5U0P


Conserved Protein Domain Family
Med27

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pfam11571: Med27 
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Mediator complex subunit 27
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.
Statistics
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PSSM-Id: 402942
View PSSM: pfam11571
Aligned: 43 rows
Threshold Bit Score: 76.9356
Threshold Setting Gi: 695009980
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U0P_2       173 FIFFHDTRGKFSVYCSSSKDDAITFSINr-NNNFLgNLWSLMPKILDYQHLYSKPCDFCKSLISpvyLE----LPSVRRN 247
Q10477       173 FIFFHDTRGKFSVYCSSSKDDAITFSINrnNNFLG-NLWSLMPKILDYQHLYSKPCDFCKSLI----SPvyleLPSVRRN 247 Schizosaccharom...
XP_002482680 279 pPEWRVSSRNSFGR-PSRLENAILHQLNs-RPRKW-DLCYLLEYVLSYSNIRSQPCKKCNHVTGs-lAQ----LPIVRKP 350 Talaromyces sti...
CAK46449     244 VPDWRVFTRTPGGQTPSKVETAVAQCLNs-RPRQW-DLLYLLDMISSYSTIKQTPCAKCTKMTDs-tAT----LPTIRKP 316 Aspergillus niger
GAD96507     241 gmGWRVSNKQSPGKPKTKLETSVSMSLNq-RPRKW-DLAYLLEMISSYSEIKKTPCVKCNKMIDn-tTL----LPTIRRS 313 Byssochlamys sp...
CBF79081     257 VPEFNVSSKSPSGEPSSRVETAVLACLNa-RPRKW-DLKFLFGMISSYSNIFQTTCTRCGKMQDq-aAN----LPTLRRP 329 Aspergillus nid...
Q4W9T3       242 MVDWRVQELAAPGRPKTKLETAVAACLNa-RPRQW-DLAYLLDMIASYSDVKQTPCVKCGKMTDn-aAQ----LPSVRRP 314 Aspergillus fum...
Q2U0Q4       275 VPEWQVSSRTMPGQVKTKLESAVSDCLNs-RSRQW-DLAYLLDMISSYSDVKQTPCVKCGRMTDn-aAQ----LPAVRQQ 347 Aspergillus oryzae
EAW13416     241 VSDWRVMDKAVPGKPKTKLELGIMACLNa-RPRQW-DLAHLLDMISAYSAVKQTPCAKCGKMTNs-aAQ----LPTIRQP 313 Aspergillus cla...
EPS30709     230 IVEWNVSKQPLPGRAPTKIEDSIVQCVNa-RPRKW-DLAFVIDMISSYSDMKQTVCVKCNKLTDs-sAQ----LPVIRRA 302 Penicillium oxa...
5U0P_2       248 ANs-----------------------TvkptskdILALHAEC 266
Q10477       248 ANstvk----------------ptskD-------ILALHAEC 266 Schizosaccharomyces pombe 972h-
XP_002482680 351 VAltsagdgsapaegsgngasnelgvV-------WEAYHQAC 385 Talaromyces stipitatus ATCC 10500
CAK46449     317 SStpqe----------------qgsqT-------WEAYHQGC 335 Aspergillus niger
GAD96507     314 KTvespd--------------gkkstT-------WEAYHQNC 334 Byssochlamys spectabilis No. 5
CBF79081     330 KTkepqt---------------dqppT-------FEAYHATC 349 Aspergillus nidulans FGSC A4
Q4W9T3       315 NPlqssq---------------gqpvL-------WEAYHPTC 334 Aspergillus fumigatus
Q2U0Q4       348 KQqsdp----------------qqppI-------WEAYHSSC 366 Aspergillus oryzae
EAW13416     314 KPtsdgq---------------esslQ-------WDAYHTDC 333 Aspergillus clavatus NRRL 1
EPS30709     303 QAipsaqq-------------epqglV-------FDALHASC 324 Penicillium oxalicum 114-2
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