Conserved Protein Domain Family
Med13_N

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pfam11597: Med13_N (This model is not part of the current CDD release)
Mediator complex subunit 13 N-terminal
Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood.
Statistics
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PSSM-Id: 519791
Aligned: 80 rows
Threshold Bit Score: 90.9815
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013342529     1 MDFLKSC--WTNLQAVDGYSHIDYLIY--------QHQDAIQGQKSEWDdqe------qrDELLLslRQKKVLVQTAVlq 64  
1_pfamImport     1 MSDSSTS--IEASYE-GGLHHVSWFQF--------LPNESDLNAL---------------PDKRLk-DAATFLVLSSHlq 53  
XP_024356013    10 GRSLEDS--HTNIFALTDLSGIHYRVY--------RPKDDRNYSVY--------------DDPLLs-AYNNCLREN---- 60  
KZO93748        56 LTLNSSTplALSKIEWPKDACVKWKVLrlkedlelVDKEKEELMEGARRkiv-----gewKEGILd-GLVGYLRRDPNn- 128 
XP_003025901    33 ISYADEL--LTSAFDLTRTPCLVWCRY--------SSYADAIDGAEAVEra--------rLAIPEs-NAGKGLLESDLts 93  
2_pfamImport     1 LSSSNPI--LASVIPLPHDTLIAYSSF--------SSTGLDTSSIELARrqil----akcASDLLg-SLLTSVQVARE-- 63  
18_pfamImport    1 VSLSEQV--LSSVVSLPDNPVIAYTTF--------TTQSTTIRPYEALElarrllvnrnkGLPLLd-SLLPCVNVSQD-- 67  
XP_040770687    25 VSLASPI--LGSIISLPDNPLIAYSVFtsa---ssQPLRDPLNLIELARrkil---sqnaKRHFLd-SLLPSVHITKD-- 93  
XP_007392085    23 ISLSSPI--LASAIDLPPNPLISCSVFia----trAPTPTEQLTAIENArrriv--adytPLPMAq-SLLPSVHVTKD-- 91  
21_pfamImport    1 ISLDSPI--LASAIDLHEDPLIVYSVYt------aDPSVDASEQLSIIDsgrrsivqlnaKRSILg-SLLPSAHVTRD-- 69  
XP_013342529    65 ----kKVCVFGGFI------TADEHMKE-------------LGWQVHQRGRLEAAVMTRAN------------------- 102 
1_pfamImport    54 lqkegFLSTWTNSFvg---pWDPSQGLHnpdek----iklwLFLPGRHSSVETAQAAVSRLrvv---------------- 110 
XP_024356013    61 -----LMCAWVRRKrastepHKPDIFSNfsk-------elwVFWYGSDDPCTRSRDRLISSdlee--------------- 113 
KZO93748       129 ----sAPELWIFEV------GDAREGGAl------------SQFCIPELQCGSDGHFHPSW------------------- 167 
XP_003025901    94 vragsRSRIYVFRLgakealREMKTAMAk------------LSFEGLEACIALDEIYGPTN------------------- 142 
2_pfamImport    64 -----RSTLHVFAFgstlrtTESHAALN--------------ALSFPGLSTSQSSSFTPHDlypcs-------------- 110 
18_pfamImport   68 -----LSALQVFAItsr-dhVSAKLAAI-------------KDISFDGLTVSGESSFTPHDlyp---------------- 112 
XP_040770687    94 -----VSALYVFAFgstdrtSEAHAALN--------------ALQFDGLASTGPTNFTPSAiyp---------------- 138 
XP_007392085    92 -----RVSLYLFAFgstmdaSAAQMPLSlgtrktrhllqlkMLLCESGAVLYRQSFTYISCvrvaerngpctmggpglla 166 
21_pfamImport   70 -----QSSLYVFAFgstagvSEGQAALE--------------ALQLHCLTSQETSFFTPSSlyp---------------- 114 
XP_013342529   103 -----------NDAKIVMQNQQ-------------------------------------------IFSMFLIAVEASLSM 128 
1_pfamImport   111 --------asgLWVAPGDSEE--------------------------------------------VAAALSQALRNCIER 138 
XP_024356013   114 -------sssgNWGNGLTYE---------------------------------------------TRCVLFKALHNVIER 141 
KZO93748       168 -----------LYPCPDCVGKPhpcpkcntnadaip----------------tpgmlvprqdfrrPLWMYLTSLRDKLLD 220 
XP_003025901   143 -----------SSTARIPSKTTr-----------------------------------------tILSHFFEAIRTRFVD 170 
2_pfamImport   111 -------tecsVIPIPCPTCLNpsstpkssssvsss---------------tsaacrlprhplraIYSQFLEAIRNKLIN 168 
18_pfamImport  113 ---------csLACSDDQSPCPsclkrdpsslsqstl--------------sspacllprkplrsAYYHFLDAVRKRLID 169 
XP_040770687   139 ---------csAKCADQLTPCTeclthvprnlssas----------------ssailfprkplrlPLHYLLNAIRLRLID 193 
XP_007392085   167 hakrciqkfdtYSFTPDGIYPCslscatqrvpcavciqqreassfatpssqasptcslprkplrlPLVQFIQAVRDRIID 246 
21_pfamImport  115 ---------csAACSELPSPCSncpdivsadcttas----------------ssgppllrkplrlPFFQFLQAVRDRLVG 169 
