Conserved Protein Domain Family
Npa1

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pfam11707: Npa1 (This model is not part of the current CDD release)
Ribosome 60S biogenesis N-terminal
Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.
Statistics
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PSSM-Id: 519840
Aligned: 108 rows
Threshold Bit Score: 180.89
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007874786   63 CKEIFELWMYFHQNNDFPIVSLILEILIFVI---RIIG-L--------LGSYTTGNKIIKRILDF---HIKSIYRNLSSN 127 
9_pfamImport    1 CAEMFKLLDGEKRSESE-MLLVFQTLEAILL---RTASdL--------SHFSVVGMNIVKKLIHG---YMQLLYGALQSE 65  
XP_018873302   78 CVEIFQLLSGEKRPESE-MMLIFQVFEAILL---RTASdL--------SHFHVVGTNIVKKLMNN---HMKLICESLYAS 142 
XP_003056485   25 FEDILALWDAYHNTNTQRVCVPLMLLVADLL---RHTPeDrtae---rgfiHLQLDGLARSILQR---RMRAVYSHLNSS 95  
XP_015583240   86 FSELFAALKLREGKS---GTHYIFKLISVIL---GHPEgKfipndkgrIGISVGLDKFARSFLEE---KLDFVYKDLVSK 156 
XP_010644440   95 FSELQDAWKRWQGKP---GMSYILSLISAIL---SHPDgIyrpndtrrIAISRIIDKFARSIVEE---KLEDIYKELNSK 165 
Q54RN6        112 MTEIFKIWDLCIDKYQ--IYQNVYSLLLEFIailITINdD--------PSLSHYSKILADKILSNkfqDLLKLINNYTDE 181  Dictyostelium...
XP_003283314  106 LTELFTIWDTCIDKYQ--VYQTCYALLLEFLaiiITLNdD--------PALQFQTRILADRIITNrflDLQKIINSYSDE 175 
XP_003640527   74 CAEIFKLLDGEKKPESE-MLLIFQALEAILL---RTASdL--------SHFSVVGTNIVKRLIHS---YMRLVYAALYSE 138  chicken
XP_018667840   94 CYEVFKIIETGKTSPMV-TSLVFEVFVNVLL---RTAGdLs-------PTFGSVGTTICRRILQG---HTRELYGTLSTK 159  vase tunicate
XP_007874786  128 IDIL-VIGTLRL---LIEMSCfNLGSFVLEIFKSFDFSH--KVISKIMKNF----SkvSINTSSRINARflafETPRTFM 197 
9_pfamImport   66 SySFqSGVCLSLgpsFKLQVS-PPSENRASVTQRLLHVM--NTLFFFF--F-------------PKQGR----PDVRVAF 123 
XP_018873302  143 GYRL-ARACLSL---MTAMVT-QGPEAARDVCSHFDLNK--KTLYTLVTKR-------------DSKGV----YDVRQAY 198 
XP_003056485   96 IRIR-QKCAMTL---CISITA-RSRQLAWDVFRNLDFTL--AAFAKLSKPPryqiNctWDSTTETRSSHdasaLPTRHIF 168 
XP_015583240  157 DKKR-QNAALSV---MDSVVR-RGSGLASEVAKKFDFKL--KGFSKLSEYKplknEnkRRRSTDDEKRK----YITRKAF 225 
XP_010644440  166 EGKH-QKAALLL---MASIVR-RSSSLASEVAKSFNFKF--PVFPKLAEYK---------LKQVEKKRK----HSTRKSF 225 
Q54RN6        182 TVNL-TLNCFRL---LSSIVP-LSLKIAKSIQTNIDFSS--QGFQKAM----------------NDISIngayLGTRPYV 238  Dictyostelium...
XP_003283314  176 TVNL-TLNCYRL---LSSIVP-LSIKIAKSLQTNIDFSS--NAFQEAM----------------TDIPSngayLGTRPYV 232 
XP_003640527  139 NHRM-SRVCLTL---LSAMVA-QGPDTARDVFSHFDFNN--KFLPALVKKR-------------DKKGR----PDVRMAY 194  chicken
XP_018667840  160 NPPKfRAPALRV---LTAMVM-QGAECAADVASNFDLSGniTLLSK--TRK------------DDSKNKlkpeSNIRLCF 221  vase tunicate
XP_007874786  198 IRFIFCFLEFGPISLKLELFGYKNIFYDIFSGL-VKDDLSFMQKVLDIILQFVIFEK-GIPRSIKMSIFNEN-VLNE--L 272 
9_pfamImport  124 IQFALSFLIAGDNAIIGQVLELKDFLMDVFSSGlKEDRISAVSILLSTLKTKVKISL-SLVKLSWKSFASGQ-QILHskL 201 
XP_018873302  199 VQFALSFLIAGDDSTIVQVLEVKEFIPCIFSSGiKEDRISTINILLSTLKTKVVHNK-NITKTQKVRFFTGQ-LLNH--I 274 
XP_003056485  169 VEFVMVLLSSGDVSLLRCVLTQKVLLGNVLRHL-ASDPVPLASRVLRVMCDNVIVDGsGVSVRLQAALFSDR-VLGQ--I 244 
XP_015583240  226 IAFAMSFLEVGKPGLLRWVLQQREVYSDILRGL-GEDDDETVMYVLSILRDRVLTEEsLLPPALRSVLFGSV-VLEQ--L 301 
XP_010644440  226 IGFAMSFLEVGKPGLLRWILQQKEMYSGVLRGL-GSDDVETVVYVLSTLKDRVLIPEsLVPPGLRSVLFGSV-TLEQ--L 301 
Q54RN6        239 LRFLLSFLKHHNIKLSEFILENDQLLVKYCQKL-QLDHHNVILDLIESLEVNVLKVS-NVSKILKIKFFSTS-FLSK--I 313  Dictyostelium...
