Conserved Protein Domain Family
Med13_N

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pfam11597: Med13_N 
Mediator complex subunit 13 N-terminal
Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood.
Statistics
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PSSM-Id: 402956
View PSSM: pfam11597
Aligned: 84 rows
Threshold Bit Score: 89.4554
Threshold Setting Gi: 1516602261
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX07170        1 MDSPSNA--LTNVLKIDNLSRVPYATY----TLAVSDDDFIGLDEDRQcdi--lrdAERTLR-AEGVPVLSDLE------ 65   Pyronema omph...
KDO54455        1 MSDSSTS--IEASYE-GGLHHVSWFQF----LPNESDLNAL---------------PDKRLK-DAATFLVLSSHlqlqke 57   sweet orange
XP_011681830   10 GASLEDC--YTNLFAVADLSGIRWRHY----SWIRPTEPVAPL-------------EDPVLQ-SYAKCIKAN-------- 61   purple sea ur...
EUB64817       10 GRSLEDS--HTNIFALTDLSGIHYRVY----RPKDDRNYSVY--------------DDPLLS-AYNNCLREN-------- 60   Echinococcus ...
EKM59526       23 ISLSSPI--LASAIDLPPNPLISCSVFiatrAPTPTEQLTAIENARRRiva--dytPLPMAQ-SLLPSVHVTKD------ 91   Phanerochaete...
EMD41184       25 ISLDSPI--LASAIDLHEDPLIVYSVYt--aDPSVDASEQLSIIDSGRrsivqlnaKRSILG-SLLPSAHVTRD------ 93   Gelatoporia s...
XP_003025901   33 ISYADEL--LTSAFDLTRTPCLVWCRY----SSYADAIDGAEAVERAR--------LAIPES-NAGKGLLESDLtsvrag 97   Schizophyllum...
KDQ65114        8 LSSSNPI--LASVIPLPHDTLIAYSSF----SSTGLDTSSIELARRQIla----kcASDLLG-SLLTSVQVARE------ 70   Jaapia argill...
KZT66995       24 PHISPESsvLASAIALPQYPLIAYAVFsggpSTRADNLNCIEHARRKVlm----qnSGPDILdSLIPAVHISMD------ 93   Daedalea quer...
XP_024510859   25 DVTLEDC--HTNVLPLADISKLKWKCF----RTNNRNTTKCKEAIK----------ADLVLK-AYSLCISEN-------- 79   Strongyloides...
CCX07170       66 -NNCLWVFHIagitrvsagaeeGEilvDDEQPADEkderwlqieerlseewsLKESSRDIFHSS---SLTPPLQApltt- 140  Pyronema omph...
KDO54455       58 gFLSTWTNSFv-----------GP---WDPSQGLHnpdek--------iklwLFLPGRHSSVET---AQAAVSRLr---- 108  sweet orange
XP_011681830   62 -ILSVWRCHNtv--------raDLfagSETQIQSKel--------------wIYWYGDEPNFED---LIAPEIQDa---- 111  purple sea ur...
EUB64817       61 -LMCAWVRRKra--------stEP---HKPDIFSNfsk-----------elwVFWYGSDDPCTR---SRDRLISSdl--- 111  Echinococcus ...
EKM59526       92 -RVSLYLFAFgs--------tmDA---SAAQMPLSlgtrktr----hllqlkMLLCESGAVLYR---QSFTYISCvrvae 152  Phanerochaete...
EMD41184       94 -QSSLYVFAFgs--------taGV---SEGQAALE------------------ALQLHCLTSQE---TSFFTPSS----- 135  Gelatoporia s...
XP_003025901   98 sRSRIYVFRLga--------keAL---REMKTAMAk----------------LSFEGLEACIAL---DEIYGPTN----- 142  Schizophyllum...
KDQ65114       71 -RSTLHVFAFgs--------tlRT---TESHAALN------------------ALSFPGLSTSQ---SSSFTPHDly--- 114  Jaapia argill...
KZT66995       94 -SSALYVFAF------------GSsdrTSEAQGAL-----------------AALQFDDLARVE---SSTFQPSS----- 135  Daedalea quer...
XP_024510859   80 -YICLWRRIPse--------ddEN---DYPRGEFTlrsa---------kelwVFWFDKREPRNLasyTCDLVVRD----- 133  Strongyloides...
