6S7T


Conserved Protein Domain Family
Malectin

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pfam11721: Malectin 
Di-glucose binding within endoplasmic reticulum
Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.
Statistics
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PSSM-Id: 403043
View PSSM: pfam11721
Aligned: 33 rows
Threshold Bit Score: 112.843
Threshold Setting Gi: 88784057
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6S7T_I         48 VIWAVNAGGEAH----VDVHGIHFRKDPLegRVGRASdy---gmKL-----------PILR-S----NPEDQILYQTERY 104 
Q7UIV5          6 LCLCIILIATPAirgqDIPLNVAEQPDT-----------------Qdksq---ltglDTDK-EldstATLDEFLVNSEHW 64   Pirellula sp.
Q231X5        114 KILAINCGENKFy--kDTSSKILYKPDTF--RDGGQVarre-dvrF-----------Q-QR-KtifdEIYDWNIHRTYVY 175  Tetrahymena t...
A0CEJ8          2 KYRSFN--------------GINYKNDQF--FQGSSEfvdy-ydeQ-----------Q----SvkvrKTVDQELYMTQRL 49   Paramecium te...
A0DJ13        493 VIHAIDCGSYLEt---RTSAGIKYKSDHH--HIGTSEfvdy-yesV-----------E----NrkirFTDDQSLYITQRQ 551  Paramecium te...
A0DRE8         13 HLLALSIRGQFN---------TQHLKDHH--YIGQSEivdy-yerA-----------Q----RrkikFTDDQSLYLTQRQ 65   Paramecium te...
wustl:BV2624 1081 YLYRLNCGGDTY----TDTYGQVWAQDNS--RYSHSWaesfihpSDsvqllspyqasQRTT-NdpihGTRDWELFQTFRF 1153 Bacteroides v...
Q01RD0        183 VPHPIRILAGSStdksVDRFGVEWAGDRY--FAGGEQ--------Nrwef----ggkEMGVpVrtirYAPDQLYFRSFRF 248  Candidatus So...
Q01NB6        205 DDLRIIVGAVNPf---MDRSGRTWGPDRF--FSGGSV--------------------LLHP-SerivRTLDPDLYRHLRT 258  Candidatus So...
Q021C7        211 NPLEVRILAGRQngdyTDRLGRIWQSDRY--FQGGSV--------------------FETH-DhaifGTREPRIYQGRRE 267  Candidatus So...
6S7T_I        105 NEETFGYEVPi----KEEGDYVLVLKFAEVYFAQ--------SQQKVFDVRLNGHVVVKDLDIFDRVGHST--AHDEIip 170 
Q7UIV5         65 GMRSFAQDVA-------DGDYLVNLYFAETFPRIt------gPGQRVFSFRVNG-IEFDEFDIWQKAGGSNrvYVESVp- 129  Pirellula sp.
Q231X5        176 DQKAFSYLLPl----KRSGEYSLIMIFAEINDIG--------AKKRVFNIIVEDEVVIPNFDIYTLAGGKQl-PHFEIie 242  Tetrahymena t...
A0CEJ8         50 GLN-FFYKLPlnkdsPETQNYILTLYFAELQYQE--------SNARIFEVFFGNKLVIENLDIYETVGMQT--AYSIDls 118  Paramecium te...
A0DJ13        552 GQS-FAYTIPignevPENQTYVLVLKFAELHYEE--------SNSRVFNILLGKKMILQNIDISQLVGPFT--AHTEYie 620  Paramecium te...
A0DRE8         66 GQS-FAYTIPigndiPENQTYVLVLKFAELFYEE--------SNSRIFNVMLGKMMILQNIDIFQLVGTFT--AHTEYie 134  Paramecium te...
wustl:BV2624 1154 GRHKLNFRFP-----VPDGEYRVELYFTEPWHGTgggvqtdcEGLRIFDVAVNDKVLLNDLDVWAEAGHDG--ACKKVvn 1226 Bacteroides v...
Q01RD0        249 G--NFSYRIP-----LPEGKYDLRLYFSEVIFLPtefg-dgvENRRIFDVLMNGQPLLSSFDIAADAGGANtaIIRAFsn 320  Candidatus So...
Q01NB6        259 G--DFRYAIP-----LKPGTYELHLHFAETGLADfisaessgEGQRVFHVSANGKRLLDFFDVVADANGVNtsDERVFrn 331  Candidatus So...
Q021C7        268 G--SFAYDIP-----LPAGVYELRLHFAETLYGEnnva-gggESSRVFNVSINGKEALHEFDVTSEVGPSTa-DVRAFkd 338  Candidatus So...
6S7T_I        171 -mSIRKGKLS-------VQgEVstftgklyiefvkGYYDnPKVCAL 208 
Q7UIV5        130 -vKINSGILW-------VT-FS-------------SEMDyPTIKAI 153  Pirellula sp.
Q231X5        243 -fSFQNRVLKnkskdnvIK-TYnatyqs-lnvtfeSIRGsAKLDAI 285  Tetrahymena thermophila SB210
A0CEJ8        119 fqKIGQQILYkg----eQI-NGalsknqeliirfkAIKSqAAIAGI 159  Paramecium tetraurelia
A0DJ13        621 -iIIDGGAVYyq---gkPC-IGalnnrnelvvgfsASQDqATVAAL 661  Paramecium tetraurelia
A0DRE8        135 -fIIDEGTVYyq---geIC-IGalnsrnelivgfsASQDqATIAAL 175  Paramecium tetraurelia
wustl:BV2624 1227 -aVVKGGVLK-------ID-FPe------------VKAGqALICGI 1251 Bacteroides vulgatus ATCC 8482
Q01RD0        321 vsPV-NGYLT-------LD-FR-------------PILSgAWLNAI 344  Candidatus Solibacter usitatus Ellin6076
Q01NB6        332 iaPAEDGFLH-------LA-FS-------------PVRGtAMLSAI 356  Candidatus Solibacter usitatus Ellin6076
Q021C7        339 isPEADGKLH-------LK-FE-------------PSSNpPLLCAI 363  Candidatus Solibacter usitatus Ellin6076
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