1ZBX


Conserved Protein Domain Family
Sir1
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pfam11603: Sir1 (This model is not part of the current CDD release)
Sir1, ORC-binding domain
This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Links
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Statistics
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PSSM-Id: 519795
Aligned: 35 rows
Threshold Bit Score: 89.2116
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1ZBX_B         10 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKD-HQRAMIDQMNLVKWNDFKK-YQDPIPLKAKTLFKFCKQIKKKFL 87   brewer's yeast
2_pfamImport    1 AISERYTVVDKYVVDTQERKL--IDPEVLRRSGTD-EEKDQLSNYTLLDWNVLKL-SKYPYGSDAEELFDILNAPSEDFY 76  
XP_003671428  296 KISDSLMVTGGFLVDIIEKKIINPNEQDYLRNLTD-EEKEYIEECDLVDWNILKL-TKHPYAVDSPQLFDTLNANNEDFY 373 
XP_003670063  436 IPSKRYIIVDRFLIDIVGKRVVDPMDHELLKEMTY-REREITFGKGLYDWNLLLF-NEDPIPTFSTILFNLVEYSSSQIL 513 
XP_003958924    4 IISERYCVIEGWIVDQVDR--IIVPKSKIVKNLVP-KKLELLNRQFLIDFKNVDLsQSVIYEYTSQELHDLIDKEFYEFS 80  
XP_022463372    4 QITDDIVVIDRWIVSIPDRKV--VSSFAAKRQLSQ-ANYRKLVAIEPVDLTRF---TTTFHTVDSPELFQHIDLHPHEFA 77  
XP_003959754    6 YITNNIAIIDGWIVDTSKN--FVLTMYNCKQQLDS-YVFTKLNQHVLQNYKSLANpKNQIFAVESEMLFQHAKLEAHRFY 82  
4_pfamImport    1 KFNDRYAIINGWIVDLVDSKI-INPYSRSDRFTIGaSLMKEIWKWHPRNLNDYYNpNCFLYCEDSEELLKYLPTKQYSFH 79  
6_pfamImport    1 SLNDQYSIIDGWLVDFINKCVVDPLHQSIKSSFRD-GNYNELLKHKFVHFRDLEDaKTILIGIDSKQLFEHVQQRMYIFV 79  
8_pfamImport    1 KLNSRYVAIDGWLVDIDQKRI--INPEDIADDLPN-EDYFKLSQLHLKNWEEVSDePQLFISTKSQLLVEKIRWRLQDFV 77  

1ZBX_B         88 RGADFKLHTLP-TeanLKYEPERMTVLCSCVPILLDDQTVQYLY 130  brewer's yeast
2_pfamImport   77 EDIKGNISTNReM---LDQKGKIKTVPHRSVSIYFEEFGWKHIY 117 
XP_003671428  374 EDKNGDLWIVPp----TEYKGALTPRKYRSIPLHFKSFGWRHIY 413 
XP_003670063  514 WDRYGDIHLQPt----MINANGSNVQIRRTVAIDLKENGIRYIY 553 
XP_003958924   81 ELLDGRIINKDgRiyqRSKTKIKRTFTKRCHRVSIHGRQYVYLL 124 
XP_022463372   78 VLPNGDAVPRSsVayrRADKSKCNLFTRMSHRVSTGGRRVVYLV 121 
XP_003959754   83 KLRDHSVTLRKsRraeRTKKIVEQTIDVKCHRLALGRRNYIYLA 126 
4_pfamImport   80 KLKSGSILPNTmHr--QSPRNVVEVLSYPCYQLSFGKNRTIFIH 121 
6_pfamImport   80 KTVDGELKLKNsV---IANQSIVNEFTKKCHKITLENGKEVYLF 120 
8_pfamImport   78 ELLDGRIVPKStQ---IPTTEVLDEFSRKCHKLTLSNKISKYLF 118
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