Conserved Protein Domain Family
Drc1-Sld2

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pfam11719: Drc1-Sld2 
DNA replication and checkpoint protein
Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication.
Statistics
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PSSM-Id: 371692
View PSSM: pfam11719
Aligned: 18 rows
Threshold Bit Score: 183.492
Threshold Setting Gi: 74634070
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7S438        14 SLQLRAELKQFEAEWAQKNdGKKPSREAIKQNPDIAQKYKQYNKLRDIL----SGKIPPPTKSNNQDPSQRKRKQPETSL 89  Neurospora cras...
O14216        10 ISSIKALLKKWEHEYVHTN-NCKPSKEDVKKQPEIALLYKQYYELKRESs--iTPKKAKTKVDFKFQTPTKQRAETEANE 86  Schizosaccharom...
Q6CK38        23 MDALKIEIKLWERAFEKEH-GRLPEKDDIKKDKEVKRKYKQYAQLKKDA-------TVKPSVEVNVEQTPVKSHVNNT-- 92  Kluyveromyces l...
Q6FME9         5 VQQVKLKIKRWEHAFIAEH-NRPPDKDDIRPLTEMKQLYKLYSVLKSKE----------------RKAEPIQKQ------ 61  [Candida] glabr...
XP_001643365   6 ISDLKIRLKTWEHEFIDKN-NRPPSKYDIQGLPEVKLMYKQYSALKKGK-----------------GAKIDKSENQLTPK 67  Vanderwaltozyma...
Q59UH5         3 IVEIKSKIKEWEYAFRKQH-NKLPSKADIKDDVEIHKLYSLYKSIKSGQ-----------------QQKPSKQETVNEPA 64  Candida albican...
XP_001527741  12 LEEIKHEIKSWEYKFKAEN-DRLPLKQDVNSIPEIKKLYALYKSYKTGK-------------PVKMEKREKSYKPEKTYK 77  Lodderomyces el...
XP_001383285   6 MEQLKTVIKKWEYSFREKN-DRLPSKSDIKANADIHKLYSKYRALKSGG-----------------HSSHSKRNYENEDI 67  Scheffersomyces...
Q6BXN9         7 ITQLKQAIKVWEHEFQRSN-NRIPSRSDIKVDPKVYELYKTYKVLKAKTnnvrNIQDKRTLESANIGIDINMSESQSDAE 85  Debaryomyces ha...
XP_001486665   4 LSDLRKEIKAWEHSFQKKH-GRVPLREDIKQNNVISSLYKQYRDLKKGP--------------AKTLKLPKKTRIDVQIG 68  Meyerozyma guil...
Q7S438        90 P--------SASTPSKRNRsaatpksqhysavheaitpdvarklfspavPSSIGPTPQKDGRVLGLFDLISHTPSKSTDE 161 Neurospora cras...
O14216        87 SpkaprndyLQVTPKTVD-------------------------------KSLLGPTPQLSRRVLNLLEDMSPIADSHVDQ 135 Schizosaccharom...
Q6CK38        93 -------------------------------------------------KAEFGPTPQMNGKLVSIFEMQVSAMKTHQSD 123 Kluyveromyces l...
Q6FME9        62 -----------QTPRKDS-------------------------------NMVLGPTPQIYGKAVSIFEMKVSPLKVEETP 99  [Candida] glabr...
XP_001643365  68 TlnnhkaldKFKSPIRSDSi-----------------------------KIELGPTPQIYGKTMSIFDMRISPVK-VPEQ 117 Vanderwaltozyma...
Q59UH5        65 S--------VQSSPVKRNDys---------------------------pRGELGPTPQANGRVLSIFDLKMTPPDSSPLK 109 Candida albican...
XP_001527741  78 Sd-------TYSSPLVSKNrsettd------------------vvpptpKGELGPTPQANGRVLSIFDFSLTPPESSPLK 132 Lodderomyces el...
XP_001383285  68 E--------SDLIPT----------------------------------VRELGPTPQANGKVLSIFDMRMTPPESSPLK 105 Scheffersomyces...
