Conserved Protein Domain Family
Med29

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pfam11568: Med29 
Mediator complex subunit 29
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.
Statistics
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PSSM-Id: 402941
View PSSM: pfam11568
Aligned: 24 rows
Threshold Bit Score: 158.227
Threshold Setting Gi: 269849670
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGT34724     315 MVQDPVDLVRNLVQKdLRNCLVEMNKRGAVLVKKR-FEGDSV-------LDEDKEQYKRSANDFDAVCDDVDRMLTTIME 386 Caenorhabditis ...
Q9DB91        51 QDFDPVQRYKMLIPQ-LKESLQTLMKVAAQNLIQN-TNIDNGqk----sSDAPLQRFDKCLEEFYALCDQLELCLRLAHE 124 house mouse
Q8JHI6        33 QDFDPVHRFKMLIPP-LKDSLQNVMTIASLNFAHN-TAIDNGlkttekgNDAAVQRFDKSLEEFYALCDQLELCLRLAHE 110 zebrafish
XP_018669516  77 QNKDPVHNAKAILPH-LKESLVNLMAVASQNFAVS-VSVDDMqk---vvDASNVPRFDKCLEHFYNLCDQLELQLNLGHH 151 vase tunicate
3_pfamImport   1 QNKDPVQKAKALLPH-LKESLVNLMAVASQNFAVS-VAVDDMqk---svDTSSVPRFDKCLEHFFSLCDQLEVQLNLGHH 75 
XP_783567     59 QEHDAIAKVKMTVVL-LKEALRNLMKISAQAFAHS-ATIDNTtk----tSDEIAARFDKSLEEFYSLCDQLELSLRLAYD 132 purple sea urchin
Q60YF6       322 MVQDPVDLVRNLVQKdLRMSVVEMNKRGAELLHQK-EEGAIK--------EEDRQQYKRATNDFHAVCDEIDRTLTTIME 392 Caenorhabditis ...
EFO86856     343 MVQDPVDLVRNLVQKdLRNSVVEMNKRGADLVRQR-EEKNVN--------ESDRAQFKRAANDFHAVCDEIDRTLTTVME 413 Caenorhabditis ...
2_pfamImport   1 MVQDPVDLVRNLVQKdLRNSLVEMNRRGAVLVRQReEEGEIS--------QEDKQQYKRAANDFNAVCDEIDRTLTTVME 72 
XP_015790079  15 pKYDNIARVKTLVWS-LKQSVQGLIKISAAYISHN-AAVDSGlk---apDDKVLPAFDKAFEDFHSLLNQIELHFKTIQE 89  two-spotted spi...
EGT34724     387 TAKQLSKlekvfnerTLRDQDGE----VMVNQVQTFVDNTDiVQKMFDDTINNVTATMEKVRRREKKWEDLQKEQQQ 459 Caenorhabditis bre...
Q9DB91       125 CLSQSCD--------SAKHSPTL----VPTATKPDAVQPDS---LPYPQYLAVIKAQITCAKDIHTALLDCANKVTG 186 house mouse
Q8JHI6       111 CLSQSID--------STKHSPNL----VPTATKPDTVQTES---LSYSQYLSMIKSQISCAKDIHNALLECSKKIAG 172 zebrafish
XP_018669516 152 QLSQALA--------SIQHTPLM----RNVNLKDDANGPQI-----YGNYINTVESQLQCAEEIQNLLLNCCKKLQE 211 vase tunicate
3_pfamImport  76 QLSQALV--------STQNTPFM----RNVVLKENPNGAQL-----YGSYVNTVESQLHCVKEIHDLLSNCCKKLQE 135
XP_783567    133 CTTQFMD--------GARYTPVP----LVHSHKPDMMPTEA---LTYGQYISTVKAQIQCASDVHTALLDCCQKLGH 194 purple sea urchin
Q60YF6       393 TAKQITKldkvfqdrTSKEIDGE----AMVNSVQKFVDETGiVQKMFDDTVNSVTSTMEKMRRRQKKWKDQQQQQEN 465 Caenorhabditis bri...
EFO86856     414 TAKQLIKlekvfmdrNSKELDGE----LMVNSVQSFVDNTDiVQKMFDETIGGVTASMEKMRRRQKKWEDLQKETQN 486 Caenorhabditis rem...
2_pfamImport  73 TAKQLSKldkvfierSTKELDGE----VMVNCVQKFVDNTEiVQKMFDGTIGNVTATMEKIRRREKKWEDLQRKKKE 145
XP_015790079  90 CAIQQRQ--------SQKYLPGPdkykAGPPKTEPYMDSGSdHELPYNQYIHLIRGQLSFVESLQKILLDGSRKIEl 158 two-spotted spider...
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