1WGS,2BUD,2LRQ


Conserved Protein Domain Family
Tudor-knot

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pfam11717: Tudor-knot 
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RNA binding activity-knot of a chromodomain
This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding.
Statistics
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PSSM-Id: 403041
View PSSM: pfam11717
Aligned: 42 rows
Threshold Bit Score: 37.1867
Threshold Setting Gi: 122157342
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WGS_A     13 VEIGE----TYLCRRp--------DSTWHSAEVIQSRVn---dQEGR----------EEFYVHYVGFNRRLDEWVDKNRL 67  house mouse
KIS71300   22 IGSAC----QVYDSK---------TGESYPATVLSRRSg----SSSTppsagadtdnVQYYIHRHDQDKRMDGWVDCSSI 84  Ustilago maydis 521
Q4UHT8     47 REIFSqqfpTAYPMEyelwgkdlmHNTWRRCTVVHARPv----DPNKeipll-kpneYDYYIHWLGLDRRLDCWLTIENI 121 Theileria annulata
ABQ51913   38 lDIGE----HYLVRRs--------DESWHPAEIIQSRYs---tAESC----------YEYYVHYVGYDRRLDEWVSRHRV 92  domestic silkworm
Q29JC6    216 IVVNEdsekVYYIRRe--------DGTVHAGRVLQSRI-----TANVlm-------pNEYYVHYVGLNRRLDEWVGRHRI 275 Drosophila pseudoo...
2BUD_A     11 IDISEnpdkIYFIRRe--------DGTVHRGQVLQSRTte--nAAAP----------DEYYVHYVGLNRRLDGWVGRHRI 70  fruit fly
Q171E0     52 LVIGA----EYLVQRq--------DGSWHPAQLIQSRQnpcdpKQ------------QEYYIHYEGLNRRLDQWVSRDRI 107 yellow fever mosquito
2LRQ_A     13 FVDGE----RVLCFH---------GPLIYEAKVLKTKP-----DATP----------VEYYIHYAGWSKNWDEWVPENRV 64  fruit fly
Q4SLW2     11 FQEGE----RVLCFH---------GPLLYEAKCVKISI-----KDKQ----------IKYFIHYSGWNKNWDEWVPESRV 62  spotted green puff...
XP_321270   7 FTEGE----KVLCFH---------GPLLYEAKLLRCAMm----KEKQ----------VKYLVHYAGWNKNWDEWVPESRV 59  Anopheles gambiae ...
1WGS_A     68 AL 69  house mouse
KIS71300   85 RP 86  Ustilago maydis 521
Q4UHT8    122 RT 123 Theileria annulata
ABQ51913   93 ms 94  domestic silkworm
Q29JC6    276 SD 277 Drosophila pseudoobscura
2BUD_A     71 SD 72  fruit fly
Q171E0    108 SS 109 yellow fever mosquito
2LRQ_A     65 LK 66  fruit fly
Q4SLW2     63 LK 64  spotted green pufferfish
XP_321270  60 LK 61  Anopheles gambiae str. PEST
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