2YRB


Conserved Protein Domain Family
C2-C2_1
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pfam11618: C2-C2_1 (This model is not part of the current CDD release)
First C2 domain of RPGR-interacting protein 1
This domain is the first, more N-terminal, C2 domain on X-linked retinitis pigmentosa GTPase regulator-interacting proteins, or RPGR-interacting proteins.
Links
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Statistics
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PSSM-Id: 519804
Aligned: 37 rows
Threshold Bit Score: 114.649
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YRB_A         10 TIHLERGENLFEIHINKVT-FSSEVLQASGDKEP---------VTFCTYAFYDFELQTTPVVRGLHPEY-NFTSQYLVHV 78   human
XP_003063603  159 MDDLALGENIFELRLLGVD-IEKDAV---DEANP---------ATFMTVDFFEHETQATAVQNGLNVTV-DHTLQYIVKA 224 
XP_001465822  716 IGEVGENENIFELYLGQLVaAEAPEGIEVPEMFS---------TVFCSADFLVHETVTTGTVRGFNGFF-EVTASFCVSM 785 
XP_001565207  506 IGEVGENENIFELFLGQLVaAEVPEGIEVPEMFS---------TMFCSADFLVHETITTGTVRGFNGFF-EVTASFRVSM 575 
Q57YZ5        629 LCEVEGNETVFELFVGQILsTETPAGVELRNTFP---------PVFCSIDFLLHETVTTPVVAGLNAFL-DTSVSFCVAM 698  Trypanosoma b...
XP_002952370 5465 FSEIGEDQNIFELHITEAQ-VNEEALGKDP-------------SVFFTFDFFMHETQATPIMASNSPSF-NTIIQYVVDN 5529
XP_001031938  621 EEELGPGENFFDIFIGSVD-LDENICQRQSDTILnmq----eiMTFFTVDFYNHDTQHTTIVDGKKNSY-NFQATFKVKV 694 
A0DEF1        574 DEMLSPGENFFDLWVGKGE-YQPAELVSSYKTSTqlnldlgslLTFVTIDFYDHETQHTSVSEGTSCFY-NLQISFKVDA 651  Paramecium te...
XP_004035345  108 SDMKENGCNYFDFWIGLCQiYQGNLFAITNGKISene----eiLVFSTVDFYDHDIQTTPISQAKNQTYfNFQCSYKITT 183 
XP_004035682  183 EEELGIGENIFDLYIGKIN-MDENEILRQNENINdlq----cfLSFFTIDFYNHDTQHSSVVEGLRNNY-EFQASFKVKV 256 

2YRB_A         79 NDLFLQYIQKNTITLEVHQAY-STEYETIAACQLKFHEIL----EK-------S-GRIFCTASLIGT-KGDI--PNFGTV 142  human
XP_003063603  225 DAFFLEYLDTKHLPVELNKSL-GMDFATLGVARVNLKRVL----DDaraghdpK-QPPVHFCDVVGR-SGE----IIARL 293 
XP_001465822  786 DALLFYYLHTRQLLIQLHRVRnAEEAAAMTLAAAAGAGDEe------------T-HLSVTDAVDTGTtHSAHggSSSGST 852 
XP_001565207  576 DALLFYYFHTRQLLLQLHRVRdADEAAAMTVAETTGAGAEd------------A-HFSANAVAETGTtHSA----HSGST 638 
Q57YZ5        699 DALLLCYLQTRQLLLQLHCVRsQEELGETMVDNDETGKLC--------------------------IgERLYttVAEGSV 752  Trypanosoma b...
XP_002952370 5530 DPFLLEYMDTHVLVLDLCRAR-GYDYDVLGMARLPLRQVL----EDleigaalGyNRAYHYADVFGA-DGK----RLGRV 5599
XP_001031938  695 DDFFITFLKEKYLKLELYHVQ-QQNAILFGTANVPLGQLIsentSPs-----iS-AVIEQTVKVRAt-RGMSqdQFIACL 766 
A0DEF1        652 DANFIQYLESNYLKLELYVSQ-GSEPTKIGSGLIQLKDLVyenkNDt-----iS-KVISGSLTFHG-----InnQMIGIV 719  Paramecium te...
XP_004035345  184 KDDFLLYLSTGSIKIELYAAV-GKDALLLGSVEVPLLYLFqnnrQEc-----iS-AVLNQKCQLNF-----Ae-TIIGQI 250 
XP_004035682  257 DEFYITYLKERFIKLELYNVQ-QQNAILIGSANISLFQIIsentKPn-----iS-AVIEQSVKIRGLkQGVLqnKFVGCV 329 

2YRB_A        143 EYWFRLRVS 151  human
XP_003063603  294 RYAAFMRKS 302 
XP_001465822  853 HPSLRMAEH 861 
XP_001565207  639 DPSLRIAEH 647 
Q57YZ5        753 SLSALVADP 761  Trypanosoma brucei
XP_002952370 5600 RYGYCFRRP 5608
XP_001031938  767 NIKYRMRYP 775 
A0DEF1        720 EFKARMRYP 728  Paramecium tetraurelia
XP_004035345  251 EIKARLRYP 259 
XP_004035682  330 DVKFRMRFP 338
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