Conserved Protein Domain Family
Git3

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pfam11710: Git3 
G protein-coupled glucose receptor regulating Gpa2
Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail. This is the conserved N-terminus of these proteins, and the C-terminal conserved region is now in family Git3_C.
Statistics
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PSSM-Id: 371685
View PSSM: pfam11710
Aligned: 18 rows
Threshold Bit Score: 200.981
Threshold Setting Gi: 220700383
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDO18421      49 LLKLRILSIVFAFISLVTGMVGLFLLWNIDRRRK-------------SFRHELLLYLIICDNIKTLISVIYPMILLIrrQ 115 Vanderwaltozyma...
Q6C142        45 NRSLRIVSICFSSLSLLAGTYGIFWFFYHQYKKRhltknagfrsrviKFRRKLVLALILFDFLKALMLTIYPAKKLC--G 122 Yarrowia lipoly...
Q6BJR3        37 ADRQRVISIVSSSTSIFAGLVGIYFFLAISDRKR-------------IFRHHLIILLILYDWMKAICLLLYPVRVLVtsK 103 Debaryomyces ha...
Q6C970        25 QLVQRICSVVASCVSIVFGLFAFYLFINM--RKK-------------VFRHHLIFLLLTFDFGKAVVLLWYPVRVLQvkS 89  Yarrowia lipoly...
Q6BPB1        44 TWMQRVLAISSSSTSIVFCLVSLYAFLAIDPRRL-------------VFRHQLIAFLLSFDLLKAVVLLLYPSLALSydL 110 Debaryomyces ha...
EDK45611      13 PRARPYLRF----------LVALYFLSAIDPKRL-------------VFRHQLISFLLLFDLLKACILLIYPTRVMThtS 69  Lodderomyces el...
XP_001386128  64 ALVQRILATSSSCASISLCLAAFYSFLAIDPRRL-------------IFRHQLIFFLLSFDMLKAVILLLYPTRVLThsS 130 Scheffersomyces...
O94744        27 LANLRIMVIIASAISIVFSLIAIFWRWS---RRR-------------TIREQFHIALFSVLFIRSIVQMIHPCLALSdpF 90  Schizosaccharom...
XP_001590503  35 GYLSQKLALTFSTVSVASSLLAFYWFVRM---RR-------------SFRHDLIMLLIQSDMFKALWFMVFPIVVFLhgP 98  Sclerotinia scl...
Q7SAB9        42 TDDLAVVSLTFASLSLILTLSTFYWFVKM---RK-------------TFRHELIVLLIQSDLIKSVWFVIPSIVHLVrgP 105 Neurospora crassa
EDO18421     116 ARGIPALYNVLGFLTAFAIEGA-----------------DFAIMVFALHFAILIFKPNYk------wINKRTNNVEGGLY 172 Vanderwaltozyma...
Q6C142       123 TPDSPQFAAVIGWFTNVAIEGG-----------------DMSAFLLAVQTAMMVFAPQNehskdnlwNRKFAKYFQNGLY 185 Yarrowia lipoly...
Q6BJR3       104 AYYDVGFCRVVGFFTAFSIEGS-----------------DLAIISFAIHLALLVYRPND--------RIKRGINYEGGLY 158 Debaryomyces ha...
Q6C970        90 SYNNVNFCEIVGYFTCCFIEGA-----------------DLAVLALALQTGVVVYK--------------KDTGAMGGLY 138 Yarrowia lipoly...
Q6BPB1       111 SYYDPTLCQVIGFFTAVAIEGA-----------------DLAILAFAIHTFLLIFKPNLs------iRVGNSGFVEGGLF 167 Debaryomyces ha...
EDK45611      70 SYYNRKFCQVVGFFTATAIEGA-----------------DIAILSFALHTYLLIFKPSLn------mKLPHLNRVEGGLY 126 Lodderomyces el...
XP_001386128 131 SYYNDQFCQVVGFFTATAIEGA-----------------DIAILAFAVHTYLLIFKPSLs------tKVKNSTRTEGGLY 187 Scheffersomyces...