CCX07170      141 ---pfaaITIDP-------------MTTAPP--TPKtevidltlddeprpa----------------dppppetleerna 186  Pyronema omph...
KDO54455      109 -------VVASG-------------LWVAPG--DSEe------------------------------------------- 123  sweet orange
XP_011681830  112 -------VQAQG-------------VWDNCM--SYE-------------------------------------------- 125  purple sea ur...
EUB64817      112 ------eESSSG-------------NWGNGL--TYE-------------------------------------------- 126  Echinococcus ...
EKM59526      153 rngpctmGGPGLlahakrciqkfdtYSFTPD--GIYpcslscatqrvpcavciqqreassfatpssqasptcslprkplr 230  Phanerochaete...
EMD41184      136 -------LYPCS-------------AACSEL--PSPcsncpdivsadctta----------------sssgppllrkplr 177  Gelatoporia s...
XP_003025901  143 -------------------------SSTARI--PSKtt-----------------------------------------r 154  Schizophyllum...
KDQ65114      115 -----pcSTECS-------------VIPIPC--PTClnpsstpkssssvss---------------stsaacrlprhplr 159  Jaapia argill...
KZT66995      136 -------------------------VYPCSA--ACStqdipcseclnpahpr-------------vgsssahllprqslr 175  Daedalea quer...
XP_024510859  134 --------EYDA-------------DHQNQNdvVRYd------------------------------------------- 149  Strongyloides...
CCX07170      187 rIYRYLLTSVIGVLTFHL-------SLHSGFTP--LNARTLVapsslptliskttnngKDAGGKNDPLPFSHitapelat 257  Pyronema omph...
KDO54455      124 -VAAALSQALRNCIERAL--------NGLSYLR--FGDVFS-----------------KYQPSQSEESFRKG-------- 167  sweet orange
XP_011681830  126 -CRTLLFKSFHNSIERCL--------LSGGYVR--LGRWFV------------------KPFASYPIPGENL-------- 168  purple sea ur...
EUB64817      127 -TRCVLFKALHNVIERYL--------LKKGYVR--LGKWFL---------------------QPCNSQSIRD-------- 166  Echinococcus ...
EKM59526      231 lPLVQFIQAVRDRIIDDI-------VRSSSETSerWTGRLQGgfl----------lspLSPADDGEWGAEWE-------- 285  Phanerochaete...
EMD41184      178 lPFFQFLQAVRDRLVGDIcenskekANGRTAVK--LKDGFLL----------------SSSPASSEWGAGWE-------- 231  Gelatoporia s...
XP_003025901  155 tILSHFFEAIRTRFVDDVvrq--atNVKRDVQR--FKTGFLFgatvpm-----arstkEQQSTEDNWSAGWD-------- 217  Schizophyllum...
KDQ65114      160 aIYSQFLEAIRNKLINDLsestkktPESPPVRR--FKSGFLLg---------------PSNRGTYEWGEGWE-------- 214  Jaapia argill...
KZT66995      176 lPFYYLLNAVRDRLIDDIteasrhaRTHRPAIR--YKDGFLL----------------GPSPASSEWSAGWE-------- 229  Daedalea quer...
XP_024510859  150 -IRCLLFRAIHNLIERSL--------FTMGQKR--FGKWFVA----------------TGTKEELKQSMPQR-------- 194  Strongyloides...
CCX07170      258 pLVMELNAY-LTTVGTLL---It----pSST-KQQAIRRLGS-----SGYTDK-----------------SWVERECFIA 306  Pyronema omph...
KDO54455      168 -HPTIEFIFaATEEAIFIhalV------SAK-HIHSLSGGDMekgfkHSSSSS-----------------SSLRLPVIVS 222  sweet orange
XP_011681830  169 -SDHHSVSFsFFLHGEKT---Vcs--nvEVG-LHQPVCRLTAd----HLAIAQg----------------SATAVPVILS 221  purple sea ur...
EUB64817      167 -KTQYSINFsFFLHGEST---Vca--slDIR-RFPKFKSLTSr----ILSFCEk----------------SGGRFNVVLA 219  Echinococcus ...
EKM59526      286 -HYGRSRPF-VHCELQIS---Ls----qTRL-VILPILRTTQ-----YLPLTTsl--------------sLPTGTPIVLL 336  Phanerochaete...
EMD41184      232 -HHARTRPL-IYCHLQLH---LshappsSARlIIHPVLRPSY-----YLPLYNml--------------pLPSGTPMALL 287  Gelatoporia s...
