Conserved Protein Domain Family
V-ATPase_H_C

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pfam11698: V-ATPase_H_C 
V-ATPase subunit H
The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the C terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.
Statistics
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PSSM-Id: 403027
View PSSM: pfam11698
Aligned: 116 rows
Threshold Bit Score: 102.201
Threshold Setting Gi: 429966256
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCK68651            357 ELTSFDEYLAEINSRLISWTPPHVDSSFWVDNIDRF-KQDN----WKLFKRLISLLieaqttattttdddtanERdGkK- 430 Kazachst...
EIM22891             29 sISNWDEYSSELESGLLRWSPVHTDEDFWKNQSGAL-LKDN----NWGLNRLFSLL------------------DsE-D- 83  Wallemia...
XP_009269931        303 sVSNWDEYASELDSGLLKWSPVHKDEQFWKNESRAL-LNNG----GWGVKRLLGLL------------------EsD-D- 357 Wallemia...
XP_001707099        408 KVTTWETYLAELKSDLLGNTPVHTSEAFWKANSHRL-LDNS----AYALNRLEQIGtk--------------aYk-S-Dt 466 Giardia ...
EHY66240            248 NISTFDSYLEELQSGSLQAHPYHFNTEFWKTNLDTLvLKR-----VDIIKSLKRFL--------------------K-Se 301 Nematoci...
ELA48253            338 NVSSVENYLKELYSGHLEPTLYHFEESFWNVNLTKLqIKK-----HEIIKAIRLYL--------------------K-Rg 391 Vavraia ...
EPR78963            333 NTSSINNYISELFSGRLEDAPYHYDNSFWENNIHVLlNNGNystiQGIFKALKKYLy-------------------R-Td 392 Spraguea...
WGS:AFBI:EDEG_01272 269 KSTCIDTYLNEMFSGCLEESPYHYSEQFWEANSAKLlENK-----EEILKAIKKYL--------------------N-Sk 322 Edhazard...
Q8SRF3              259 kkfcirNYLNELFSGRFEDSEYHHKKDFWSTNLDMLiKNK-----VEIVKVLKKYL--------------------K-Sn 312 Encephal...
ELQ75169            284 KTSSFQNYLRELFSGKLENTPYHFSDVFWSMNMNSLiEYK-----IEIIRALKKYL--------------------K-Sg 337 Trachipl...
CCK68651            431 -TrdrLVIQVLLNDITHVIELLPdESVDVLNKMNG-KVVIMQLLN-HSDSRVKYEALKATQSIIGYTF 495 Kazachstania naganis...
EIM22891             84 -Q---QILHITLYDISQCLKFIH-HAKTYV-DSSS-KQKIMELLQ-HPDPKIKYQALITTQLLISQPW 143 Wallemia mellicola C...
XP_009269931        358 -P---TTLHIALSDTASFLKYTP-TAKQHI-HTHH-KTAIMQLLQ-HPDNNVKYQALLTTQLLISQSl 417 Wallemia ichthyophag...
XP_001707099        467 nS-----LLVCLNDIGMFCISYS-NGRNVVAQMPNiKAFVMSCLQ-HEAETVRDAAIVTLSKVLVDNW 527 Giardia lamblia ATCC...
EHY66240            302 nH---NNIWIAANDIYRIIEVYP-ESIGLIRQMGV-HLVLFEILAaKTSEDVRFHAMEALSvcynke- 363 Nematocida sp. 1 ERTm2
ELA48253            392 eR---QNVVMALNDLLMFHNVDA-SIGRLIENYGV-KDQLIELCG-SNDNEIQFLALQAFLSVLNQql 453 Vavraia culicis subs...
EPR78963            393 dI---RSVCVAANDLYRIIKIAP-EIYPVVDKLNI-KQTLVKLSD-NNNEDIRFHALQTLSTCIFTEW 454 Spraguea lophii 42_110
WGS:AFBI:EDEG_01272 323 nP---QYICIASNDLYMFTKMSP-NISHLIAEYDI-KSDLFDLAKnSDNPDIRFHAIQALASCIFLDW 385 Edhazardia aedis USN...
Q8SRF3              313 nP---SWICLACSDIFQLVRASP-EINAVLSKYQV-REILFNLIN-SDNDDIKFHAIQALYTCISSEW 374 Encephalitozoon cuni...
ELQ75169            338 cT---QHKCVAANDLYRFVKACP-EIVRIVEKFDL-KTELFKLCE-STNDDLRFYALQSLSVCIFQEW 399 Trachipleistophora h...
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