Conserved Protein Domain Family
EZH2_WD-Binding

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pfam11616: EZH2_WD-Binding 
WD repeat binding protein EZH2
This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.
Statistics
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PSSM-Id: 402972
View PSSM: pfam11616
Aligned: 9 rows
Threshold Bit Score: 56.3095
Threshold Setting Gi: 123893589
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003222404  44 KALFASNYAKVQEKLDILNDDWKNLRVQP 72  green anole
XP_014342734  54 KSLFTANRNKVKERTEVLNEDWKKLRVQP 82  coelacanth
CAF90425      36 KSMFSTNRQKIMERTDILNQEWKTRRIQP 64  spotted green pufferfish
XP_015217358 146 qsqFMANRSKIKEKTELLNDEWSNLRIQP 174 spotted gar
Q29RB7        45 KALFQSNRRKIEVGTELLNEEWSKLRIQS 73  zebrafish
XP_005796763  61 KSLFMSNRQKIELQTNLLNTEWSKLRIQA 89  southern platyfish
XP_021068395  42 KALYVANFAKVQEKTQILNEEWKKLRVQP 70  shrew mouse
XP_017953284  55 rmfYVENLTKAQERAHLLNEDWKKLRVQP 83  tropical clawed frog
GCF59166      56 KSMFNSNRQKIQDRTEILNQEWKQRRIQP 84  Paroedura picta
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