6LK8,4FHN


Conserved Protein Domain Family
Beta-prop_Nup120_160

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pfam11715: Beta-prop_Nup120_160 (This model is not part of the current CDD release)
Nucleoporin Nup120/160, beta-propeller domain
Nup120 is conserved from fungi to plants to humans, is homologous to Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. Nup120 is one of the proteins involved in creating the nucleoporin basket together with Nup98 and Nup153, which plays a role in mRNA export. This entry represents the beta-propeller domain for Nup120 and Nup160.
Statistics
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PSSM-Id: 519845
Aligned: 339 rows
Threshold Bit Score: 36.5316
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LK8_E          101 RFLHWt---SYADTLELVEISLD---INLVNNAVRLRiLNCSIlpG---GVHICET----PNn------IVVLILTNQTV 161  African cla...
28_pfamImport     1 TYIIWrinrSQENVVEIMQLNDN---KEFLKIGLQIV-FPDALfpS---TLLCKNE----TNfls--rgHFTLYAMTISG 67  
XP_019260078     56 AYFTWkicrSQPNVLEIMEFCGY---KEFPKTGLQIV-FPEALfpF---ALICKNE----MTfss--vrPYLLHAMTVSG 122 
1_pfamImport      1 FHLIWrlhkTQSNVLEIFKLSQE----FPLNSGLRLI-FCHPLspF---AFISTSP----TDs------HYLLYTLTVSG 62  
54_pfamImport     1 TYLIWrihkTLPHSLELLQLSSSstnAGFPSVGLRFT-FPDALspF---ASVCVSQ----NQ--------ITLYVLTISG 64  
25_pfamImport     1 TYVIWrihkSLPSVLELLELCAD---KEFPRIGLRIA-FPDSLsaS---AFVCRNE----VDvns-rnhPYVLYALTVSG 68  
21_pfamImport     1 TYLIWkihkNLPHALELLELSAS---KDFSKVGLRIT-FPDALspL---LLLCKNEidvgSRs-----hPYLLYALTVSG 68  
XP_040370156     71 THLIWrihkHLPHSLELLELSAN---KEFPKLGLRIT-FPQALssS---VF-LCKN----EIdvgsrshPYLLYALTVAG 138 
53_pfamImport     1 AYFIWrihnNLPNVLEVLELCPQ---KEFPERGLRLV-FPESLftF---SFICRDE----VRnva--grRYMLYALTMSG 67  
103_pfamImport    1 SYLIWrlhkDSPNILEVVEVIAS---KEFPQTGLHLV-FRDALcpSaflCKNVINS----GSg-----nAYLLYVLTVSG 67  
6LK8_E          162 HRLILPHP--SRMYRseiisdshiqsiFTDigKTNFHDPSNTY-VIpAIPGRApntTASTAwlssdgeALFALPSISGGI 238  African cla...
28_pfamImport    68 IAFLIKLKd-ISTYVps---------sVLSsnEVLECNTQMHC--H-HGAITM---ATSTS-------GCIVVGRNDGSV 124 
XP_019260078    123 VAYLIRLEn-ISNYVss--------srLQSd-DFVEFNTLTHP--H-QGATTA---VAGIA-------ELMVVGRSDGSV 179 
1_pfamImport     63 IAYFIKISkdl--------------asIVSrdELIELDVRDYS-NS-NEPITC---IAAKP-------GCLLLGRNDGSV 116 
54_pfamImport    65 LAYLLKLTnnISTYNvsn-------stFPPd-HLFEFDIRRTH-SN-HGPITS---VAATA-------GCLVAGFNDGSV 124 
25_pfamImport    69 IAYLLRIR--NVSANks--------ssILPseDVIRVFDMCSY-----GPITSv--AAVPS-------GCLIVGRSDGSV 124 
21_pfamImport    69 VAYLLRLGp-ISTYVsh---------sGFRldELVEFNVNAYG------PVTSa--AAMPS-------GCLVLGRGDGSL 123 
XP_040370156    139 VAYLLRLGtv----------------sSYAsnSVIREFSLHPY-----GPITSa--AATPT-------GCLVVGRNDGSL 188 
53_pfamImport    68 AAYLFKLGd-ISTYVsg---------sVLSqsEY----VEVDVqTD-SKVI-A---VAATF-------GCLLLGRQDGSV 121 
103_pfamImport   68 VAYLLSLR--S-PFSyis-------gsSFPqrEYVEFNVEPPT------QITA---VTAAA-------GCLVTGRQDGVV 121 
6LK8_E          239 LVIKMp----pHDMEGLVTIAELK--Q--SSVMQRLLTGWMPSSirg-dqgPA-HLPVSLavhtldHDSYLFALCQDHKL 308  African cla...