Q6BXN9        86 DveefnnenSDSSNNKLKNq-----------------------------DTELGPTPQANGKVLSILDIRLTPPDSSPLK 136 Debaryomyces ha...
XP_001486665  69 DsdedgsgtDMENTTSVAVg------------------------------IQLGPTPQANGKILSLFDTRMTPPESSPLK 118 Meyerozyma guil...
Q7S438       162 TK------------PRASGFTA--TPSNRRhALDLENDkddddhdekdgkefitpsiprhrnldRTPSSGRNRNLLDSFL 227 Neurospora cras...
O14216       136 ISdik------hntSEISSTMIptTPSKN-----------------------------------PEPVAQHTPTVLETPS 174 Schizosaccharom...
Q6CK38       124 QE-------------DIVGSPVrsNDLVRR-QLNFSITp------------------------nSSPMKQVPNLSANIVV 165 Kluyveromyces l...
Q6FME9       100 TTev---------eEDIESEIEs-SVNRRN-SDEASANe------------------------eKLGIHSVKKRLFESPK 144 [Candida] glabr...
XP_001643365 118 NIef---------nTPKNPSPAs-TISQSN-SSII-----------------------------SESTDVKRKLTFDVHF 157 Vanderwaltozyma...
Q59UH5       110 HKsd---------kASPSAFAM--PPPQSP-VKNII----------------------------ETPTKSKNKSFVTPIK 149 Candida albican...
XP_001527741 133 QKse---------kSAHNGTIKtdQFSQSS-GLDLL----------------------------VTPTKANKFSPFASTQ 174 Lodderomyces el...
XP_001383285 106 SRq-----------TSANPFTEfkTPTKVRvKHELRNT--------------------------PTRTDRGKESIFNKLK 148 Scheffersomyces...
Q6BXN9       137 NKvgsrstdtysnqKDEAPEDTfkTPTKTR-VNRINLS--------------------------ELTPTNNRGPRNKSLM 189 Debaryomyces ha...
XP_001486665 119 SKqtl------qvkEEVSDDKIfkTPTKKR-IVDI-----------------------------NAQLQAAAHQTSLSII 162 Meyerozyma guil...
Q7S438       228 GVRAtktstplnkntgnspsknNLTKTPSGERSVSKL------QFATPAFLRRTSa------------------------ 277 Neurospora cras...
O14216       175 SYRLq--------------------------------------VYTSPNLLRVNA------------------------- 191 Schizosaccharom...
Q6CK38       166 SRPK--------------------YGPNSPMRIGDIGl----qLSETPKTLGRTL------------------------- 196 Kluyveromyces l...
Q6FME9       145 KTentthl---------avpqvTRYGPNSPLKLAQTVs-----IRQHLLTPKKKK------------------------- 185 [Candida] glabr...
XP_001643365 158 TPVSsplkndeg---ikkpianGKYGPNSPLMIDRKDin--ftIRSTP--LKPIS------------------------- 205 Vanderwaltozyma...
Q59UH5       150 GRKI---------------------------------------VFETPSYLNKHRqn----------------------- 167 Candida albican...
XP_001527741 175 RKNS------------------NLESEATPLGAARKLnfaavmDVQTPNYMKQKTqt----------------------- 213 Lodderomyces el...
XP_001383285 149 NLSTen------------------------------------nHLETPKKKETQL------------------------- 167 Scheffersomyces...
Q6BXN9       190 QKLEqassak-------ntrieMHTPERNKVSLLQNM--------ETPQYLAKVNnkfnfdmdddsndkdnvvaedlhtn 254 Debaryomyces ha...
XP_001486665 163 KSSP------------------NVLPVPSP-------------VRQTPRYMSRNMfm----------------------- 188 Meyerozyma guil...
Q7S438       278 ----------------PLPPVDENGE----------WLDIEPL-KLPRKPFSiakgKGLSSVVA-SLRKMEEEK---LD- 325 Neurospora cras...
O14216       192 ----------------------------------------------PCR-------KSLSEMLR-ELKDIEDDY---GS- 213 Schizosaccharom...
