8JG5,6AO5,6BN1


Conserved Protein Domain Family
Mst1_SARAH

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pfam11629: Mst1_SARAH (This model is not part of the current CDD release)
C terminal SARAH domain of Mst1
This family of proteins represents the C terminal SARAH domain of Mst1. SARAH controls apoptosis and cell cycle arrest via the Ras, RASSF, MST pathway. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process.
Statistics
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PSSM-Id: 519811
Aligned: 22 rows
Threshold Bit Score: 69.2381
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8JG5_C       131 YEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 178 human
EFX80950     439 sipLKFLSFEELQQRMSNLDSEMEREITDLRRRYHAKRQPIQDAIDQK 486
1_pfamImport   1 FDFLKFLSFDDLQQRMSNLDSEMEHEIDELRRRYQTKRQPILDAMDQK 48 
XP_015784237 498 FEFLRYLPLDELRKRMANLDYEMENEIEELRRRYAAKRQPILDAIDTK 545
EDO42844      55 FQFLKSASFEELTRRMQSLDFEMEREIEELRIRYQSKRQPILDAMEAK 102
A8XJW8       443 FEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIK 490 Caenorhabditis briggsae
XP_032528762 485 FEFLSFLSSSELEARMAALDAEMEAEIERLHQRYERKRRPILDAITLK 532
XP_003385366 410 kDYLKGLNDDELEEHMTLLDKRMDEELEALRKRYHQKRQPILQAIDAK 457
4_pfamImport   1 FDKLKFLSFDELKEKLSLIDREMERDIEELTNKYNSKRKPILDAITAK 48 
XP_002005626 611 FEFLKFLTYDDLNQRLSNIDHEMELEIEQLNKKYNAKRQPIVDAMNAK 658
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