6V4X


Conserved Protein Domain Family
CPSF73-100_C

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pfam11718: CPSF73-100_C (This model is not part of the current CDD release)
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known.
Statistics
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PSSM-Id: 519847
Aligned: 137 rows
Threshold Bit Score: 107.211
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6V4X_H       479 QRVSGI-LVK--RNFNYHILSPCDLSNYTDLAMSTVKQTQAIPY--T-GPFNLLC-----YQLQKLTGDVE--------- 538 human
XP_001564581 491 EFVSGVmLVS--GQHQYSIVHPDDVPVFTDLSVNRVQQAMVLPLprHrSPLEVLQvlqryFAQSKLFEDVAprqsteqea 568
XP_006878663 488 EHVNGL-LVK--KGFTYQIIAPEDLHIFTQLSTGNIAQRISVPY--E-GAFSVIR-----HRLKQIYESVEp-------- 548
XP_006357977 489 EIVSGL-LVK--KGFTYQIMAPDDLHVFSQLSTANVTQRITIPY--S-GAFAVIQ-----HRLKQIYESVEs-------- 549
XP_003633408 488 ETVSGL-LVK--KGFTYQIMAPDDLHVFSQLSTANVTQRITIPY--T-GAFGVIK-----HRLKQIYESVEs-------- 548
XP_002508805 494 DRVSGL-LVQ--KDFGHMIIAPEDLHEYTSLKTAKLTQRQKVPT--T-QKLGELR-----FALEALFEGIH--------- 553
XP_002948028 493 GVVRGV-LVRqaGGFGQQLLHPDDLPRYTKLLKGRVTQRQAISV--D-VPFSVIR-----LALEVMFEGVEgagtv---- 559
XP_020432373 379 KKIAGL-LVT--KDFTHHIIAPSDLHNYTNLKINTIKQKQTVPF--A-QKYLLLS-----STLEQLYDEME--------- 438
XP_004352396 494 TSVQGL-LVI--KDFTHTIMAPGDLQNFTNLKTNIIKQKMTIPF--A-QNYLLLK-----STIQQLYDDVKeqe------ 556
Q86A79       501 DIIQGI-LVT--KDFTHHILSASDIHNYTNLKTNIIKQKLTLPF--A-QTYHILI-----STLEQIYEQIIest------ 563 Dictyostelium d...
6V4X_H       539 ---------ELEIQEK-PALKVF--KNITVIQEP-GMV--------VLEWLANPSNDMYADTVTTVILEVQSNPKIRK-- 595 human
XP_001564581 569 teaqqaaaeRGETRDLdTTLLFVs-KDVTVDVHk-SSQaqt---tlTITWYSSHYNDLLADVTCIALAKLAEEPHEAE-- 641
XP_006878663 549 ---------LGDPTESpTALLVH--DRVTVKQENtKCV--------SIQWSTDPISDMVSDSVVTVILNINRGIARVG-- 607
XP_006357977 550 ---------STDEESGvPTLRVH--ERVTVKQESeNHL--------SVHWTADPICDMVSDSVVALVLNASREMPKVSi- 609
XP_003633408 549 ---------LPDEESEvPAFRVH--ERVTVKHESeKHI--------SLHWTSDPISDMVSDSIVALVLNISREIPKVVv- 608
XP_002508805 554 -----------TGSPEpPGLSVNg-GQLTILKRPaDKKwga--ehaLLQWDADPINDMIADAVLSVILQLEEEPEHLTra 619
XP_002948028 560 ----svtsvPGAAGKGkEVLAVMvgDTVEVRYIp-ADDttgmvahvVLEWEGGRHGDMVADAVIAVVLQAVGEPVGASna 634
XP_020432373 439 ---------ESKTKDDkPTIKIY--GSILITYNVgSHV--------TIEWDSNPVTDMVADSIVALIMQIESNPFSLRvk 499
XP_004352396 557 -------siNNNNNNNnPILKIY--NSIIITLFApTHV--------IIEWESNPVNDMISDSVIALISQIETNPFSLRvg 619
Q86A79       564 -------esTGGGGNEkPTITIY--NEIKLIYNIgVSI--------ILEWNSNTVNDMICDSIIALISQIELNPLSIKvr 626 Dictyostelium d...
