7TD5,5U62


Conserved Protein Domain Family
EZH2_WD-Binding

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pfam11616: EZH2_WD-Binding (This model is not part of the current CDD release)
WD repeat binding protein EZH2
This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.
Statistics
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PSSM-Id: 519802
Aligned: 7 rows
Threshold Bit Score: 43.3296
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7TD5_A        39 KALYVANFAKVQEKTQILNEEWKKLRVQPV 68  human
XP_003222404  44 KALFASNYAKVQEKLDILNDDWKNLRVQPI 73 
4_pfamImport   1 ESQFMANRSKIKEKTELLNDEWSNLRIQPI 30 
XP_005796763  61 KSLFMSNRQKIELQTNLLNTEWSKLRIQAI 90 
XP_014342733  41 KSLFTANRNKVKERTEVLNEDWKKLRVQPT 70 
XP_064409361  39 KSMFNSNRQKIQEKTEILNQEWKQRRIQPV 68  coelacanth
5U62_D         1 KSMFSSNRQKILERTEILNQEWKQRRIQPV 30  human
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