Conserved Protein Domain Family
Sir1

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pfam11603: Sir1 
Regulatory protein Sir1
Sir1p interacts with the BAH domain of the Orc1p subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1p are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing.
Statistics
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PSSM-Id: 402962
View PSSM: pfam11603
Aligned: 26 rows
Threshold Bit Score: 97.6968
Threshold Setting Gi: 403217599
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD27200       10 NVSDRISIV-DGFFVMVETSennvtKKVIKNYETSTWKL--TNKEITMVSNYKdrLFDITSYHTeYPNSELIPHNSHLLF 86   Naumovozyma d...
P21691          3 QINSRLAVI-DGWLVDTVKR------KPINFRSPEVRLLlpNDDDYKKLSQQN--LVDWTRLKK-DSNSVLVGVKSMELF 72   Saccharomyces...
XP_003959754    6 YITNNIAII-DGWIVDTSKN------FVLTMYNCKQQL---DSYVFTKLNQHV--LQNYKSLAN--PKNQIFAVESEMLF 71   Kazachstania ...
XP_003678548    3 SLNDQYSII-DGWLVDFINK------CVVDPLHQSIKSSf-RDGNYNELLKHK--FVHFRDLED--AKTILIGIDSKQLF 70   Naumovozyma c...
CCD24820        3 MLNTRYTFI-NGWIVDLENG------KIINPDLKTYKPL------KKLLGDLQ--YWNWDEYFKqSDHCQLYCDDSSVLF 67   Naumovozyma d...
XP_003673281 1350 MISDRFFVV-NGFIVDTSCRvt--gKDIIRPKDFVLERC--SEFEKALLNKQY--LFDVDSFQF-EDTADIFPIDAPALF 1421 Naumovozyma c...
XP_003671428  296 KISDSLMVT-GGFLVDIIEK------KIINPNEQDYLRNl-TDEEKEYIEECD--LVDWNILKL---TKHPYAVDSPQLF 362  Naumovozyma d...
XP_003672439  435 YITLRFLLInDKFIIDLAEN------KLINPKSKTFLESi-PEYVADALGQFD--FFDWSIFNF---SNEPFPIYCSELF 502  Naumovozyma d...
XP_002497885  283 NINENYGIV-DRFVINLPTK------CIVDPETIEW-----SLEEREFLQSKN--LMDWNTLKL---SKGPIPIRNTVLF 345  Zygosaccharom...
CCC70498      432 KPSKRYIIV-DRFIVDLTER------RIINPNGEEISDIl-TRWELSVLAKRD--IFDWDVFLF---DQSLVPVFSSMLF 498  Naumovozyma c...
CCD27200       87 ENCTTIEKKFYPTNEGFKSVNSRTS--------KKDISESQTYSVIPIRLKGLPNKYL-Y 137  Naumovozyma dairenensis CBS 421
P21691         73 KHIKLVLREFFLLEDGRIILKRIRSk------lRYKVVKKLTCKCCRLYLPKWGTVYI-H 125  Saccharomyces cerevisiae S288C
XP_003959754   72 QHAKLEAHRFYKLRDHSVTLRKSRRae----rtKKIVEQTIDVKCHRLALGRRNYIYL-A 126  Kazachstania africana CBS 2517
XP_003678548   71 EHVQQRMYIFVKTVDGELKLKNSVIa-------NQSIVNEFTKKCHKITLENGKEVYLfY 123  Naumovozyma castellii CBS 4309
CCD24820       68 GLIEMEDYNFLRMKDHTITREKESIwnrnrnrnRNRIVDIIEVQAHKISISNHKVVYL-H 126  Naumovozyma dairenensis CBS 421
XP_003673281 1422 FQCTTSVERFIYTECGFLHWNPHGKy-------KPKRGELETHRVIPVSLGDI-TKYV-R 1472 Naumovozyma castellii CBS 4309
XP_003671428  363 DTLNANNEDFYEDKNGDLWIVPPTE--------YKGALTPRKYRSIPLHFKSFGWRHIye 414  Naumovozyma dairenensis CBS 421
XP_003672439  503 EELHMEEREFILDDRGVLHVNNSGY-----------SGMIVKVPCAAIELKDKSVIYI-Y 550  Naumovozyma dairenensis CBS 421
XP_002497885  346 EHVNWETKRFLKDFHGHITVSDDSNv-------SSPDSNSIITRCILINLKGFGIRYL-Y 397  Zygosaccharomyces rouxii
CCC70498      499 NLVQCQDILLTRDEKMRVHIQPDFE----------TGQNFDKRRCIILDLKEHGLRYL-Y 547  Naumovozyma castellii CBS 4309
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