8BRG


Conserved Protein Domain Family
UNC45-central

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pfam11701: UNC45-central (This model is not part of the current CDD release)
Myosin-binding striated muscle assembly central
The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organised myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.
Statistics
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PSSM-Id: 519835
Aligned: 93 rows
Threshold Bit Score: 70.2664
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8BRG_A        69 QLEFLCRRILL----------RSSiQEIRPLLLVTMKSLMSNHSDNTEQKCGNILQQLLie------------------- 119 Kluyveromyces l...
XP_001382314 148 HLHVLLKFINPipvilsesgeSDY-KTIVSLVMMILVKNLQANKKTTCEVITEYLELIKe-------------------- 206
XP_007375001 135 HLNLFLTFAN------------SD-AALHRSILVLVIQNLKLEKEKTSEIIKEYLEVVCd-------------------- 181
XP_002546885 189 HLNLFLTYIDG-----------KD-KEIQQAVFVLIIQNLKLQREETSNIIKDYLDVQMd-------------------- 236
EMG51036     138 HLNLFLTFVDG-----------KD-HDVQQSVLVLIVQNLKIQKSETSEIVKEYLEVLMe-------------------- 185
EDK43108     147 HIGLFLTLVG------------KI-AKVDHLVLIIVVQCLQIEKANTIEAIKDYLEVQIgdeaddvgrtsgdsdsgsgsg 213
XP_001483086 137 HLDVLLSFIGPen-------gSEQ-LNLTPIILLITIKSLKLAPKPTTDTVTVFVEFILde------------------- 189
Q6BNL5       141 HVSLMLQYLNPfhnq---tneEKA-HEVYSLVLVIIIKNIELLAKKTTEVISSYLEILVdn------------------- 197 Debaryomyces ha...
CCE88963     135 HLPIFLKKLNVssek---enrELL-RSIEATVLVLVVRCIQQKQVDARAEVSEYLELLFdd------------------- 191
XP_036666676 133 HLNLFLTFVC------------EN-KDINNAVLVILAHDLELNKKESTETVHEYLQLHMd-------------------- 179 Candida parapsi...
8BRG_A       120 -----------aeEDSGNVSLRLLVDAMSLVFPICLGVCRDMFLSTDFQDILTRNLnSSa-----------DDEHLVNGA 177 Kluyveromyces l...
XP_001382314 207 ------------dESPTAAEVLNYIELLENLYPLIPEVIEPIYTCDKSKNLITAEV-DRvlesggreleypNRRRVCISI 273
XP_007375001 182 ------------eKYLDKESFLNFLIVLEMCFPLLPEVCAGVYGDDKTKQHIMSKM-ELap--------dlESMRY---I 237
XP_002546885 237 ------------dTSLTYNGFLNFITILEMCFPIVPDICTIIYQDDKTTRHLLDRI-SSit--------egNNTTFSIPM 295
EMG51036     186 ------------eNSLSSASFLNFVLVQEMCFPVIPEICSPIYQNDRTKSHLLEKI-TSil--------egNYLQLTIPI 244
EDK43108     214 ggniknndddeniPYIDGASFKNFLAVVEMCFPVIPEETTQIYTRKRTKEYFLEKk---------------HEKTFYIPI 278
XP_001483086 190 -----------dpVRVQRATFLNLVRVLESLYPLMPVPISTMYMSEKCKQMLLHHV-SSlsasv---ledeQNYRTVCEV 254
Q6BNL5       198 -----------epDKISMASFLNLVKSLESLFPIVPSVSQTIYMSESCKGIILFQV-SKmssts---leytSNQLITTEI 262 Debaryomyces ha...
CCE88963     192 -----------lhNDFKLANFLNFVRCLELLFPIEPSVVNAIYTKNDTKELVLKVI-SSvvekg---lgyqQNTIIAESL 256
XP_036666676 180 ------------eQSLDGLELKNFLLTLEMCFPLLPKMCSAMYCSSETKNHILDSF-SNh----------eNNPVTTIPI 236 Candida parapsi...
8BRG_A       178 LRLLAVSCIDEAVRRFIAEHYLKTLQQSFKVEK-----YKVLTALVLIKI 222 Kluyveromyces lactis
XP_001382314 274 LNLISSSCISETGRNYNVSTFLQLLKAGTMLKDi---eIKLLSTLNLIKL 320
XP_007375001 238 LKLIDSSCIVETCRNVNVTNYFQFLVQGCSFKNd---qIKVLSSLNLVKL 284
XP_002546885 296 IKLIDSSCIVENCRNYSVSNFFTFLSQSFESSNt---eIQVVSSLALAKL 342
EMG51036     245 LKLIGSSCIVENCRNYNVKNYLEFLVKGCEINNn---eIQVASSLNLTKL 291
EDK43108     279 LKCMSASCIVENCRKFNADNYKNLMENSFQSYDk---pVKVLASLVLAKE 325
XP_001483086 255 LRLVSTSCIDEELRNFNVKNYIQFLISGTKLSQkpfegLHLLSTLCIVKL 304
Q6BNL5       263 LKLVTSSCINEQCRLFNYNNYLELLKIGTKLQGenvlgIRLLSSLGIIKL 312 Debaryomyces hansenii
CCE88963     257 LHLISSSCTYEACRTFNIEHYLSLIKLGVHMESss-saLHLLSILCLVKL 305
XP_036666676 237 LKCVAASSISETCRDFTIKEYYSYLADSLKSQHv---rIRILAALSVVKL 283 Candida parapsilosis
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