Conserved Protein Domain Family
RNA_pol_3_Rpc31
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pfam11705: RNA_pol_3_Rpc31 (This model is not part of the current CDD release)
DNA-directed RNA polymerase III subunit Rpc31
RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.
Links
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Statistics
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PSSM-Id: 519838
Aligned: 84 rows
Threshold Bit Score: 40.782
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ERT01182       22 APWs-DD--LTMK--ADSR---PVELFPAY-SAPMAAPLTQQECQAVDYFLLVREQTHSTPLYTQTRTWKSlegagsggp 92 
XP_001984653   16 EQMqaLGcvGKDMpqVQSA---PPPTFPPVlNKPITLETTASQNYQLLWKEDFLNRMRDSPYYIISASQEKq-------- 84 
XP_049544949   16 EQLqsLGvtSKEIqtVTSAa--PPPVFPVLlSKPVSLESSVDRNYKILWKEDFISYLRESAYFTTKKCSKL--------- 84 
Q16WK0         16 EQLqsMGvtRNEMqaVSSAa--PPPLYPILqSKPVPLESNADRDYKILWKEDFISYLRESPYYTTVKSSK---------- 83  yellow fever m...
XP_002427981   18 FDYnqLG--FGGGeaLPAPalyPPPTFPILeHKPLPLKTGAETEYMVALKRDFV------EYFQSLRQNNNc-------- 81 
19_pfamImport   1 FNIeaLG--LNRGsmPETQr-gPRPMFPEVeFKPVPLKAGEAEDYMLALKQEIRGKMKGLPF------------------ 59 
1_pfamImport    1 FNVeaLG--IGRGsmPESNvtrKKPTFQNTdFKAVPLKAGEDEDYMLALKQEMRGTMQRLPHHIKHLSNKS--------- 69 
20_pfamImport   1 FNVeaMG--LGKGepLPPStlqPTPLFPPMeNKPVPLQAGEEAEYMLALKQELRGAMKNLPYFVRPAVPK---------- 68 
XP_011151179   13 FNTeqLG--VNKGelPPQVl-qPPLPYPMLdLHVSNFESTNEINYLVELKRDFAEYMRDSL-NNITPEVMK--------- 79 
XP_011614351   13 FNIeaLG--IGRGsmPDARv-gPSPLFPTTdFKPVPLKAGEEEDYMLALKQELRGAMQRLPY------------------ 71  torafugu

ERT01182       93 ggggasgkaygqdqinrqygvrnkaTVDPF-TSVPMYSHRFQ-TTERALP-DLS--GRPFSKALFPP-ELWPTLdgnddg 166
XP_001984653   85 ------------------------------kSSVKDWREKAL-ERLKNKA------EPEFNYKAMPR-EVNTTS------ 120
XP_049544949   85 --------------------------------SVQRYSDKVI-NVIENDPkTKH--DGDFLWSCMPA-ELMPNF------ 122
Q16WK0         84 -------------------------------GPVQRYSDKVI-NVIENDPkRKC--EGDFLWSIMPA-ELKPTFkrtk-- 126 yellow fever m...
XP_002427981   82 ------------------------------lSAIERFSDKYQ-MISSELK-ESS--DSQIYWDALPA-ELHPNW------ 120
19_pfamImport  60 -------------------------NIKP--RSVEKYKEKYV-KEYSKIC-DEE--WTP--WNRLPK-ELMPQK------ 99 
1_pfamImport   70 -----------------------------VeTEVERYTERYL-KQKLMEDkDWSpeWSLLPKELMPQkKKTCTK------ 113
20_pfamImport  69 -------------------------------KDVERYSDKYQ-SSEPTDN-TIE--WTP-DWNRLPR-ELRIRVrkp--- 108
XP_011151179   80 -------------------------------KDIERYSDHYQdVLDNSEQ------KPKYDWSRMPE-ELAPSLkrka-- 119
XP_011614351   72 ---------------------------------------------------NIK-----------PL------------- 76  torafugu

ERT01182      167 rlgkgGAGAKNMRDRvlALSDVTSLRTAEDifqtkkaedsADGESGTHKALEQLEKFKNVGLDNEDNve-----fDLVED 241
XP_001984653  121 -------RKRRAAEP--RPKLVAKKTNIED-----------------RLKQLEQKELKSSGDNENDEv------kQESDS 168
XP_049544949  123 ---------KRAKQMn-AASKPKRPRTVED-------------IDATLQALEQKESTAAKAEGAKKEk-------SETDD 172
Q16WK0        127 -saanGASKGAKKSK--VVDINAKLSELEQ-------------------KESFLDDTDVKKEKASDS--------EDEKD 176 yellow fever m...
XP_002427981  121 -----KKALKRKSRM---QSCTEPKKSNID-------------------ISSRLEKLAKLEDKEENEsedmkeseDKDGD 173
19_pfamImport 100 -----KKIIRKTSKK------SKSLSSNDK--------------EVLLSKLDELEKKGDDKSDEEKEes----gkKKAGE 150
1_pfamImport  114 -----PGSKKKTVKIs-GKDAADMLNKLDN-------------NLLLTLFQNLAKKDEGNPEKSDDEte----kkTGNAE 170
20_pfamImport 109 ---pkETVKRKVKEPl-QVPKRSQQKRVDKe--------eIIRKLEVRTVQTLEKKEQEVSSEEEEE--------EKKQE 168
XP_011151179  120 -tsslKAGNNQKMKT---NTKRKRPRVIDD-----------DDDDDNKQGTEEKPKQQKNTKQAQDNiek---eiKEEEE 181
XP_011614351   77 -----------------------SNRAAEvekytqryikqsqrtneewtpdwnllpkelmprkrrvgaeagttkktrisq 133 torafugu

ERT01182      242 EGDYD---EVEDEEY--DDDEEGDYnAEAAFDNGDD 272
XP_001984653  169 EHEDEpedPEAALDD--EMDEENDY-ANDYFDNGEA 201
XP_049544949  173 ENEED---LEEEIVDe-EMDDDNDY-GNNYFDNGEA 203
Q16WK0        177 DEEQE-----EEVADe-EMDDENDY-GNNYFDNGEG 205 yellow fever mosquito
XP_002427981  174 DDNDKenlETEEDDDe-EMDDGTDY-VNNYFDNGES 207
19_pfamImport 151 EDEEEv--EGEEFDEe-LEEQENDY-IASYFEDGDD 182
1_pfamImport  171 EDEED---IEEDIEEe-DVEEENDY-IDSYFDNGED 201
20_pfamImport 169 EEEQE---NEEEYDEe-EFEEETDY-VMSYFDNGEE 199
XP_011151179  182 EDEENsdeEMEEYEIdeEMDDGTDY-VNNYFDNGEG 216
XP_011614351  134 kvnqdilnkledlekkdrnpeksddetekkaeneee 169 torafugu
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