6V4X_H       596 -----------------------------------------------GAVQKVSKKLEMHVYSKRLEIM--LQDIF---- 622 human
XP_001564581 642 -----------------------------------------------GEDVLVPADVSGQDRIFRVKCFhsMISQFyssv 674
XP_006878663 608 -----------------------------------------------VMGEGVTEEEMERTAEKVVLAL--LNSLF---- 634
XP_006357977 610 -----------------------------------------------DSETSINEEEDAKKTEKIVHAL--LVSMF---- 636
XP_003633408 609 -----------------------------------------------ESEAIKTEEENGKKAEKVIHAL--LVSLF---- 635
XP_002508805 620 ea------------------------------------------ahkDAMKNKDKAGVQAARLRIVAAM--LGVQF---- 651
XP_002948028 635 es------------------------------------------amnRARAAGDETAAAAAELQLIAAL--LRSQY---- 666
XP_020432373 500 sskenngdiiltdeqsss----------sgiplvkmekeneqdeedlTIMTKSRKKSQQLTLRTEIMTM--LSKQF---- 563
XP_004352396 620 emnnnnnnnnnngdtepinngngqtikvkkeksddqeeeeedeeqdvMIMTKSRKQSQKIEMITEVKSL--LEHQF---- 693
Q86A79       627 npnfnnidekeeitkddiek-----ekekekeqqdgddddddeiqikVVSRKSRKLSNKLNTITEVKLL--LEQQY---- 695 Dictyostelium d...
6V4X_H       623 ------GEDC--VS----VKD--DSILS-VTV-DGKTANLNLETRTVEC------EegsedDESLRE---------MVEL 671 human
XP_001564581 675 ktnlssGSCS-------------------VTLaDGQVANI------VDCievyleS-----STGKKDvdydapevqKLKQ 724
XP_006878663 635 ------GDVKrvAGeegkM------V---VSV-DGVVATVDSKSGVVEC------E-----NEGLKQ---------RLRT 678
XP_006357977 637 ------GNVK--FGddgkL------I---INF-DGILAHLDKQTGDVEC------E-----NEALKE---------RVKT 678
XP_003633408 636 ------GDVK--LGengnL------V---ISV-DGNVAHLDKQSGNVES------E-----NEGLKE---------RVRV 677
XP_002508805 652 ------GEPRa-IDeenqVV-----E---LRV-ENADVAVRYGNRDVDC------A-----DAAVKA---------RVET 695
XP_002948028 667 ------GPAV--VDeaggSI-----S---LSV-DGVSVLVDYRAGKVIC------G-----EVGLRA---------RIEK 709
XP_020432373 564 ------SELK---------PDqdDPLLMhLHIdDDKSASIHLETLKVHS------N-----TPELKT---------QIEK 608
XP_004352396 694 ------GPMQ---------PDsdNPLILlFNL-DDKNASIHLEDLTVEC------A-----DSELKQ---------YLEN 737
Q86A79       696 ------GNFK---------VDenDPLILhFNL-DNQKAIIHLETLTVES------L-----DQILKQ---------KIEN 739 Dictyostelium d...
6V4X_H       672 AAQRLYEALTP 682 human
XP_001564581 725 ILKRIYLTLFP 735
XP_006878663 679 ALRRIKSAVKP 689
XP_006357977 679 AYWRIRSAVKP 689
XP_003633408 678 AFQRIQNAVKP 688
XP_002508805 696 ALGRIDMAIAD 706
XP_002948028 710 SLDRLATAIRP 720
XP_020432373 609 AIRRISLAVHP 619
XP_004352396 738 SINRIKLAVHP 748
Q86A79       740 SIKRIILSVSP 750 Dictyostelium discoideum
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