Conserved Protein Domain Family
N-SET

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pfam11764: N-SET (This model is not part of the current CDD release)
COMPASS (Complex proteins associated with Set1p) component N
The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes. This domain promotes trimethylation in conjunction with an RRM domain and is necessary for binding of the Spp1 component of COMPASS into the complex.
Statistics
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PSSM-Id: 519871
Aligned: 66 rows
Threshold Bit Score: 133.568
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003668713  771 KKSIDILDFQEVIKDTEDISILQELLDAnetKPTEEMKHAGcISEYAIWKYRENEKNL------RLTNEWH--LN----- 837 
XP_003687088  707 SKVLSISQFQDLIKDTEDIKILKSILDT---YETKNNFSPY-LLEYLLWKSNENRQNF------DQATAWQ--TQ----- 769 
CCH60348      892 SLKLNIHDLQNAVKDEEDLELLKSIVGA---NVEKSNPAYTtLIEYDCWKDRRQSINK------KASTDTY--KL----- 955 
Q7QKB2         15 GILFDF--LTRGV-DAEDVRYIRQSYDM---LLMDDASSYWlNATHWVDHCATDRNFEpa--llAPPPSKRrkKD----- 81   Anopheles gam...
6_pfamImport    1 GILYKI--WEAGL-DVEDMKHLRHVYEE---MLATPGEMGWvNDTHWVPHPTTHIPTDddvtglSPTKRGRrkRRqskkd 74  
XP_007255047 1357 TILYDI--WNDGI-DEEDIKYLKITYDK---LLQQDNVNDWlNDTLWVHHPTTSGGSL--------PGLKK--KR----- 1415
XP_012809767 1451 TILYDI--WNTGL-DFEDMVFLRDTYER---LLQEDHSTDWlNDTHWVHHPITNIADP----------KRR--KN----- 1507
XP_005469029 1920 TILYDI--WNSGL-DGEDLLFLKKTYEK---LLQDDHSSDWlNDTHWVNHTITNLPNP---------RRKK--KN----- 1977
XP_008113606 1644 TILYDI--WNSGL-DLEDMKYLRLTYER---LLHEDNSTDWlNDTHWVHHTITNIANP-----------KR--KR----- 1699
XP_026690140 1606 RMMYNI--WDRGL-DVEDMKYLRQEYED---MLANPGTGGWvNDTHWVPHPATYFPDEnda-ltTSPDKRNkrKR----- 1673 vase tunicate
XP_003668713  838 LNev---pfDVELTKGKGSFKAEGFRKIPDNLKACYL-PHRRKLNQPLNTVNQHGSDRPTGNKFTPEpsarreesndPDA 913 
XP_003687088  770 LNga---pfDYSLLPKDTAFKANGFFTVSDKHKNSYL-PHRRSLHTPLNTVNHHNESLVKQDHITKEss-------vEPD 838 
CCH60348      956 LNde---alPEYFVNMKTPFVAQGMKKIDDEIKVSYL-PHRRRRNEPLNTVDHHSEERESTQELLRKds-------eLPD 1024
Q7QKB2         82 KGgaggsslADIKLHRTGCARTEGYYKIDPREKAKYK-YHHLKGTVAANHLT-------------------------NLE 135  Anopheles gam...
6_pfamImport   75 VA-------ADPHAHKTGCARSEGYYKVNDSTKLI---QRRLMYRQADNTPQPRSKSKYSNE---------------SSS 129 
XP_007255047 1416 RE-------DGMRDHVTGCARSEGYYKIDKKDKLKYLiSSRPQFDEPDKDTQ-------------------------GKS 1463
XP_012809767 1508 RQ-------DGLREHQTGCARSEGYYAISKKDKDKYL-----KVLLVAAEEQ---------------------------E 1548
XP_005469029 1978 TD-------GQLREHVTGCARSEGYYAISRKEKDVYL-----DLDLPEQVIR--------------------------EV 2019
XP_008113606 1700 KS-------SDLREHQTGCARSEGYYHISKKEKDKYL-DVCPATVQQLDAPD---------------------------- 1743
XP_026690140 1674 RQark-ddiSDIKPHKTGCARSEGFYKVNDNTKL---------IQRKLMYRQADNTPQPKGRSKY------------ANE 1731 vase tunicate
XP_003668713  914 SESVSIQEISSSRDNRASNRRFQQNIEAQRAAIGAESDLLSLNQ 957 
XP_003687088  839 FMDNNNTDVSSSRVNRAMNRRFQQDIEAQKAVIGSESELLTLNQ 882 
CCH60348     1025 VPENTTPDISSSRINRAINRRFQQDIDAQRAAIGTESELLSLNQ 1068
Q7QKB2        136 LAKAVAKMQGISREARSNQRRLLNAFGA-----STESELLKFNQ 174  Anopheles gambiae str. PEST
6_pfamImport  130 TSVVANE---KSRETRHMMRRIASEFG------SDASDLLKYNQ 164 
XP_007255047 1464 IPAQPHASTRAGSERRSEQRRLLSSF-------SCDSDLLKFNQ 1500
XP_012809767 1549 ADTQGTN--RVLSERRSEQRRLLSAMGSTA---LLDSDLLKLNQ 1587
XP_005469029 2020 ENVDTSGANRVLSERRSEQRRLLTVIGTTA---VMDSDLLKLNQ 2060
XP_008113606 1744 ----TQGTNRILSERRSEQRRLLSAIGSFA---ILDSDLLKLNQ 1780
XP_026690140 1732 SASTSGVATEKSRETRHMMRRIASEFG------SDASDLLKYNQ 1769 vase tunicate
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