6SL1


Conserved Protein Domain Family
TAN

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pfam11640: TAN 
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Telomere-length maintenance and DNA damage repair
ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage. It is classified as an EC:2.7.11.1.
Statistics
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PSSM-Id: 402988
View PSSM: pfam11640
Aligned: 96 rows
Threshold Bit Score: 72.3631
Threshold Setting Gi: 321477062
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SL1_A         14 FKEIESHLVGSSATARKDAVEALIAYFDGSR--------TqSQT---------TFDDKAYHRLFEALFRCTLIEKEAYFN 76   Chaetomium th...
EKC30280       28 VIVYCRELSSEKATERKKSLEKLKNLLHKKSvin--sldYnSQHgre---kvrERNALTWDDIIREVHSYVYLETQLLqk 102  Pacific oyster
XP_022534729    8 LLLCCRGLENEKATERKKEIDRFKRLLRDPEt-------VkELDrtsalkasrNNNQLTWDAVFRFLKKYLQKETELLQS 80   Mexican tetra
3_pfamImport    1 LLDCCRHLENDKATERKVNIQNSTRNTLNNQlviltpleKkDESk-------ySGRLFNWHGLFRYLQKFIQKETESLqa 73  
4_pfamImport    1 LLLCCRQLENDRAAERRKEVEKFKRLIRDPLtvq--cldRnSDAr--------QGKHLNWDAIFRFLERYSLKSRPTDrp 70  
XP_008116369    8 LLTCCRQLDSDKATERKKEIEKFKRLLRDSEiiq--qldQnSDSk--------HGKQLNWDTVFRFLQKYIHKETESArl 77   green anole
XP_002934974    8 LLLCCRQIETDKATERRKEIEKFRRLLRDSEtvq--qldQnSDKr--------QAKQLNWDTVFRFLQKYVYKEMESIks 77   tropical claw...
XP_015196916    8 LLMCCRGLESDKATERKKEADKFKRLIVSPEtve--aldRaSSSra-----akGSKQLTWDGVFGVLRRYVERETEALqt 80   spotted gar
CAF90652        4 LLRYCRELESDKATERKKAAEQFRRLIHSAEvvq--eldHtSGSnfq---tgqGSRQLTWDAVFRFLQRYVQRETESMqs 78   spotted green...
XP_010149124    8 LLICCRRLENEKAVERRKEIENFKRLLHDSEtvl--qldRnSDAk--------QGKQLNWDAVFSVLQKYFQREIKNLql 77   sunbittern
6SL1_A         77 SKKsvkvTA---AAAA-----RLERCPEALRLAVRHGVT----TIR-RKTARAIIDHIVQVLpgpdgaYVMPLLAGYVKV 143  Chaetomium th...
EKC30280      103 ------gKEpqsATARssrekKKQEIGGVFKFVVKQAENrg-pRLRaSQLIRQITEVLRDEF------MLVAYGLDYSSV 169  Pacific oyster
XP_022534729   81 GKAnvsaIT---QANRr---kKMQEISSLIKYFVRCANKrg-pKLKcSDLLAHVVEVMQSSF------SCSAYGEDYSSM 147  Mexican tetra
3_pfamImport   74 ------aKAnvsATTQanrqkKLQEISSLVKYFIRCANKrr-pRLKcQELLKHVMDIMQSSY------SCAAYGTDYSSI 140 
4_pfamImport   71 ------sCSsrsPTAPslaipALRCSSCLIFFFFSIPFLkgapRLKcQELLNFVMDTIKDSY------NSAIYGADCSTI 138 
XP_008116369   78 ------aKPnvsASTQatrqkKMQETSSLAKNFIRCANKra-pRLKcQDLLMYFTNTVNDPS------SYAIYGADCSSI 144  green anole
XP_002934974   78 ------aKPsvsQTTQstrrkKMQDISSVVKDFIRCANKrg-pRLKcTELLLHVSNTVRDPT------TCSAYGADYSSI 144  tropical claw...
XP_015196916   81 ------gKAnvsATTQanrhkKMQEVSSLLKFFIRCANKrg-pRLKcTDLLAHLVGVLRSSF------SCSAYGEDYSSI 147  spotted gar
CAF90652       79 ------gRPsasASVLttrqkKMAEMCSLIKYFIRRANKrg-pRLKcSELLKHVTEVLQSPY------SCAAYGEDYSSL 145  spotted green...
XP_010149124   78 ------mKPnasASTQttrqkKMQEVGSLLKYFIRCANKrg-pRLKcQELLIYVLEIIRDPT------SCAAYGSDCSSI 144  sunbittern
6SL1_A        144 L-YEFLDNPASAENIaalSGEGWE 166  Chaetomium thermophilum var. thermophilum DSM 1495
EKC30280      170 LlKNVLTVRKYCSEI---GEKTWH 190  Pacific oyster
XP_022534729  148 LlKNILSVRKYWCEI---TQQQWH 168  Mexican tetra
3_pfamImport  141 LlKDVLAVRKYWCEI---SQQQWE 161 
4_pfamImport  139 LlKEILSVRKYWCEI---SPPQWA 159 
XP_008116369  145 LlKNILAVRKYWCEI---SSQQWS 165  green anole
XP_002934974  145 LlKDILSVRKYWCEI---TSQQWE 165  tropical clawed frog
XP_015196916  148 LlKDILSVRKYWCEV---TQHQWA 168  spotted gar
CAF90652      146 LlKDILSVRKYWCDM---APQQWH 166  spotted green pufferfish
XP_010149124  145 LlKDILSVRKYWCEI---SQQQWS 165  sunbittern
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