Q6CK38       197 ---------------------DLKSS----------PFSPSPLiKRPVKTLSql-aKEHAIIKD-EFESNPEDF------ 237 Kluyveromyces l...
Q6FME9       186 --------------------AEPKSL-----------YTPSPLlKRNSSKTLyelaHEHLQYVE-EIKELDQQFk----- 228 [Candida] glabr...
XP_001643365 206 --------------------LATTSA-----------FSPSPLiKRPLTKSLvelaKEHEAIVE-EFSQIQEEDeneDEg 253 Vanderwaltozyma...
Q59UH5       168 ---------------pQTPDSHNNNNnnnnntvinfSVSPSPF--KTQRSIG----KRLTEVYNtSLKEAEDLKsfnLE- 225 Candida albican...
XP_001527741 214 ---------------pTFSRIMPLPDf---------LVSPSPL--KSQRMM-----RKLTEVYKtSLESIDADP------ 256 Lodderomyces el...
XP_001383285 168 ----------------VTPTRNPVIDf---------SVSPSPL--KSHRFFT----KKLTDVFH-EIKAMENS------- 208 Scheffersomyces...
Q6BXN9       255 ssmkiissirsniidpITPTKSPAPLk--------fQVSPSPL--KPHRLFSfgnnRKLSDIFN-DYKNIKEDP------ 317 Debaryomyces ha...
XP_001486665 189 --------------atEYGPVTPSKPtq------gfEVSPSPL--KPQRLFNyg-tKRLADIFN-EVQSIKENI---VVp 241 Meyerozyma guil...
Q7S438       326 -EELDMLRE-MEA-MEQGGMGPpppkqtvastsedtekkkqvtdpagaevvpeeensfEEDEAalieveasflespsskr 402 Neurospora cras...
O14216       214 -NEEKILQE-FESfSSSSSESL------------------------------------VDRDI----------------- 238 Schizosaccharom...
Q6CK38       238 -SEFTAIRTlMEKlMQEEHMDIi-----------------------------------EEGDEgt--------------- 266 Kluyveromyces l...
Q6FME9       229 -SEIVPIRH-----GNGQDIGD------------------------------------ESDEV----------------- 249 [Candida] glabr...
XP_001643365 254 nDEMITSNE-MVNvFSQEALDE---------------------------------------------------------- 274 Vanderwaltozyma...
Q59UH5       226 -EEFQSHEE-QESeETETTTN-------------------------------------NDRKI----------------- 249 Candida albican...
XP_001527741 257 -ELASEFNT-AEMeINDGMIEKe----------------------------------eNGGEA----------------- 283 Lodderomyces el...
XP_001383285 209 -DELEIEENeEEDiHEDIDNDN------------------------------------DGNQK----------------- 234 Scheffersomyces...
Q6BXN9       318 ----DLINS-IENeEEAAELDD------------------------------------DDDTIe---------------- 340 Debaryomyces ha...
XP_001486665 242 eDLNDPVSE-EEVdGEKSSEGP---------------------------------------------------------- 262 Meyerozyma guil...
Q7S438       403 kkerrpvllsgfddenfydSQDEEDlskegldrngqplRVFKKKGQKRTTRKVNMRPTRtkrpsapIAEEEDDGEEEHND 482 Neurospora cras...
O14216       239 --------------------------------------SQPMKKKIKRQNRLVKLPPSM-------------NLSKSHLE 267 Schizosaccharom...
Q6CK38       267 -----------------vgNETESN-------------YVRKVKTIKKRTK-AKMRPAAln---ekSTNIPDKNVHEQLA 312 Kluyveromyces l...
Q6FME9       250 ---------------------------------------PEKKKRRTGVLRRLQFDed-------eNDRTIKKDLHKELL 283 [Candida] glabr...
XP_001643365 275 --------------------------------------HINKKIKRRRVIRRFAEESDI--------SKSVTIDIHKEIY 308 Vanderwaltozyma...
Q59UH5       250 --------------------------------------APRSKRTQKRSTRRVKMAPRPvn----sKPSLENVNLQDHIT 287 Candida albican...