XP_003025901  218 -AYASARPL-TFVHLDIQ---Ldar----lrlLINPIFRPTS-----HRPLPLptpfhrhsrtshashssLSAGIPITLL 283  Schizophyllum...
KDQ65114      215 -HHARSRPL-IYCSLQLH---Ls----pTQI-LIHPILRPTD-----LLPLPFhh-------------ptTPTGTPIALI 266  Jaapia argill...
KZT66995      230 -HPKPSRPL-IYSSLEVQ---LshhcsrAQL-LIHPVLRPTF-----YLPLCKts--------------pLPPGAPILLL 284  Daedalea quer...
XP_024510859  195 -NYSLAYGFsFFVHGDIM---Vca--tiNIQ-RQPLMCRLDL------LDYFS------------------KKSVPLILG 243  Strongyloides...
CCX07170      307 PWGEWGRIIPP-----------SESESSILPASESrW-------KESVTSYLKDHGIISPisleddkksVLQEaiekgTW 368  Pyronema omph...
KDO54455      223 PHGMRGRLTGYcptdlvkqvyfRTSNGCVGLPHVSqGsgcqlngQNCYVEVTMGCPRSGS----------DKAshinsNS 292  sweet orange
XP_011681830  222 PYGLSGFLTGQ-----------AYKSTHQTAQ-------------RILYEWKLFYPIKQQ----------QTSkgehdRH 267  purple sea ur...
EUB64817      220 PYGITAHLVVP-----------SHAYTNDGFVD------------KELESWKRFFPMRSPgen---yshPNSSahrnsFY 273  Echinococcus ...
EKM59526      337 PHGTPAFYLNTysgalgnlthqFEDALFGLGVGNWk---------SAPVNESTNSPCYLI------------------AW 389  Phanerochaete...
EMD41184      288 PYGVPAFYLSTysgpstalttqFEDSLVGLGAGD--Wkr----pCAISEQRLKPEHARSGc--------QNSSptfviAW 353  Gelatoporia s...
XP_003025901  284 PHGTAAHFLAEytpt---dsraLDREFEKGFRGTGvL-------FHTSISSSPQDHNAHI-----------PStpyiiGY 342  Schizophyllum...
KDQ65114      267 PYGTPAYYLTSytgptsglvnqFEQSLHGLGVGG--W-------TERCATNQDTGMPSAP----------SRTptfvvAW 327  Jaapia argill...
KZT66995      285 PYGVPAYYLST-----------YAGPTSALTSQFQdAl-----mGLGAGDWTGDGLSSAPrdd----srTIQSptyviAW 344  Daedalea quer...
XP_024510859  244 PHGIRATLVID-----------QIEYVKKEVVYISnKykrdilvAKQYNEIETIAEEQYN------------------DW 294  Strongyloides...
CCX07170      369 REIEIW-------------------LTNGDGTGNIHRIIWPESLLFIKHR 399  Pyronema omphalodes CBS 100304
KDO54455      293 LRNLHKhnvsesps----vgggdpkGSPDNMSAYEKTFIYPAEAVLVPVL 338  sweet orange
XP_011681830  268 HHHHHHhhhhhh-------nqhhphHYHPGYRDEEEDNTVPAVVEVHVGS 310  purple sea urchin
EUB64817      274 LDFLTPnk----------------sSPAQQQPQGSRSDVFSKRSS---AG 304  Echinococcus granulosus
EKM59526      390 VSVQNK-----------------------QGEEKGLPVIWPTTLSVLPDG 416  Phanerochaete carnosa HHB-10118-sp
EMD41184      354 LAVQNK-----------------------QGEEKGIPLIWPARLCITYHP 380  Gelatoporia subvermispora B
XP_003025901  343 LAIENR-----------------------HGEPKGLTFVYPRQLCLLSTD 369  Schizophyllum commune H4-8
KDQ65114      328 INIQNK-----------------------QGEDKGMTIIYPTHLCLTFHP 354  Jaapia argillacea MUCL 33604
KZT66995      345 LPVQNK-----------------------QGEDKGMPIIWPLRLCLSYHP 371  Daedalea quercina L-15889
XP_024510859  295 RGFYPLpvydaedikyriptvseilPRMTLVEIDNLKILWPTEYI----G 340  Strongyloides ratti
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