XP_003283314  233 LRFLLSFLKHHNLKLSEFILESEYLLSKYCHKI-QLDHHNVILDLIESLETNILKVD-IIPKKLKIKFFSPS-FLSK--I 307 
XP_003640527  195 IQFALSFLIAGDTAVLIQVLELKDFIPDIFRSGiKEDKVSTVNLLLSTLKTKVVQNK-NITKTQKVRFFTAE-VLNH--V 270  chicken
XP_018667840  222 IRFVLSFFMTGDQKTIRQVLEARGFVDSVFRGL-PEDSASVIQLFLTTLLENVVKNK-AVPKTNKVKLLASHgVLTS--V 297  vase tunicate
XP_007874786  273 IALYSETDD-------G-----------ISRSMAIHNFLILLCTKHGMGICF-----E-CN-GWYPK------LE----- 316 
9_pfamImport  202 ASVLLFYGVsgtgvedPkea------gkVMVRELVHSFLLDLCCSLRHGINFyd-------------------------- 249 
XP_018873302  275 ASLYNWNGItdvnpedVkvsae--eagkTMVRELVHNFLMDLCCSLKHGINF-----YdASlGTFGRg------------ 335 
XP_003056485  245 VAISGRQAEavsgtkgIsk--------aACAAELAHSLLLRLCTDPVHGFRR-----EnAS-GRFVGakeeisLGsmseg 310 
XP_015583240  302 ADISEKRYGg-------------------pTANLAHNVLLMVCTDPCNGLMPdlkrrPnALkG----------------- 345 
XP_010644440  302 VSISGREDGg-------------------pASELAHRVLVMVCTDPCNGLMPdlkrhPyPLrG----------------- 345 
Q54RN6        314 GLIFSKDDIge------------------dCRQSIFKFLSILCCSSTHGIIS-----SdPKwTWFRDnen---------- 360  Dictyostelium...
XP_003283314  308 GLVFSKDDIge------------------eSRQSIYKFLTTLCCSPIHGICS-----SdPKwTWFREndl---------- 354 
XP_003640527  271 ASLYRWNGItdvsskdFkvtegseevgkAMVRELVHNFLMDLCCSLKHGITF------------YDPslgtsgRG----- 333  chicken
XP_018667840  298 AKLFQWNGImdvkvdeEdr--------nSFVRNLAYEFLYQSCCPFKHGINFyd-------------------------- 343  vase tunicate
XP_007874786  317 ------------------------TDFKKNK----SLl------iYNKNLSSFIFKLK-ITQDILQQELFLKICQACPEL 361 
9_pfamImport  250 ----------------------------------aSLgtdgrsvpGNLVLLRFILGLKtATEDELVAELLVSILKVCPDL 295 
XP_018873302  336 ---------------------------------------------GNLTLLHFLLGLKtAADDDLVADLVVNILKVCPDL 370 
XP_003056485  311 hlqargavksgkassitkieysspVINAITTgyarEVd------eRNETVLRLLRKLK-PTESRRHAEMLLEVCSKQPNI 383 
XP_015583240  346 ---------------------------------------------NSKRLLQLMKKLK-AKEV-FHRELLLAIVRGRPSL 378 
XP_010644440  346 ---------------------------------------------NPKRLLGLMKKLK-ATEVAYHRDLLLSIVKGRPSF 379 
Q54RN6        361 ------------------------------------------psfENKSLVSLISELN-PIAYQTHQTLFIKIINSCPDL 397  Dictyostelium...
XP_003283314  355 ------------------------------------------psfENKSIVSLITELN-PIAYQTHQSLFIKIINACPDL 391 
XP_003640527  334 ---------------------------------------------GNIVLLRFLLGLKtATEDEMVADLVVNILKVCPDL 368  chicken
XP_018667840  344 ----------------------------------rEYgts--grsSNHVLHKFLVDLKvTGSNDQAHTLVVEILRSCPDL 387  vase tunicate
XP_007874786  362 IA-YCapqfsLNIRFEPHLTISWLSI 386 
9_pfamImport  296 LHrFFk---eTKYSFVPRLKSAWLDN 318 
XP_018873302  371 LNkYFk---eVTFSFIPRAKSTWLNN 393 
XP_003056485  384 AAsYIp---hATYSLEPRLSWSWITA 406 
XP_015583240  379 GSaYLe---eFPYNLEDFASPNWCST 401 
XP_010644440  380 CSaYMd---eFPYKLEDHTSSTWFAA 402 
Q54RN6        398 FTsYLk---kLG-TCEVSLSLNWLNR 419  Dictyostelium discoideum AX4
XP_003283314  392 FTsYLk---kLG-SCEVSLSLNWLNR 413 
XP_003640527  369 LNrYFk---eTQYSFVPRVKSAWTDN 391  chicken
XP_018667840  388 LStYLm---sADLSFDPRPTKKWYDN 410  vase tunicate
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