O94744        91 FWAPKHRCFTIGFFLLVLVRMT-----------------DYWIFINILHNALLVLFP-------------HVDTERRGLY 140 Schizosaccharom...
XP_001590503  99 VADNSKFCQISGFFLAVGIEASgsiyysvgistfinsstDISVLMVAVHTALYIFKP-------------KSSAGEGGLY 165 Sclerotinia scl...
Q7SAB9       106 LRSDSALCQIAGFGLALGIEAS-----------------DIAVLLIAIHLLMTILRL------------------RTGLY 150 Neurospora crassa
EDO18421     173 KYRYFIWLIAL-LTPIVLASLAFIDfneiyfqiaykytnitednnyfgfgfqaRKGGYKPLAVQCYLPPVPYWYKLALSW 251 Vanderwaltozyma...
Q6C142       186 PYRKYIYVFCFtIFPTLLSSLAFVGtsypa-------------------aqdlGFRGYVPLPTFVFLPASPTWYRAVLSW 246 Yarrowia lipoly...
Q6BJR3       159 RYRYIVYPVEI-LLPIVLASLAFID-----------------------------NLGYTPLTNWCYIPSRPIWYRLVLSW 208 Debaryomyces ha...
Q6C970       139 KWRKYVYATVV-CVPILLASLAFIDr---------------------------GRTAYVPMVTWCYLPAKPYWYRLVLSW 190 Yarrowia lipoly...
Q6BPB1       168 KYRYYVYGLSF-VIPIVMASLAYIN-----------------------------KLGYDSLICWCYLPRSPTWYRFVLSW 217 Debaryomyces ha...
EDK45611     127 KIRWLVYSLSI-VVPLVFASLAFIN-----------------------------GTGYDSLVCWCYLPERPVWYRLVLSW 176 Lodderomyces el...
XP_001386128 188 KFRFYVYVMSF-LIPLVLASLAFVN-----------------------------GTGYISLVCWCYLPQRPVWYRFVLSW 237 Scheffersomyces...
O94744       141 RFRHTVFTLSF-VIPLTIGGLAFTN----------------------------KRNTFVNLQTRCYLPYTPVRFMFGLNW 191 Schizosaccharom...
XP_001590503 166 PYRKIAYTIWI-LFPLLAASLAFVN----------------------------NREAYVAQGTYCYLPVRPFWYQLALGW 216 Sclerotinia scl...
Q7SAB9       151 RYRYWAYGAYC-FFPVLFASLAFVD-----------------------------GTGYQEAGHYCYLRTDKSWARRALSW 200 Neurospora crassa
EDO18421     252 IPRYVLIVSIFGIYISIYVYVSRESSKI 279 Vanderwaltozyma polyspora DSM 70294
Q6C142       247 GPRYFIMFAIFAIYIAVFIHVRREFKRL 274 Yarrowia lipolytica
Q6BJR3       209 IPRYIIMVSIIIIYICIYQHVTKQYSSV 236 Debaryomyces hansenii
Q6C970       191 VPRYCILIIIIAIYVSIYIHVKREYDTA 218 Yarrowia lipolytica
Q6BPB1       218 VPRYIIVIIIITVYCVIYFHIIREFKVV 245 Debaryomyces hansenii
EDK45611     177 VPRWCIVVAIFLIYGMIYFHVIKEFKIL 204 Lodderomyces elongisporus NRRL YB-4239
XP_001386128 238 VPRYCIVVIIFVFYALIYYHVIREFKTL 265 Scheffersomyces stipitis CBS 6054
O94744       192 SFDYALSIAIIALQTCMFISIRRKIKRF 219 Schizosaccharomyces pombe 972h-
XP_001590503 217 IPRYIIFVTILTVYASIYYYVRFRFRGF 244 Sclerotinia sclerotiorum 1980 UF-70
Q7SAB9       201 VPRYIICCSILAIYLFVYFYVRSRLEDY 228 Neurospora crassa
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