Conserved Protein Domain Family
Med3

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pfam11593: Med3 
Mediator complex subunit 3 fungal
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator subunit Hrs1/Med3 is a physical target for Cyc8-Tup1, a yeast transcriptional co-repressor.
Statistics
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PSSM-Id: 402954
View PSSM: pfam11593
Aligned: 3 rows
Threshold Bit Score: 312.095
Threshold Setting Gi: 74610965
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FXZ4        13 DVLTPSMSLTELEMKFADETD----------GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEerYANVSKQEKF 82  [Candida] glabr...
XP_003669925  11 KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--MPEKSQQEMF 88  Naumovozyma dai...
P40356         3 SIIPAGVKLDDLQVILAKNEN-----------ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQegSKQADRMAKY 71  Saccharomyces c...
Q6FXZ4        83 QMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKtyKNKN--FQVLENL---------ASYNHRGKA---GASISNST 148 [Candida] glabr...
XP_003669925  89 LSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTkkFHMLETLkpivepapaTAKATKGDAshsKKKSVAGT 166 Naumovozyma dai...
P40356        72 LHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKtaDNRDrsFQLLEPL---------STYNKNGNAvcsTATVVSTN 142 Saccharomyces c...
Q6FXZ4       149 PTPAAATPTTApTPGAGTKKAAKTAPTpta-----------------taTIGTPS--NNAPTPATTATTPGTQAKKPRKP 209 [Candida] glabr...
XP_003669925 167 PGSVGNTPVGT-TPGSSTGTVAANVPA----------------------NINANTtnTSTTSAASTTQTTSSTAKKPRKP 223 Naumovozyma dai...
P40356       143 HSAAASTPTTTaTPHANPITHAHSLSNpnstatmqhnplagkrgpksgsTMGTPTvhNSTAAAPIAA------PKKPRKP 216 Saccharomyces c...
Q6FXZ4       210 RQTKKqqqaaaaAAAVAQAQAQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQMQSP----IPANAMNNMNv 285 [Candida] glabr...
XP_003669925 224 RQNKK-------AAAKAQQQQQQQLLQQQQ------------------------------QQQIPkqqgIATNPMMNMN- 265 Naumovozyma dai...
P40356       217 RQTKKa-----kAQAQAQAQAQAQVYAQQS------------------------------TVQTP----ITA-------- 249 Saccharomyces c...
Q6FXZ4       286 phngAMrpsvpngnmgNPSMgNLNMNAPN--MGNPNMNnpnmnnpnaMMSPMAgQGQLNQMFPMQNHNQNGQFMGQQ--- 360 [Candida] glabr...
XP_003669925 266 ----AM----------NATP-MMNSVSPSnvMGTPLNN---------GISPMG-AVMAGGFYSQPPGSQSQQFDQQM--- 317 Naumovozyma dai...
P40356       250 ----SMaaa-----lpNPTPsMINSVSPTnvMGTPLTN---------MMSPMG------NAYSMGAQNQGGQVSMSQfng 305 Saccharomyces c...
Q6FXZ4       361 -SPGPNigqmqfppnNGNMNGMpgtsdmnlgmnpsmnmnmgMNLNQITPANILSMNTKGKDdqmqnigmdQNQNQNQSQN 439 [Candida] glabr...
XP_003669925 318 -NNGDH---------NTNNNNF-------------------QNMNNITPANILSMNTVGDP---------QSRMASSSQQ 359 Naumovozyma dai...
P40356       306 sGNGSNpn------tNTNSNNTplq--------------sqLNLNNLTPANILNMSmnn--------dfqQQQQQQQQQQ 357 Saccharomyces c...
Q6FXZ4       440 QSqnqnqsmnmnMNNDSNNpksaydLVDFNSLDLSSLNMDFL 481 [Candida] glabrata CBS 138
XP_003669925 360 YP----------TNNNNNN------TLDLNNLDLSSLNMDFL 385 Naumovozyma dairenensis CBS 421
P40356       358 QPqpqyn-mnmgMNNMNNGgke-ldSLDLNNLELGGLNMDFL 397 Saccharomyces cerevisiae S288C
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