770: GAPT (This model is not part of the current CDD release)
GRB2-binding adapter (GAPT)
This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.
Statistics
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PSSM-Id: 519874
Aligned: 12 rows
Threshold Bit Score: 196.519
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023481413   1 MLKNCGNTSAAIAIGISLLL-LLVICGIGCVWHWK-QRNTTQFSLPKFLQRRSSRRK-DYTKTVSLSPYVINSRHKISVQ 77 
2_pfamImport   1 ILRKCGNDSGLVLLIVFLLLaILVLGALGLTLFWKhRHYISNVALPRFLHKKKDQNEsDSPHIPCTLAEYVDAKSFSPFQ 80 
EFB29490       1 MLKSCGNTSVATSIGISLLF-LLLICGIGCVWRWK-HWNPMQFTLPRVLQRRSSRKK-DYTKTLS-SLLAISSRNKISVQ 76 
XP_006906105   1 MLKSCGNTSMAIPIGISLLL-LLLICGIGCVWHWK-HRNQTQFTLPRFLQRR-SRKK-DYTKTLILGPHISSSKNKTSVQ 76 
XP_008950998   1 MSKSCGNNLAAISVGISLLL-LLVVCGIGCVWHWK-HRVATRFTLPRFLQRRSSRRK-VCTKTF-LSPRIIGLRHEISVE 76 
XP_003782793   1 MLKSYGNTSAAILVGAALLL-LVMICGIGCVWHWK-HNDSMRFTLPKVLQRRSSKKK-DYTKTSILSPRIFGLKHNTSVE 77 
XP_035315319   1 MLRSFVSSSMGVAVGVALLV-LLLACGIGCAWHCK-RQEATAFTLPKFMQRRSSRHK-NFTKNLGLNVHTICPSSKTSVE 77 
Q8CB93         1 MLECFESSPVAVAVGVSLLV-LLLLCGIGCAWHWN-RRESTPFTLPKFMQRRSSRQK-DVTKTVSSSAYVISPSMKASVE 77  house mouse
XP_003408099   1 MLKSCGDTSVAFSIGIFLFL-LVVFLGIGCFWHWK-HPDTTRFTLPKFLRRRSSKRN-NYAKTPSLSSQVIGPKHKISAQ 77 
XP_008260459   1 MLTSRGNPSVAISIGISLFL-LLVVCGIGCLWHWK-HRDSTGFTLPKFLQRRSSKKK-DCKKMF-FSPHIINAWHKISAE 76 
1_pfamImport   1 MLKICGNTSVAVSIGIFLLL-LLVICGIGCVWHWK-HQNTMRFTLPKFLQRRRSRKK-DYTKTFSLSPQFIGPRHKTSVQ 77 
XP_020932514   1 MLKSCGNHSVGISIGISLLL-LLAICGIGCVWHWK-HCNTMRFTLPKILQRRKSKRK-DCTETLS---QVI--RHRISVQ 72 
XP_023481413  78 TQDHRSAVRGTDIHGNYENVKVSPLNAKEETEKELYQNIQQCNLEEHIYGNEAPSKYCNFQNLHTSE 144
2_pfamImport  81 IKDEPSPLSKGDMDHNYENMAIGSKSCAEECLTDLYENTAQFNSEEHLYGNESSPEYYNFQKPHFPQ 147
EFB29490      77 NQDCRTSGRGTNTHDNYENVERGAPKPKEETDKELYENIRQTSFEEHIYGNEMSSQYYNFQKPSTSE 143
XP_006906105  77 SQGHKSAMEETDIYDHYENVETRPPEAKEETNKELYENTRQTNIEEHIYGNETTSEYYNFQKPSTSE 143
XP_008950998  77 TQDHKSAVRGNNIHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSE 143
XP_003782793  78 TQRCSSTVEGNNIQENYENVQTGPPKAMEETDKELYENTRQSNFQDHIYGNETSSEYYNFQKPSTSQ 144
XP_035315319  78 SKGHKSSAKRNRMHGEYENVEVGPPDTKVATEKALYENTQPSNLEEHVYGNQTDALYYNFQKPSPPP 144
Q8CB93        78 SKGHKSTAKRNKMHGNYENVEVCPPCTEGTTEKALYENTQPSNLEEHVYGNQTDPLYYNFQKPSPPP 144 house mouse
XP_003408099  78 TQDHRSAMGKTTIHGNYENVEVRPPKAKEETDKEIYENTRQSSFEEHIYGNQTSSDYYDFQEPHTSE 144
XP_008260459  77 VHDHRSAVGETNLNDNYENVEASCPRTKEETDKELYENTRQCDFEEHIYRNETASEYYNFQKPIASR 143
1_pfamImport  78 TQDRHSAGKDTNIHDNYENVKVCPPKAKGETDKKLYENTWQTNPEEHIYGNETPCDYYNFEKPSTSE 144
XP_020932514  73 TQDHSFSGKDTNICDNYENLEVGPPEIKEKADKELYENTCQTNFEEHIYGNEKPCDYYNFQDPSTFE 139
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