XP_001527741 284 -------------------ISVENR-------------GMRKQKTQKRLTRRVKMAPRLen----eGQTLDTVNIQDRIQ 327 Lodderomyces el...
XP_001383285 235 --------------------------------------PRRKKFTMKRTTRRWKMKPTIqan--vdGDSIAKKNIHDEIK 274 Scheffersomyces...
Q6BXN9       341 ------------------kDTATNG-------------PKRKRITQKRTTRRWKIKPNTee---tkEDKLKNANIHDEVK 386 Debaryomyces ha...
XP_001486665 263 --------------------------------------KPKKAKTQKRTTRRWKIKPRPea---enETSLEKKDIHEAIQ 301 Meyerozyma guil...
Q7S438       483 VIPETQFDatknldgddhHTLDSLsSGG--SGSEFDDGSEGEDEEAETSTTKAAKAaAKkkapSAKEKTKKDATTetkkk 560 Neurospora cras...
O14216       268 GLPEI--------------------DEDaeNGIDDNEDTTASKDSSPFLDLQS----------ERQNKKIMRNGLvigk- 316 Schizosaccharom...
Q6CK38       313 KLKER-------------EYNKML------GKEVEESESDSEQQSNPPVKK------------KQRKSKYNLVSN----- 356 Kluyveromyces l...
Q6FME9       284 KLKSR-------------KVKEFL---GkeDNEPSEEEEEEQQKSEPLPVK------------KKKPKKYNLVSN----- 330 [Candida] glabr...
XP_001643365 309 RLKRK-------------QLNEFL-GDNeiDEEDENNFTDSISDEDNNKTEEAKAPvKR----KTRGNKLRLVSN----- 365 Vanderwaltozyma...
Q59UH5       288 KLEEGERK----------QLVAYM-----------DSDEDDENRDGEVGIASVFE--------SPTKKTRMPVSN----- 333 Candida albican...
XP_001527741 328 LMEEQERT----------SLMAYMnSESedDDDDDDDDDDSDNEKEGEGKRNRGNNgNGvq-qSPIKRTRKPVTA----- 391 Lodderomyces el...
XP_001383285 275 KLDDKQKT----------DLEAYM-------------ASDDESEEEPIIVKKAk--------pQSGAKKIKPMSN----- 318 Scheffersomyces...
Q6BXN9       387 KLDDEARK----------NLVDYM-EVNnmHEEDETTSEEEYVHQDPNH--------------KDMKGKVKPVRM----- 436 Debaryomyces ha...
XP_001486665 302 DIDEKRQR----------NHERYL------------NSEDEESDAEPEKIIP-----------QALGKKIKPVSM----- 343 Meyerozyma guil...
Q7S438       561 kgtkeggdeepakkprmvkatanaNFKRLKLKNNgaKGGPahNSRFrRRR 610 Neurospora crassa OR74A
O14216       317 --------------------qvsqNYSSYKLKKR----------KFrRHR 336 Schizosaccharomyces pombe 972h-
Q6CK38       357 ------------------------NFKRLNLPTKagRNRA---SKWrGRR 379 Kluyveromyces lactis NRRL Y-1140
Q6FME9       331 ------------------------NFRRLKLPKK--NRNP----RFgRRR 350 [Candida] glabrata CBS 138
XP_001643365 366 ------------------------NFRRLKLPRK---NRF--KGRWgNRR 386 Vanderwaltozyma polyspora DSM 70294
Q59UH5       334 ------------------------NFKRLKINDP--RSRRf-KQRM--RR 354 Candida albicans SC5314
XP_001527741 392 ------------------------NYKRLKINDP--RSRKf-KQRM-RRR 413 Lodderomyces elongisporus NRRL YB-4239
XP_001383285 319 ------------------------NYQRLKINDP--RSKAf-KRRM-SRR 340 Scheffersomyces stipitis CBS 6054
Q6BXN9       437 ------------------------NYQRLKINDP--RIKKf-KKRMqNRR 459 Debaryomyces hansenii CBS767
XP_001486665 344 ------------------------NYQRLKINDP--RAKAf-KRRM--RR 364 Meyerozyma guilliermondii ATCC 6260
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