3K6G


Conserved Protein Domain Family
Rap1_C

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pfam11626: Rap1_C (This model is not part of the current CDD release)
TRF2-interacting telomeric protein/Rap1 - C terminal domain
This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres. The Rap-1 C terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain. Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms. Model doesn't capture Sch. pombe as it cuts this sequence into two.
Statistics
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PSSM-Id: 519808
Aligned: 71 rows
Threshold Bit Score: 48.7928
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K6G_A         22 EKFNLDLSTVTQAFLKNSGELE-ATSAFLASGQR--AD------GYP--------------------------------- 59   human
CCE81148      500 SDIGITDVFTAHILMCTCADIPrILLFINKFLN-----------MLPyvkedeisn------------------------ 544 
Q6BU78        525 NEIGINDVFTAHLIMAATGDIVnMQVFIDQFLH-----------LIPhlledklyd------------------------ 569  Debaryomyces ...
EDK44188      439 GQVGLCDNFISHVIYACSAETPvMLNYITAFVKQllKN------KQRaegrgggegggeggeaeei------rkglvnvy 506 
XP_007374266  491 NKLGLKDPLISHVVYATSADVPlIPTYCQRLFTAlnAArl--epGIPlykqlr--------------------------- 541 
XP_001384938  568 EELGFKQALVEHLLYSTCCDKTrLFFLF-RHIYNnlQDnlvsdgHIPvyellq--------------------------- 619 
XP_002489597  484 TELGFAHRYTEFLFTSCSGDVIfFRPLVEHFLLTgeWElen--------------------------------------- 524 
XP_002491351  439 NALGVKDYYLTFLLDVTSGNLKlIVQIISNYLEDntQYl----tNFPg-------------------------------- 482 
XP_036668099  930 NSLGFKDPLIGHFIYACSFETLvIVNYITQFLDSlsRKvfasdkKLTfkdkktkntrkkakdeikaaiegfdwdtelvya 1009
EEQ38841      528 ENIGLQRRFTGHIFKVTGADVRyAHKFLVQFLQGidNHiqtedlLFPrnq------------------------------ 577  Clavispora lu...
3K6G_A         60 -----------IWSRQDDIDLqk-dDEDTREALVKKFGAQNVARRIEF 95   human
CCE81148      545 --alniegsngLWTAEYDRLLld-gSDSGMKTIRQVHDEESIYNRKKF 589 
Q6BU78        570 --glqiedtdgIWTSKLDNYLls-gSKQDMKKLQAIQSPQSIEARRHF 614  Debaryomyces hansenii
EDK44188      507 kylptgtelhgIWTDEFDSVLgt-qQESD---LFQYKSGVEIERRFKF 550 
XP_007374266  542 -----ivgsgdIWSPKHDQML----GTESEHDLQRPHSLDSIMKRKEF 580 
XP_001384938  620 -----ppdeggFWTKEQDDLLqa-gRDDALEVQNKRQ----IRTRREF 657 
XP_002489597  525 --------trgIWTGRQDEMLra-sNLDDLHKLIDLHGKERVETRRKA 563 
XP_002491351  483 -----------VFLPRHDIILlaneNKDEIDQLIKYHSLENVEKRRKY 519 
XP_036668099 1010 ylppprnepvgAWNKSFDAIL----DTSQESKLHKFKSGQEIEQRKKF 1053
EEQ38841      578 ---------ngFWIPEYDMSLek-gDLRELQFQSKSS----IAQRRVF 611  Clavispora lusitaniae ATCC 42720
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