28_pfamImport   125 CCFQL--------GTIEPS---AP--G--FVFELRDDVGFGRLWgim-srsRTiAAVQDLviselcQKKLLFVLHSDGTL 188 
XP_019260078    180 GCFQL-------------GILDHRapG--FVQELRDDGGLGRLWgvl-srgRSiAAVQDLvisefhQKKLLFVLHSDGSL 243 
1_pfamImport    117 TCFRLgllhqtAPGFVYELRDD-------SGISLGRLWGfms-------rgRAvGAVQDLiitemhGKEIVFVLHGDGIL 182 
54_pfamImport   125 CCFQLgtildhTAP------------G--FVHELRDDPGMGRLWgfm-srgRVvGPVQDLviyevhGKQFLFVLHSDGIL 189 
25_pfamImport   125 GCFQLgml-dpSAPASMHELRDDS--G--F-GRLWGFVSr----------gRTvEAVQDLvvakvcGKQLLFVLHSDGTL 188 
21_pfamImport   124 ACLQL--------GSLDP---SAP--G--FVRELRDDSGIGRLWgfm-srgRMvGAVQDLvisvihGKPLVFVLHSDGML 187 
XP_040370156    189 ACFQL------------TLESTAP--G--FLQELRDDPGIGSLWgfm-srgRMvGAVQDLaismvhGKPLIFVIHTDGVL 251 
53_pfamImport   122 TCYQLg---------ILE--QSTP--G--FTFELRDDVGIGRLWslv-srgRSiCSVKDLtvsqlvSRKLVFVLHSDGTL 185 
103_pfamImport  122 SCFQF-------------GILDPS--SpgFATELRDDVGIGRLWnlmsrqkAI-GAVQDMvisdvcKRKCLFVIHADGLL 185 
6LK8_E          309 RMWSYKDQMCLMV--ADML------------------------------------EYVPVSKDirqtAGTGHKLRLAFSe 350  African cla...
28_pfamImport   189 RVWCLSNRSKVLT--HTMT--------------------------------------GAPCARlwvgMDDSDTNIIPLA- 227 
XP_019260078    244 RVWDLSNHSRIFS--HSLSvs---------------------------------pSAGSSSVRiwvgNDHNNPDAIPLAv 288 
1_pfamImport    183 RAWDLSSHTRILS--HSTA------------------------------------VEGTTSTRlwlgESNNNSKIVPLA- 223 
54_pfamImport   190 RIWDSTSHSRIFS--HSMSipelagnfnyflfsflnfqfvqsftrkqklivsngdIQGATFKRlwvgQVENDSSIIPLA- 266 
25_pfamImport   189 RVWDLSCRIKVFS--HNMNhpml----------------------------agkfLHRAALVRlwagEADQDSSVVSLA- 237 
21_pfamImport   188 RVWDLSCHSRLFS--NNMNsp---------------------------------tLAGATLVRlwigQVDNDSTLIPLA- 231 
XP_040370156    252 RVWDISFHSRLFShkMNSLt-----------------------------------MAGAALVRlwvgQADNDSSIIPLA- 295 
53_pfamImport   186 RVWDLLNHSKVLN--HVVV------------------------------------VPEVTASRiwvgDPNYDTGIIPLA- 226 
103_pfamImport  186 RVWDLVSHNKVVS--YNTSsn---------------------------------eLEGTKPSRlwvsEANYDANLISLAi 230 
6LK8_E          351 -----TLGILYLGVYL---HTPKQGQFCVFQlmcaesNrYSLdHISSIFTNQE-----------------TLIDFTFTLT 405  African cla...
28_pfamImport   228 -------------VLQ---KHHSEVGMETLSlss-lyFsV-G-DKIDLSLESStqsip--------lekgNLVDLKFTKN 280 
XP_019260078    289 lrkddSEVGTAMISLYs-lYFSTGDRFNLLL---------------D--PSTKsisle--------epqgELIDVKLTPN 342 
1_pfamImport    224 -------------ILYkrtLEVGMEMIYIYSlcy-gtG--DR-MILSVDSSVKsfpv----------deggCIDVKLTSD 276 
54_pfamImport   267 -------------ILYgetSEVSLEMIYVYGl-----H--------CSFGDRTilllepsv-qnilleegGCIDVKLTSD 319 
25_pfamImport   238 ----------ILSRRS---TDVSSEIVYLYS--------------LHCSLGDRivllldpsistipledgACIDVKVASD 290 
21_pfamImport   232 ----------ILYRHT---SDISSETIYAYSlrc-nfG--DR-FILMLEPSAInipl----------eevgCVDVKLTSD 284 
XP_040370156    296 -------------ILYrhdSEMSSETIYVYSlh---cNvGDR-IVLSMDPSEQiipi----------eedgWIDVKLISN 348 
53_pfamImport   227 -------------VLYg--SAIDSDSMIALHyihftaG-EKI-TLSPNVSIQTipld-----------qgiLIDLKLTSH 278 
103_pfamImport  231 ----lHDG-----VPL---SDIEMVAVYHFGlgp-gdK-------ILLSP-Qpssqsi-------hldegKLIDLKFESD 282 
6LK8_E          406 smDIWALWLDDDN-Q-------------TVVKHINFEENQa------------GQWNPVf---VNPLPEDDLAISDEQep 456  African cla...
