Conserved Protein Domain Family
Vps36_ESCRT-II

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pfam11605: Vps36_ESCRT-II 
Vacuolar protein sorting protein 36 Vps36
Vps36 is a subunit of ESCRT-II, a protein involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes.
Statistics
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PSSM-Id: 402964
View PSSM: pfam11605
Aligned: 19 rows
Threshold Bit Score: 93.9123
Threshold Setting Gi: 74855186
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VU87         2 NRFAYVEARLSPNESFVSRDNRVKIYDGDQ--KT-DFEDGEVVLTTHRLFWGRPGEIARaAVTLCLPLSYVIsvseETTA 78  fruit fly
EDK42855      11 KINRSNRPILDDLEHSVYVKDNVGLYQGKA--KItNHQNGRLYLTNKRIIYFDNDDCKNqSAAVDIRHLTSA----ELID 84  Lodderomyces el...
O43038         6 ETTPSNLPVLDPSEEILLVQDQVGLYFGDE--KSfRHNNGTLYLTKKHIFYVDSVDPKKnSLKIKISDIRDV----QHTS 79  Schizosaccharom...
Q4DRE4         5 EWQT-GEGVMGDEEVVLHSQNGVAIYEGEN--RT-HWKDGKLTVTTHHIIF-RTISGEShVLRLPLETVYSSgk-sAYSK 78  Trypanosoma cruzi
Q4QDE7         5 EWKTDGAG-LEADEVCITVQHGVTLYDKNE--KT-QRQNGKLSLTTHHLRYNDEADISTv-LQLPLELVRRSgqapSISS 79  Leishmania major
XP_001564201   5 KLNTDGTG-LEVDEVCILSQHGVTLYNGDE--KT-HRRNGKLALTTHQLRYNDEADVSTv-LQLPLELVRRSgrapSLSS 79  Leishmania braz...
Q9FF81        18 EVTTSGRPVLRRNEVECFLLSSIDIDSEDDppRFtALRSGNLILTTHRLIWIPSQSNESvPSSIPLSAVTHIyshkKSIK 97  thale cress
Q54T18         8 TRVINGEPELIQNESIIYKVDNVSIYDGDQ--KT-QYSNGTVMLSTHRVIWV------NkDIGLGLLHQLILnieaLTTG 78  Dictyostelium d...
Q5TPR5         2 NRFEYCQARLFENESFVAKDRNIKLYDGDE--KT-NYEDGEVVLTSHRLLWGRNGEIARgGSCLALKLKYVLsvdeEEAS 78  Anopheles gambi...
Q6BSQ4        12 SVNRSNRPILQEGEHNLYVRDNIGLYQGKL--KIvNRQNGRVYLTNKRIIYLDNEDVKK-SMAIELKNVSSG----EVIE 84  Debaryomyces ha...
Q9VU87        79 SNFfGRKTRIIMHLHP 94  fruit fly
EDK42855      85 GFL-RSSPKVKLFIKT 99  Lodderomyces elongisporus NRRL YB-4239
O43038        80 RYF-RSSPKIRLSLRH 94  Schizosaccharomyces pombe 972h-
Q4DRE4        79 GRLgFSHAKIIVPLPG 94  Trypanosoma cruzi
Q4QDE7        80 GFGpFSSAKIIVPLPK 95  Leishmania major
XP_001564201  80 GFGpFSSPKIVVPLPQ 95  Leishmania braziliensis MHOM/BR/75/M2904
Q9FF81        98 SMF--HSPRIRFQADP 111 thale cress
Q54T18        79 LMGiGSSPKILITLTK 94  Dictyostelium discoideum
Q5TPR5        79 SMLfGRKKRIILRLGS 94  Anopheles gambiae str. PEST
Q6BSQ4        85 RFL-RSSPKVKLYLKE 99  Debaryomyces hansenii
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