6SL0,6JXA


Conserved Protein Domain Family
TAN
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pfam11640: TAN (This model is not part of the current CDD release)
Telomere-length maintenance and DNA damage repair
ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.
Links
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Statistics
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PSSM-Id: 519817
Aligned: 88 rows
Threshold Bit Score: 71.9724
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SL0_A          14 FKEIESHLVGSSATARKDAVEALIAYFDGSRT-------Q-SQT---------TFDDKAYHRLFEALFRCTLIEKEAYFN 76   Thermochaeto...
4_pfamImport     1 LRTILQALQEGKTTERKQAVEDITRYFQNPLKaa---nlG-------------TITQEDWKDVFGALSSAARQEHDGL-- 62  
XP_046449745    11 iietsKCMGSEKITERRKSAETLDILLSNQNYisv--ldDnTD----------ASHGFTWNNVFDAAIAYMSKEVEKFk- 77  
8_pfamImport     1 LLDCCRHLENDKATERKVNIQNSTRNTLNNQLviltpleKkDESk-------ySGRLFNWHGLFRYLQKFIQKETESL-- 71  
23_pfamImport    1 LLLCCRGLENEKATERKKEIDRFKRLLRDPET-------VkELDrtsalkasrNNNQLTWDAVFRFLKKYLQKETELLQS 73  
9_pfamImport     1 LLRYCRELESDKATERKKAAEQFRRLIHSAEVvqe--ldHtSGSnfq---tgqGSRQLTWDAVFRFLQRYVQRETESM-- 73  
XP_069045887     8 LLMCCRGLESDKATERKKEADKFKRLIVSPETvea--ldRaSSSra-----akGSKQLTWDAVFGVLRRYVERETEAL-- 78  
10_pfamImport    1 LLTCCRQLDSDKATERKKEIEKFKRLLRDSEI-------IqQLDqns---dskHGKQLNWDTVFRFLQKYIHKETESARL 70  
XP_003889212    11 LDEALSLLGSSTVTDRNQGVEQISNLLTNPSNw------N-------------SIKESRWAEIFHQLFSAADTEKAAI-- 69  
XP_025010458     8 LLTCCRRLENERATERRNEIENFKRLLRDPETvlq--ldRnSDSr--------RGNQLNWDAVFSLLKKSFQKEMENL-R 76   chicken

6SL0_A          77 SKK---SVKVTAaa--------aaRLERCPEALRLAVRHGVT---TIR-RKTARAIIDHIVQVLPGpdG---AYVMPLLA 138  Thermochaeto...
4_pfamImport    63 -------RGASKglda-----kkrKIEDISVAVRIVVATSIP---HLN-NVAIEVLVPLLLDLLsq----pgALANTTGQ 122 
XP_046449745    78 -----qDEAKGKvlsqaqktlrenHLKLSASSLLNVIVLAGErkpRLDvDIVLHHCLTALKDPF---------MLEKFGR 143 
8_pfamImport    72 -------QAAKAnvsattqanrqkKLQEISSLVKYFIRCANKrrpRLKcQELLKHVMDIMQSSY---------SCAAYGT 135 
23_pfamImport   74 GKA---NVSAITqan------rrkKMQEISSLIKYFVRCANKrgpKLKcSDLLAHVVEVMQSSF---------SCSAYGE 135 
9_pfamImport    74 -------QSGRPsasasvlttrqkKMAEMCSLIKYFIRRANKrgpRLKcSELLKHVTEVLQSPY---------SCAAYGE 137 
XP_069045887    79 -------QTGKAnvsattqanrhkKMQEVSSLLKFFIRCANKrgpRLKcTDLLAHLVGVLRSSF---------SCSAYGE 142 
10_pfamImport   71 AKPn-vSASTQAtr--------qkKMQETSSLAKNFIRCANK---RAP-RLKCQDLLMYFTNTVnd-----pSSYAIYGA 132 
XP_003889212    70 ------LKPSNArkgsiarasnlnRLRAALTLIRKCVVQFVS---LFK-HKVMKLVINRTIELIVV--AknrTLMDSIVL 137 
XP_025010458    77 LTKpnaSASTQTsk--------qkRMQEIGSLVKYFIRRANRrgpRLEcQELLNYVLHIIKDPA---------SCAAYGS 139  chicken

6SL0_A         139 GYVKVL-YEFLDNPASAENiaaLSGEGWE 166  Thermochaetoides thermophila DSM 1495
4_pfamImport   123 NYGRAL-QSIVAHGPHVRS---FKVKTWK 147 
XP_046449745   144 DHLTALnREILSKRGYWSK---LKPNSWL 169 
8_pfamImport   136 DYSSILlKDVLAVRKYWCE---ISQQQWE 161 
23_pfamImport  136 DYSSMLlKNILSVRKYWCE---ITQQQWH 161 
9_pfamImport   138 DYSSLLlKDILSVRKYWCD---MAPQQWH 163 
XP_069045887   143 DYSSILlKDILSVRKYWCE---VTQHQWA 168 
10_pfamImport  133 DCSSILlKNILAVRKYWCE---ISSQQWS 158 
XP_003889212   138 DCIRIL-RDFLLYRPHLEH---LGHELSA 162 
XP_025010458   140 DCSSILlKDILSVRKYWCE---ISQQQWP 165  chicken
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