Conserved Protein Domain Family
PI31_Prot_N
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pfam11566: PI31_Prot_N (This model is not part of the current CDD release)
PI31 proteasome regulator N-terminal
PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces. This is the N-terminal domain of the members.
Links
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Statistics
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PSSM-Id: 519773
Aligned: 94 rows
Threshold Bit Score: 76.1694
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009220096   27 ATSDLSGSYEALALFTHACMACL-DFRLIG---------LTEGQKRagdd--dnnECrrlaprLPPGWNAsFNSYSFVYA 94 
Q5ZJL3         11 ARAGISCPQDALVCGIHWELIQH-GYRCLG---------AGEQpgpe----erksEL------LPAGWEAnKEVYTLRYK 70  chicken
10_pfamImport   1 VAPDLSCPQDALVCYLHWKLITH-GYRCLG---------AGDQpgas----erksEM------LPPGWNAdKELYTLRYR 60 
Q17LA8         16 VQPSIQTKSDVLIAVVHWYLIKN-SFRNVG---------LGDDKTLsesd--eksEL------LPEGWNSnPHSYALRYV 77  yellow fever m...
XP_002027630   51 IRRSIRKKADLLLALAHFLVTKQyHLRSVdpehgqgirmSAGSRLIpvdpgrggsEL------LPMHWNReSSKYRLHYV 124
XP_015033729   30 VNSDVHKKADLLIALVHFVLTKHySFRCLG---------IGDDKTLpeeeaesgsEL------LPDDWNSdDAKFSLRYV 94 
XP_015024279   28 VDGIIDKKADVLMVLAHFLLTKHyKFRCVG---------IGDDKTLpede--vgsEL------LPDHWNGdSSKYSLRYV 90 
13_pfamImport   1 VEKDVTRNTDIIVVMVHWFLTKNsSFRCIG---------IGDDRTVteqd--tgsEL------LPASWNDsSERYTLRYV 63 
Q7QJC6         22 ESANLADKADAMMLFVHWFLVRN-GFRNVG---------VGDDKTLnnav--dqsEL------LPEGWNGnNKSYALRYI 83  Anopheles gamb...
Q9V637         23 VKADVSKKSDLLIALVHFLLTKHyNFRCVG---------VGDDKTLpee---egsEL------LPDSWNDdDTKYSLRYV 84  fruit fly

XP_009220096   95 HAQSAMTFVTKVDRMGQRAEVRGIASATDAVVRFDVAPRDYVSSAAlpvritlrkkstpagggggggggsgdattttttt 174
Q5ZJL3         71 STDDARELLLKAIVVEDSMILNVMDRASQKVTDVTLAVADYINPEH---------------------------------- 116 chicken
10_pfamImport  61 AKDDSRDLLLKGIMVDGSIILNVMEPKSQKVADLTLKVTDYINPEH---------------------------------- 106
Q17LA8         78 NNGQl--YILHGIDSEGTMIVNLLQVKTLNVSNTTFQIEDTVKALK---------------------------------- 121 yellow fever m...
XP_002027630  125 DELDHQ-YVLLARLTHQDLVINLQNWTSKRMSITCLQPEDLVQTLH---------------------------------- 169
XP_015033729   95 NNKTl--YLLLGHMTEDALLINLLDTNTKKVSNICIEPENLVIELK---------------------------------- 138
XP_015024279   91 HNKVl--YLLLGHITEDALIVNLLDINTKNVSNICITPESLVAEVK---------------------------------- 134
13_pfamImport  64 SDKIl--YILIGTHSANTFLINLLNTRTEKVSNVALKPNDIVKSLN---------------------------------- 107
Q7QJC6         84 MNNEl--YILHGTLSNDTMIVNLLQAQSLQVSNAAFNLDKTITSFN---------------------------------- 127 Anopheles gamb...
Q9V637         85 HDKMl--YLLLGHITEGSLLINLLDINTKKVSNICVEPETLVPEVK---------------------------------- 128 fruit fly

XP_009220096  175 dsnngstddgggggedrtdlpakLGAVFVSPERIADLASLVKVSIVQRLAPGIAKD 230
Q5ZJL3        117 -----------------------LNDFHKVYKNMEELRTRIVSGIIAPLGVPTEKA 149 chicken
10_pfamImport 107 -----------------------LADFDKVYQNTEELQAQILHHIVSPFETAAK-- 137
Q17LA8        122 ------------------------GSITTLIPEAATVLDRIRRELLVPVFESNKKD 153 yellow fever mosquito
XP_002027630  170 -----------------------NSDLGQCIPTAHQVMHHLRVYLVNPVVRGRRKg 202
XP_015033729  139 ------------------------GPLTNMIPTVSEIVDRFRKELLEPVFSGNSKE 170
XP_015024279  135 ------------------------GGITKIMPTATDIVERFRKELCDPVFTGNSRE 166
13_pfamImport 108 ------------------------GSIQNMVPSITYLMDRFRKELVKPVFTGTSRD 139
Q7QJC6        128 -----------------------DSNLTNVVVSIDDQITRLQTELIKPLCDGGSKS 160 Anopheles gambiae str. PEST
Q9V637        129 ------------------------GGITTIMPSASEIVERYRRELLDPVFTGNSRE 160 fruit fly
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