Conserved Protein Domain Family
Vma12

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pfam11712: Vma12 (This model is not part of the current CDD release)
Endoplasmic reticulum-based factor for assembly of V-ATPase
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterised member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localised to the endoplasmic reticulum.
Statistics
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PSSM-Id: 519844
Aligned: 86 rows
Threshold Bit Score: 60.6997
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001539928  76 SLLKGT--RVYVPPPPPKPDpTPE-----------------------------------------------------YLA 100
ELV12086      78 ELLEGS--EIYLPEVVKPPR-NPE-----------------------------------------------------LVA 101
6_pfamImport   1 ELLEDS--MLHLPEVVKPPR-NPV-----------------------------------------------------LVA 24 
Q19259        16 DLVAGSkeKI-----------TPEvsksckefykkdvvsykdlvniktklpdgipvfvffdrltlrredhtyhasveFRK 84  Caenorhabditis ...
XP_002433201 283 ELMKGS--DVILPKNEVVER-NPD-----------------------------------------------------LLK 306
XP_003437151 152 ALLAGC--RLKLPENPICKR-NPE-----------------------------------------------------LEA 175
ETN63645      98 SLLADC--WIVLPER------SEQdps-----------------------------------------------svcSEV 122
XP_002013492 149 ELIESS--DLVLPENEMKPR-NPD-----------------------------------------------------LEA 172
XP_003424813  80 QLLEGV--DIILPEPKVTPR-NPE-----------------------------------------------------LEA 103
EFN73800       6 ELFNDC--DVILPIPKESPR-NPE-----------------------------------------------------LEA 29 
XP_001539928 101 LKASLLAAEEARRYNALLNAasssspsriwglndppatniythpkhhhhhnndnnnninintindlDA-DDPLT------ 173
ELV12086     102 RLEKIKIQLANEEYKRITRNvtcqdp----------------------------------rhsgtlSDlGKQVFfpgvls 147
6_pfamImport  25 RLEKIKARLANEEYSRITRNvntqevsrggtla------------------------------------------dfgre 62 
Q19259        85 KTEELRIQQEQDSYKRLIRDvdpvqkygktdhm------------------------------------------enfgv 122 Caenorhabditis ...
XP_002433201 307 RIEKLKKEQEEREYKAMTQNvnldkkhfpeds---------------------------------------------vsy 341
XP_003437151 176 RCQRLRKEQEDREYHRMTKNvdsirkhmpeet---------------------------------------------isy 210
ETN63645     123 DCAQKVRKEKQVENQQMTRSsdtarkpmpgdt---------------------------------------------idf 157
XP_002013492 173 RCERLRAEQHNREYHKMTKNvdaglkhypedt---------------------------------------------iay 207
XP_003424813 104 RIKKLQAQQDARDYQAMTKGvdnfrkhipedt---------------------------------------------iaf 138
EFN73800      30 RIQKLKAQQNAREYQTMTKNidsmrkflpeds---------------------------------------------iay 64 
XP_001539928 174 --------PSVVLNILVSILFTGFATYWALSNFriptfftftssaapshpgtvsSQPARVFISMLVALLVGVAEVGIFAL 245
ELV12086     148 kvrsvkalVVTIFNFIVTVVAAFVCTYLGSQYVf-------------------tEMASRVLAALIVASVVGLAELYVMVR 208
6_pfamImport  63 avrsvkavVATVFNFLVTVVAAFACSYMGSQYLf-------------------tDTGARVIAAVIAASVVGLAELYVLVR 123
Q19259       123 emravnrqMISVINVVITVVGSFFFGFSGITYAyph---------------lnlDLPTRFIFGLVPATIVFFCDLYFVVK 187 Caenorhabditis ...
XP_002433201 342 qmnmmnrhLIAVGQLLVSVGAGFAFGFLGVELIvg-----------------nlNFGIRLLLGIACALIIAVAEFYFLAK 404
XP_003437151 211 qmkqinrhLIAVAQFLFSVAAGFAFGFIGIELLig-----------------qlDFGFRLLLGIIIALIIALAEIYFLAK 273
ETN63645     158 plkhlnrhLLAVAQFACSVVAGFVFGFIGIELLvg-----------------qlDFGFRLLLGVMIGLIVALSEIYFLAQ 220
XP_002013492 208 qikslnkqIIAVLQFVFSVAAGFTFGFFGVNLMvg-----------------plPFGFRILLGVIVALIIALAEMYFLAK 270
XP_003424813 139 qmklmnkqLIAVAQFVFSVMAGFAFGFIGVELIvg-----------------nlDFGFRLLLGVICSIVIALAEIYFLAK 201
EFN73800      65 qmkqinkqLIAVAQFIISVITGFVFGFIGIELMvg-----------------nlDFGFRLLLGIICALIIALAEIYFLAV 127
XP_001539928 246 YLRKVE 251
ELV12086     209 AVEgel 214
6_pfamImport 124 TMEG-- 127
Q19259       188 GMDMGE 193 Caenorhabditis elegans
XP_002433201 405 HLNEED 410
XP_003437151 274 KLNEEy 279
ETN63645     221 KLNEEd 226
XP_002013492 271 KLHEYD 276
XP_003424813 202 KLSEDy 207
EFN73800     128 KLSETd 133
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