XP_013342529   129 SL-------SSACGAVR--VGHLAW------------------IVPTEGDYHLLSLRVQ-MTAQGTLA-----LLPHA-T 174 
1_pfamImport   139 AL--------NGLSYLR--FGDVFSkyq------------psqSEESFRKGHPTIEFIFaATEEAIFIha---lvSAK-H 192 
XP_024356013   142 YL--------LKKGYVR--LGKWFLq----------------pCNSQSIRDKTQYSINFsFFLHGESTvc--aSLDIR-R 192 
KZO93748       221 RL-------ARLRDGCR--MGDGVVyast-----------driARELDNGWQQDESSLYlLHAHIQLSlqtrcLF----I 276 
XP_003025901   171 DVvrq--atNVKRDVQR--FKTGFLfgatvpmarstkeqqsteDNWSAGWDAYASARPL-TFVHLDIQldarlRL----L 241 
2_pfamImport   169 DLsestkktPESPPVRR--FKSGFLlgps----------nrgtYEWGEGWEHHARSRPL-IYCSLQLHl----SPTQI-L 230 
18_pfamImport  170 DIsea--srKTPHGRCArgFQDGFLlspp-----------rsyFDWGVDWQHHVNTRPF-IHCHLEIHl----ATSRL-E 230 
XP_040770687   194 DIatesmlkPRSRRATR--LRDGFLlgpsp---------saseSEWGAGWEHRARGRPL-IHAHLDVQl----AQTRI-V 256 
XP_007392085   247 DI-------VRSSSETSerWTGRLQggfllsp-----lspaddGEWGAEWEHYGRSRPF-VHCELQISl----SQTRL-V 308 
21_pfamImport  170 DIcenskekANGRTAVK--LKDGFLlsss-----------pasSEWGAGWEHHARTRPL-IYCHLQLHlshapPSSARlI 235 
XP_013342529   175 NTGLSTASG------------------------TDGANIILAPSGTLATVAHSlst-----tsnDDAPPLQARREARmRl 225 
1_pfamImport   193 IHSLSGGDMekgfkh------------ssssssSLRLPVIVSPHGMRGRLTGYcptdlvkqvyfRTSNGCVGLPHVSqGs 260 
XP_024356013   193 FPKFKSLTSrilsf---------------ceksGGRFNVVLAPYGITAHLVVP-----------SHAYTNDGFVD----- 241 
KZO93748       277 HPSVRSSSLisfpvd-------------rqmqpSPLTAVTLLPYGHPAYYLSYsh--------tKVAPTTLDPYLQG--- 332 
XP_003025901   242 INPIFRPTShrplplptpfhrhsrtshashsslSAGIPITLLPHGTAAHFLAEytpt---dsraLDREFEKGFRGTGvL- 317 
2_pfamImport   231 IHPILRPTDllplpf-------------hhpttPTGTPIALIPYGTPAYYLTSytgptsglvnqFEQSLHGLGVGG--W- 294 
18_pfamImport  231 IHPIIRPTHfspls--------------vhlplAPGTPIALMPYSTPAFFLATytgptsalsaqFEQSLAGLGAGD--Wk 294 
XP_040770687   257 IHPILRPTFylplq--------------cplsvPSGTPITILPHGVPAYYLNTytgptsalttqFEEALLGFGAGD---- 318 
XP_007392085   309 ILPILRTTQylplt--------------tslslPTGTPIVLLPHGTPAFYLNTysgalgnlthqFEDALFGLGVGNWk-- 372 
21_pfamImport  236 IHPVLRPSYylply--------------nmlplPSGTPMALLPYGVPAFYLSTysgpstalttqFEDSLVGLGAGD--Wk 299 
XP_013342529   226 s----rRAKHDNWKASAATKLQ-------RSSlphddSWLRVSVPs------------------STSQDQLECLWPGPLC 276 
1_pfamImport   261 gcqlngQNCYVEVTMGCPRSGS-------DKAshinsNSLRNLHKhnvsespsvgggdpkgspdNMSAYEKTFIYPAEAV 333 
XP_024356013   242 -------KELESWKRFFPMRSPgenyshpNSSahrnsFYLDFLTPnkss------------paqQQPQGSRSDVFSKRSS 302 
KZO93748       333 -------LGASAWRLDD------------RDA-----GWVECWILtps--------------tvPNTDSGFSIIWPAYLV 374 
XP_003025901   318 ------FHTSISSSPQDHNAHI--------PStpyiiGYLAIENR-------------------HGEPKGLTFVYPRQLC 364 
2_pfamImport   295 ------TERCATNQDTGMPSAP-------SRTptfvvAWINIQNK-------------------QGEDKGMTIIYPTHLC 342 
18_pfamImport  295 t----mTSPYSHSVSNGKHRSAdp---saRKYpmyiiAWLAVENK-------------------QGEDKGMNIIWPTELC 348 
XP_040770687   319 ------WKGALDMKMQQNGVGAsq----vDRKvmyviAWLAVQNK-------------------QGEDKGTPIIWPIRLC 369 
XP_007392085   373 -------SAPVNESTNSPCYLI---------------AWVSVQNK-------------------QGEEKGLPVIWPTTLS 411 
21_pfamImport  300 r----pCAISEQRLKPEHARSGc-----qNSSptfviAWLAVQNK-------------------QGEEKGIPLIWPARLC 351 
XP_013342529   277 -LEIP 280 
1_pfamImport   334 lVPVL 338 
XP_024356013   303 ---AG 304 
KZO93748       375 -AQDV 378 
XP_003025901   365 lLSTD 369 
2_pfamImport   343 lTFHP 347 
18_pfamImport  349 lSYLP 353 
XP_040770687   370 lAYHP 374 
XP_007392085   412 vLPDG 416 
21_pfamImport  352 iTYHP 356 
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