28_pfamImport   281 --QLWMLREDGLVmQnli-------ngnI-------EEGLaqcyslqeafvadQLFQHCekssDDLLWLSGAVLSSSKde 344 
XP_019260078    343 --KLWILSENGLVmKelfc------qnrKeelaycys--------lqntfvaeQLFQGSenssDDLLWLCHTVLSSSKdq 406 
1_pfamImport    277 --KIWILKDNGLGyHhlfhrsstteeahCYALQEEFIAd--------------QLFQSLehtsDDLISIARSIFSSGKdh 340 
54_pfamImport   320 --KIWILKDNGLVfHn------------LLLTTVNVEEAqcyalq--eefvadQLFQSSehssDDLLWITHSIFSSGKdh 383 
25_pfamImport   291 --KIWVLKENGLVlQs------------LLHTNVNVPAEEtsyytlqeefvadQLFQSPeyfsDDLLLLTHSVFSSAKdq 356 
21_pfamImport   285 --KICILKNNGL--V-------------LHNLLTNVNTEDacsyalqedfvadQLFQSSehssDDLLLITHSVFSSSKeh 347 
XP_040370156    349 --KICILKNQGLVlH--------------KLLHTNVNMVDavcyalqedfvadQLFQSSehssDDLLLITHSIFSSSKdh 412 
53_pfamImport   279 --KLYILKEDGSMfYdllhs----dirvEHMNSYGLQEDFisdh------lfqDPHQPs----DDLIWNEASVFSSQKeq 342 
103_pfamImport  283 --KLWILKGDGSMlFd------------LSQTDFKMEHTVayglqe--dfvadQLFQSSehalDDLIWTDHSIFSSVKvq 346 
6LK8_E          457 qe-----ayleCLFAPGRFTIAAVQKAIQILRkgsG--RVLDLSWEELRKDVTLTVENEIqnaviDYDVSQEEFRQinIE 529  African cla...
28_pfamImport   345 iasfvsyiflrRLLLPGIHHNTILRATLQEYNkhfTdsEFDSLTINGLKNEILSLIEHEG-----GAESPVSIVHS---- 415 
XP_019260078    407 ispfvssvflrRLLLPGVYHRNVLRATLRDFSkhlTdsEFDSLTVDGLKNEILSVIQHEV-----GADSPISILQR---- 477 
1_pfamImport    341 ivpfvssiflrRLLHPGVCQNIVLRATFLDYRkhwTdnEFQSLTVDGLKKEILSLVEHES-----IAESPISIFQG---- 411 
54_pfamImport   384 ivpfvssiflrRLLCPGIHHNMSLRATLLDYNrhwSdsEFQSLTADGLKKEILSLIEHEG------STENSSVFYC---- 453 
25_pfamImport   357 sssvissiflrRLLHPGVYHNIVLRATFLDYNrhwSdsDFQSLTADGLKKEILSLIEHEG-----VSENLLSIYCS---- 427 
21_pfamImport   348 ivqvvssiflrRLLLPGVYHSIALRSTLLDYNrhwSdsDFQSLTADMLKKEILSVIEHEG-----VNDNSTSIFCC---- 418 
XP_040370156    413 ilpvvssiflrRLLLPGIHHNAALRTTLLDYNrhwTesDFHSLTADGLKKEILSLIEHEG-----LTGNSSSIFCC---- 483 
53_pfamImport   343 vpyiissiflsRLLQPGVHQSTALRATILDHRkhvTehEFLSLNVAGLKKELFSIIESEG-----ASANPISMFYY---- 413 
103_pfamImport  347 aaylvsslylrRLLQPGVYLTTALRATLLEHKkyiSdyEFRSLTMDGLKKEIFAIIEGE--------GAATNSTTT--VY 416 
6LK8_E          530 NWCKFYTCCLQYQETLSRPLALLVHPDTNMVCLLRKGFLSFLAPCSLVE 578  African clawed frog
28_pfamImport   416 -WKSFCTRYVHNWCQYNAARALLVDSSTGAVGLIRKNTISLCRSLNNVE 463 
XP_019260078    478 -WKTFCTCYFNNWCRTNVAYGLLIDSATQAVGVIRKNSVSMCRSLEDIE 525 
1_pfamImport    412 -WKNFCCRYFECWCKNNAPYCLIVQSTSGAVGLIRKHSVSLFRGLENAE 459 
54_pfamImport   454 -WKNFCMRYYHNWCKNNAPCGLFVDSSSGAIGLIRKNSFSLFRCMEDIE 501 
25_pfamImport   428 -WKNFCARYFHNWCKSNAPCGLLVESTAGSVGLIRKSSVSLFRCSEDIE 475 
21_pfamImport   419 -WKNFCSRYFQNWCKSNAPCGLLVDSSTGTFGLVRKNSVSFFRCLEDIE 466 
XP_040370156    484 -WKIFCARYFQNWCKSNAPCGLLVDSSTGTVGLIRKSSVSLFRSLEDIE 531 
53_pfamImport   414 -WKNFCAQFVYHWNETNRPYSLFVDSSTGSVGLIRKASISVFRNLEHFE 461 
103_pfamImport  417 YWRSFCTHFLRHWCQNSTPYGFFVDSSQNVVGLIRKNSVSLFRSLEGIE 465 
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