1Z1A


Conserved Protein Domain Family
Sir1

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pfam11603: Sir1 (This model is not part of the current CDD release)
Regulatory protein Sir1
Sir1p interacts with the BAH domain of the Orc1p subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1p are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing.
Statistics
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PSSM-Id: 491974
Aligned: 34 rows
Threshold Bit Score: 88.8331
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Z1A_B         20 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKD-HQRAXIDQXNLVKWNDFKK-YQDPIPLKAKTLFKFCKQIKKKFL 97   brewer's yeast
XP_003674470  298 AISERYTVVDKYVVDTQERKL--IDPEVLRRSGTD-EEKDQLSNYTLLDWNVLKL-SKYPYGSDAEELFDILNAPSEDFY 373 
XP_003671428  296 KISDSLMVTGGFLVDIIEKKIINPNEQDYLRNLTD-EEKEYIEECDLVDWNILKL-TKHPYAVDSPQLFDTLNANNEDFY 373 
XP_003670063  436 IPSKRYIIVDRFLIDIVGKRVVDPMDHELLKEMTY-REREITFGKGLYDWNLLLF-NEDPIPTFSTILFNLVEYSSSQIL 513 
XP_003958924    4 IISERYCVIEGWIVDQVDR--IIVPKSKIVKNLVP-KKLELLNRQFLIDFKNVDLsQSVIYEYTSQELHDLIDKEFYEFS 80  
XP_022463372    4 QITDDIVVIDRWIVSIPDRKV--VSSFAAKRQLSQ-ANYRKLVAIEPVDLTRF---TTTFHTVDSPELFQHIDLHPHEFA 77  
XP_003959754    6 YITNNIAIIDGWIVDTSKN--FVLTMYNCKQQLDS-YVFTKLNQHVLQNYKSLANpKNQIFAVESEMLFQHAKLEAHRFY 82  
2_pfamImport    1 KFNDRYAIINGWIVDLVDSKI-INPYSRSDRFTIGaSLMKEIWKWHPRNLNDYYNpNCFLYCEDSEELLKYLPTKQYSFH 79  
3_pfamImport    1 SLNDQYSIIDGWLVDFINKCVVDPLHQSIKSSFRD-GNYNELLKHKFVHFRDLEDaKTILIGIDSKQLFEHVQQRMYIFV 79  
5_pfamImport    1 KLNSRYVAIDGWLVDIDQKRI--INPEDIADDLPN-EDYFKLSQLHLKNWEEVSDePQLFISTKSQLLVEKIRWRLQDFV 77  
1Z1A_B         98 RGADFKLHTLPtEa-nLKYEPERXTVLASCVPILLDDQTVQYLY 140  brewer's yeast
XP_003674470  374 EDIKGNISTNReM---LDQKGKIKTVPHRSVSIYFEEFGWKHIY 414 
XP_003671428  374 EDKNGDLWIVPp----TEYKGALTPRKYRSIPLHFKSFGWRHIY 413 
XP_003670063  514 WDRYGDIHLQPt----MINANGSNVQIRRTVAIDLKENGIRYIY 553 
XP_003958924   81 ELLDGRIINKDgRiyqRSKTKIKRTFTKRCHRVSIHGRQYVYLL 124 
XP_022463372   78 VLPNGDAVPRSsVayrRADKSKCNLFTRMSHRVSTGGRRVVYLV 121 
XP_003959754   83 KLRDHSVTLRKsRraeRTKKIVEQTIDVKCHRLALGRRNYIYLA 126 
2_pfamImport   80 KLKSGSILPNTmHr--QSPRNVVEVLSYPCYQLSFGKNRTIFIH 121 
3_pfamImport   80 KTVDGELKLKNsV---IANQSIVNEFTKKCHKITLENGKEVYLF 120 
5_pfamImport   78 ELLDGRIVPKStQ---IPTTEVLDEFSRKCHKLTLSNKISKYLF 118 
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