5JAJ,2W4R


Conserved Protein Domain Family
RIG-I_C-RD

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pfam11648: RIG-I_C-RD 
C-terminal domain of RIG-I
This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.
Statistics
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PSSM-Id: 402994
View PSSM: pfam11648
Aligned: 70 rows
Threshold Bit Score: 89.2331
Threshold Setting Gi: 405963456
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5JAJ_A         559 FHCVNCNVAVCRGSDIRTvEAMHHVNINPNFRFYYTVSsGKIHFERTF-RDWE-PGCRIVCS----ECRQEW-GMEMIYR 631  chicken
XP_011672912   784 LLCKHCRQFACYTDDIRSiNGQHHIVIGEGFLDRVITE--RLQEEKNLyGDVT-VSKEVQCK----RCKKPL-GFMMIFR 855  purple sea u...
11_pfamImport    3 LLCKHCRQFTCFTEDIRSiNGQHHIVFDKGFQDRVITE--RLLEEDYLySDAK-ASKETRCK----RCKKQL-GFMMIFT 74  
PDM70147       938 ILCGNCNQRLCDSFRIKK-GSSHYFACDTQIWQLFQIE-FNDSKGKYVdLTTA-MVGKVLCKgdsgKCGHEL-GKVVRYD 1013 Pristionchus...
10_pfamImport    3 VICASCNKHFCKSTAIKKiY-SNYMVMEPEIWDHLDLVsRARKVNKMHaADCV-SLCNIKCK----HCKADI-GRAYKIR 75  
CAP28128       656 LTCTSCSSFFSRSTAVKKvY-SNYMIFDNDVWSRFGIEsRRKKPNRYLnEETQ-ALSVLKCL----SCKSDV-GKAYKMR 728  Caenorhabdit...
EGT46817       814 LNCVGCSTTFCMSSDIKKvY-SNYMAFDPAAWQFFTVEsKKKKPNSYLsEDTQ-PLSILKCA----KCVTTViGKAYKMR 887  Caenorhabdit...
XP_003095565   788 VNCAQCQWTFCKSTDIKKvS-SNYMAFHPMVWDNVSVEs-QKKAPSYRnEDTQ-PLSILKCH----KCQHLV-GKAYKMR 859  Caenorhabdit...
Q93413         950 LMCSNCSKEFCKSIYIKKvF-SNYMVFDPSVWRFLHVEs-KRKVSKYLsEDNQ-PLSDIKCF----HCKLDV-GRAYKIR 1021 Caenorhabdit...
XP_011446812  1071 LRCQKCSKYICMSNEVRKiQNAHHACICDDIKERVLGQ--RLPRPQFEdVDLKcAVGKLLCR----SCGSDL-GNISIYK 1143 Pacific oyster
5JAJ_A         632 NVTLPILSIKNFVVVTP-DE-----KKKYKKWSTVT--FPIEEF-SYLE 671  chicken
XP_011672912   856 EHELPLLAIKHLVIELPnKA-----KVHKKKWSETTsiFTIKDI-DLea 898  purple sea urchin
11_pfamImport   75 EHELPLLVIRYLVIELAnGV-----KVYKKKWSETTsiFTIKDM-DLED 117 
PDM70147      1014 GCYLPALKCASLQLRNKkDNkiegmDGKSTKWNDVC--KNTFYI-TQIS 1059 Pristionchus pacificus
10_pfamImport   76 GVYLPQLAVKELTFVPVhGNrm--dTETKGKWKDVE--EQLFFV----- 115 
CAP28128       729 GVYLPQLDVKAVTFAPEnHDe---gTTTRQKWSAVE--NDLFWIgEATQ 772  Caenorhabditis briggsae
EGT46817       888 GVYLPQIDVKSVFFVEEnSSe----SKTAKKWSSVE--QELFYVgEATQ 930  Caenorhabditis brenneri
XP_003095565   860 GVYLPQFAVKNVNFVAQnNDn---gTATKAHWSGVQ--DELFFIgEATQ 903  Caenorhabditis remanei
Q93413        1022 GTYLPQLSVKALTFVQEsDYs----SMTKAKWSDVE--QDLFYIsEAIE 1064 Caenorhabditis elegans
XP_011446812  1144 NAQFPILKIEGLLMEDNmGR-----RDVKKKWKSVP--FLVKEI-TAED 1184 Pacific oyster
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