Conserved Protein Domain Family
NEMO

pfam11577: NEMO (This model is not part of the current CDD release)

NF-kappa-B essential modulator NEMO

NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK.

Links

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Source:	pfam
Taxonomy:	Euteleostomi
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures

Statistics

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PSSM-Id:	519779
Aligned:	6 rows
Threshold Bit Score:	70.2597
Created:	15-Feb-2025
Updated:	28-Apr-2025

Structure

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PubMed References

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Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

5EOF_A        16 PEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHE 82  human
Q90Z16        37 PEEMVQQMKELITENNELKEAMKLHNQAMKDRYEELSIWREKQKEEREFYETKFKEAKQCLLAKCVE 103 chicken
XP_004913095  31 DAEMLEQIKQLLMENNNLKETMKQMNQEMKERLEELLKRHNQHLLDLNSENELLRKELNSLREKNAT 97 
Q8VC91        44 EQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLE 110 house mouse
XP_005162127  43 DLAGNEIVQKLITDNHQLREALKRSNDALKERCEEMEGWQRRSREEREFLSCRFREARELVQRLAQE 109
Q3ZC32        37 PHELLQQMRELLIENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERLYFETQSKEAKERLTALSLE 103 cattle

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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