Conserved Protein Domain Family
Rap1_C

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pfam11626: Rap1_C (This model is not part of the current CDD release)
TRF2-interacting telomeric protein/Rap1 - C terminal domain
This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres. The Rap-1 C-terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain. Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms. Model doesn't capture Sch. pombe as it cuts this sequence into two.
Statistics
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PSSM-Id: 491987
Aligned: 70 rows
Threshold Bit Score: 53.8003
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_036668099  928 TLNSLGFKDPLIGHFIYACSFETLvIVNYITQFLDSlsRKvfasdkKLTfkdkktKNTRkkakdeikaaiegfdwdtelv 1007
XP_002617523  526 EFENIGLQRRFTGHIFKVTGADVRyAHKFLVQFLQGidNHiqtedlLFP------RNQN--------------------- 578 
XP_001484171  438 KLKATGFEPNFTAHIVMATNGDVAkMQEYVHEFLQRmnTQaiadpyELA------QISRn-------------------- 491 
CCE81148      498 AFSDIGITDVFTAHILMCTCADIPrILLFINKFLN-----------MLP------YVKEdeisnal-------------- 546 
Q6BU78        523 SFNEIGINDVFTAHLIMAATGDIVnMQVFIDQFLH-----------LIP------HLLEdklydgl-------------- 571  Debaryomyces ...
XP_001525809  437 KLGQVGLCDNFISHVIYACSAETPvMLNYITAFVKQllKN------KQR------AEGRgggegggeggeaeeirkglvn 504 
XP_007374266  489 ALNKLGLKDPLISHVVYATSADVPlIPTYCQRLFTAlnAArl--epGIP------LYKQlri------------------ 542 
XP_001384938  566 CLEELGFKQALVEHLLYSTCCDKTrLFFLF-RHIYNnlQDnlvsdgHIPvyellqPPDE--------------------- 623 
XP_002489597  482 LYTELGFAHRYTEFLFTSCSGDVIfFRPLVEHFLLTgeWEl--------------ENTR--------------------- 526 
XP_002491351  437 FKNALGVKDYYLTFLLDVTSGNLKlIVQIISNYLEDntQYl----tNFP------------------------------- 481 
XP_036668099 1008 yaylppprnepvG-AWNKSFDAIL----DTSQESKLHKFKSGQEIEQRKKFIA 1055
XP_002617523  579 ------------G-FWIPEYDMSLek-gDLRELQFQSKSS----IAQRRVFLG 613 
XP_001484171  492 ------------G-IWTPETDAMLcs-gNPADIKRLQQTHDHDEIKRRGNFLK 530 
CCE81148      547 ------niegsnG-LWTAEYDRLLld-gSDSGMKTIRQVHDEESIYNRKKFLE 591 
Q6BU78        572 ------qiedtdG-IWTSKLDNYLls-gSKQDMKKLQAIQSPQSIEARRHFLE 616  Debaryomyces hansenii
XP_001525809  505 vykylptgtelhG-IWTDEFDSVLgt-qQESD---LFQYKSGVEIERRFKFLR 552 
XP_007374266  543 ---------vgsGdIWSPKHDQML----GTESEHDLQRPHSLDSIMKRKEFLS 582 
XP_001384938  624 ------------GgFWTKEQDDLLqa-gRDDALEVQNKRQ----IRTRREFLN 659 
XP_002489597  527 ------------G-IWTGRQDEMLra-sNLDDLHKLIDLHGKERVETRRKAIK 565 
XP_002491351  482 ------------G-VFLPRHDIILlaneNKDEIDQLIKYHSLENVEKRRKYLF 521 
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