Conserved Protein Domain Family
RNA_pol_3_Rpc31

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pfam11705: RNA_pol_3_Rpc31 
DNA-directed RNA polymerase III subunit Rpc31
RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.
Statistics
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PSSM-Id: 403033
View PSSM: pfam11705
Aligned: 91 rows
Threshold Bit Score: 38.5946
Threshold Setting Gi: 761912777
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT01182       9 RGGgrggr-rggfGAPWS--DDlTMKadsrPVELFPAY-SAPMAAPLTQQECQAVDYFLLVREQTHSTPLYtq-trTWKS 83  Sporothrix sche...
XP_011405594   5 RRRgsgrpasnleGLGVPpgERiPPPsl-ePSPLFPPLdKRPLDLTDNELYVELLGKKSSLRVAMQDSVFYlr-ksQRDH 82  Amphimedon quee...
XP_011451455   6 RGRgknvs-fnveALGFGrgEAlPGPis-qPPPLFPTAdFKPVPFQQSEEYDYMLALKQEFLGNMRKSPFFlqashKRK- 82  Pacific oyster
NP_001102938   5 KGRgraaytfnieAVGFSrgEKlPDVvl-kPPPLFPDTdYKPVPLKTGEDEDYMLALKQELRETVKRLPYFietpeEKQ- 82  Norway rat
6_pfamImport   1 KGRgraaysfnieAVGFArgEKlPDVvl-kPPPLFPDTdYKAVPLKTGEGEDYMRALKQELRETMKRMPYFietpeEKQ- 78 
5_pfamImport   1 RGRgigafsfnveALGIGr-gSmPESnvtrKKPTFQNTdFKAVPLKAGEDEDYMLALKQEMRGTMQRLPHHikhlsNKSV 79 
Q1LWT2         6 RGRgrnqftfnvdALGFGrgDSlPTTth-tPSPLFPPMqFQPVPLHTGEEVEYMLALKQELRASSKNLPFHiraarTKR- 83  zebrafish
8_pfamImport   1 RGRgraalsfnveALGIQqgEAlPGPvl-qPPPSYPALeTVTAPIYPSLKFGETLQYKKDFLNFYTRLRVDyeevaTSG- 78 
XP_006641817   6 RGRgrgqmsfnveAMGLGkgEPlPPStl-qPTPLFPPMeNKPVPLQAGEEAEYMLALKQELRGAMKNLPYFvrpavPKK- 83  spotted gar
XP_005457540   4 KGRgvgaftfnidALGIGr-gNmPEArv-gPSPLFPSTdFKPVPLKAGEDEDYMLALKQEMRGTMQRLPYNikpqsNKA- 80  Nile tilapia
ERT01182      84 LEgagsggpggggasgkaygqdqinrqygvrnkAtvdpftsVPMYSHRFQTTERALPDLSGRPFSK---ALFPPELWPTL 160 Sporothrix sche...
XP_011405594  83 EL-------------------------------N-------IVRYSDKYKTKDETDIMEILASTPSw-qQRLPKELHPKT 123 Amphimedon quee...
XP_011451455  83 ---------------------------------D-------IERYSDKYQAAAEVNG--KWKP--Dw--RRLPAELKPRV 116 Pacific oyster
NP_001102938  83 -D-------------------------------D-------IERYSKRYMKVYKE----EWEP--Dw--RRLPREMMPRK 115 Norway rat
6_pfamImport  79 -G-------------------------------D-------IERYSKNYMKIYKE----EWVP--Dw--RRLPRELMPRK 111
5_pfamImport  80 ET-------------------------------E-------VERYTERYLKQ-KLMEDKDWSP--Ew--SLLPKELMPQK 116
Q1LWT2        84 ---------------------------------D-------VSRYSDKYQTGEPKNNTIEWSP--Dw--SRLPKELCIKV 119 zebrafish
8_pfamImport  79 ---------------------------------N-------KRRFDSTSISATQN---KKERPQLNyewTRFPVELRPGT 115
XP_006641817  84 ---------------------------------D-------VERYSDKYQSSEPTDNTIEWTP--Dw--NRLPRELRIRV 119 spotted gar
XP_005457540  81 ---------------------------------E-------VERYTERYLKQ-SQIDDNEWTP--Dw--NLFPKELMPRR 115 Nile tilapia
ERT01182     161 dgnddgrl--gkggagakNMRDrvlalsdvtslrtaedifqtkkaeDSADGESgTHKALEQLE---------------KF 223 Sporothrix sche...
XP_011405594 124 krtikkaqrhkkalkptsGTQF------------------------GTs-----KLNIADTTSpp-----------lgDT 163 Amphimedon quee...
XP_011451455 117 rrktkssi--kpsvkvksKVK-------------------------------LsVEDVSKTLEele-----------kke 152 Pacific oyster
NP_001102938 116 kckkadpk--skaakatsK-G----------------------------TTLMnSTDVLKKIEele-----------rrg 153 Norway rat
6_pfamImport 112 kckkvgpk--skkatdagK-V----------------------------TSLTnTADVLKKIEqiqe----------kkn 150
5_pfamImport 117 kktctkpgskkktvkisgKd----------------------------------AADMLNKLDnnllltlfqnlakkdEG 162
Q1LWT2       120 rkprktitgtkqqlkqrpKVA-------------------------------AsKEDILQKLEtl-------------ek 155 zebrafish
8_pfamImport 116 tkrpkk------ipkvkiKa----------------------------------MADIDKMLAqle----------qkeN 145
XP_006641817 120 rkppk---------ekplQVPK------------------------RSQQKRVdKEEIIRKLEtle-----------kke 155 spotted gar
XP_005457540 116 krpqaktgt-kksakisrKd----------------------------------TENILTKLDela-----------nkd 149 Nile tilapia
ERT01182     224 KNVGLDNEdnvefdlvED-EGDYD--------EVeDEEYDDDE----EGDYnAEAAFDNGDD 272 Sporothrix schenckii ATCC 58251
XP_011405594 164 ITVGSIDLini---raGYtEGEEEvg-----eeEeEEVYD-EEeeeeQGDY-QLSYFDPGGD 215 Amphimedon queenslandica
XP_011451455 153 VDQGDEEEeee---eeGAkKKEEGev-----eeEeDEIYD-EEdieeETDY-ILSYFDNGEE 204 Pacific oyster
NP_001102938 154 EGERSDEEnde---keGSkEKEKDeeedgeedAe-QEEYD-EEeqeeENDY-INSYFDNGDD 209 Norway rat
6_pfamImport 151 QSNRHKCNnsr---kaGSkSRDKIssqkndfhSEcEDGPN-REqreqENDY-INSYFEDGDD 207
5_pfamImport 163 NPEKSDDEte-----kKTgNAEEDee-------diEEDIE-EEdveeENDY-IDSYFDNGED 210
Q1LWT2       156 EEVHSEEEede---gkKKkQNDDEee-----epEvEEDYD-EEeledETDY-IASYFDNGED 207 zebrafish
8_pfamImport 146 AMFNADESvvk---veKPqDEDNEdee---gmGEeEVEHDSDQemdeGTDY-NSNYFDNGES 200
XP_006641817 156 QEVSSEEEee----ekKQ-----Eee-----eqEnEEEYD-EEefeeETDY-VMSYFDNGEE 201 spotted gar
XP_005457540 150 DPEKSDEEte-----kKPrN--EDeee------ieEEEYE-EEdieeENDY-IESYFDNGED 196 Nile tilapia
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