Conserved Protein Domain Family
PI31_Prot_N

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pfam11566: PI31_Prot_N 
PI31 proteasome regulator N-terminal
PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces. This is the N-terminal domain of the members.
Statistics
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PSSM-Id: 402939
View PSSM: pfam11566
Aligned: 99 rows
Threshold Bit Score: 75.7819
Threshold Setting Gi: 195173710
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EJT78951      27 ATSDLSGSYEALALFTHACMACL-DFRLIG----------LTEGQKRagdd--dnnECrrlaprLPPGWNAsFNSYSFVY 93  Gaeumannomyces ...
Q17LA8        16 VQPSIQTKSDVLIAVVHWYLIKN-SFRNVG----------LGDDKTLsesd--eksEL------LPEGWNSnPHSYALRY 76  yellow fever mo...
XP_002027630  51 IRRSIRKKADLLLALAHFLVTKQyHLRSVdpehg-qgirmSAGSRLIpvdpgrggsEL------LPMHWNReSSKYRLHY 123 Drosophila pers...
Q9W466        50 IQSHIRKKSDLLIAVTHFLITKEyRLRCAInysasdgrqlAGGCGTVc--------EQ------LPDHWNRdADRYTLNY 115 fruit fly
KRF98601      30 VNSDVHKKADLLIALVHFVLTKHySFRCLG----------IGDDKTLpeeeaesgsEL------LPDDWNSdDAKFSLRY 93  Drosophila will...
XP_016027068  23 VKADVSKKSDLLIALVHFLLTKHyNFRCVG----------IGDDKTLpee---egsEL------LPDSWNDdDTKYSLRY 83  Drosophila simu...
KRF78440      28 VDGIIDKKADVLMVLAHFLLTKHyKFRCVG----------IGDDKTLpede--vgsEL------LPDHWNGdSSKYSLRY 89  Drosophila virilis
1_pfamImport   1 VEKDVTRNTDIIVVMVHWFLTKNsSFRCIG----------IGDDRTVteqd--tgsEL------LPASWNDsSERYTLRY 62 
Q7QJC6        22 ESANLADKADAMMLFVHWFLVRN-GFRNVG----------VGDDKTLnnav--dqsEL------LPEGWNGnNKSYALRY 82  Anopheles gambi...
XP_011435000  13 IKSQIKTSQDALIAVLHWELISK-GFKCLG----------NGEESSdtst--eqgsES------LPTGWNSsPSFYAMRY 73  Pacific oyster
EJT78951      94 AHAQSAMT-FVTKVDRMGQRAEVRGIASATDAVVRFDVAPRDYVSSAAlpvritlrkkstpagggggggggsgdattttt 172 Gaeumannomyces ...
Q17LA8        77 VNNGQl---YILHGIDSEGTMIVNLLQVKTLNVSNTTFQIEDTVKALK-------------------------------- 121 yellow fever mo...
XP_002027630 124 VDELDHQ--YVLLARLTHQDLVINLQNWTSKRMSITCLQPEDLVQTLH-------------------------------- 169 Drosophila pers...
Q9W466       116 TDGLAGQ--YILMAKLSRRDLVISLQNSTSKRMAIVCLQPEHLVNSTC-------------------------------- 161 fruit fly
KRF98601      94 VNNKTl---YLLLGHMTEDALLINLLDTNTKKVSNICIEPENLVIELK-------------------------------- 138 Drosophila will...
XP_016027068  84 VHDKMl---YLLLGHITEGSLLINLLDINTKKVSNICVEPETLVPEVK-------------------------------- 128 Drosophila simu...
KRF78440      90 VHNKVl---YLLLGHITEDALIVNLLDINTKNVSNICITPESLVAEVK-------------------------------- 134 Drosophila virilis
1_pfamImport  63 VSDKIl---YILIGTHSANTFLINLLNTRTEKVSNVALKPNDIVKSLN-------------------------------- 107
Q7QJC6        83 IMNNEl---YILHGTLSNDTMIVNLLQAQSLQVSNAAFNLDKTITSFN-------------------------------- 127 Anopheles gambi...
XP_011435000  74 SSKAEKDSvYILKVIQIEDDFLVHFMKKGTEAVESLNVRTADYTTGSV-------------------------------- 121 Pacific oyster
EJT78951     173 ttdsnngstddgggggedrtdlpakLGAVFVSPERIADLASLVKVSIVQRLAPGIAKD 230 Gaeumannomyces tritici R3-111a-1
Q17LA8       122 --------------------------GSITTLIPEAATVLDRIRRELLVPVFESNKKD 153 yellow fever mosquito
XP_002027630 170 -------------------------NSDLGQCIPTAHQVMHHLRVYLVNPVVRGRRKg 202 Drosophila persimilis
Q9W466       162 -------------------------KSSMDKCIPRLDKFIKRLRAELVDPAVRGTKRl 194 fruit fly
KRF98601     139 --------------------------GPLTNMIPTVSEIVDRFRKELLEPVFSGNSKE 170 Drosophila willistoni
XP_016027068 129 --------------------------GGITTIMPSASEIVERYRRELLDPVFTGNSRE 160 Drosophila simulans
KRF78440     135 --------------------------GGITKIMPTATDIVERFRKELCDPVFTGNSRE 166 Drosophila virilis
1_pfamImport 108 --------------------------GSIQNMVPSITYLMDRFRKELVKPVFTGTSRD 139
Q7QJC6       128 -------------------------DSNLTNVVVSIDDQITRLQTELIKPLCDGGSKS 160 Anopheles gambiae str. PEST
XP_011435000 122 --------------------------ESYDRTYKNLDELCALFKSSIVDPVLKPQNtt 153 Pacific oyster
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