Conserved Protein Domain Family
ADIP

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pfam11559: ADIP (This model is not part of the current CDD release)
Afadin- and alpha -actinin-Binding
This family is found in mammals where it is localised at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.
Statistics
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PSSM-Id: 519771
Aligned: 19 rows
Threshold Bit Score: 105.09
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001384912   14 RHASDLINSMLLSRAYTDQKIQFTTIdwddlirdqvldneevpkinelkvtEKLYENDRATINIIHSLLVALDRNRGQQK 93  
XP_001486607   10 RNAADLINSTLLSKGYVDEKLYFNTIdwshllsdq-------pqqvslettDVVYNNDKNIINIVFSLLKSIERNKAQNQ 82  
Q6C1M1          2 EAAAEFINHTLVSKGYLLSDRLKFATvsk-------------------tplENVEENDMLVINTIYSLLQSLEKDSKAEE 62   Yarrowia lipo...
Q9P6R4         14 EESLLYINKSLFSKGVIQAEKLRLSH---------------------------DIRDNCNIVNIIYRLLRATDEERLEKE 66   Schizosacchar...
Q245H7         90 ANDLKQINDALQSYGYNRIGNLFEVS----------------------------NDNIEQAINTIRSLLQQRQRDLEFRQ 141  Tetrahymena t...
A0BKF3         49 QNQIKNIREKLIMMGFPSLGDLYSNS----------------------------NSEVDLTVKVLVAVIKQRREDMDFKN 100  Paramecium te...
XP_958669       8 RTASIYINNQLLSRGLLRDGDTIDFAypg-------------------dndDELAHTMGRIMGVVNDLILRRDRDAETRE 68  
Q0CWV7          7 QAASTYINNVLLARGLLKNGRPIDFAepe-------------------neeGGTGATMGRIINLVNDLVLRRDREAEHRE 67   Aspergillus t...
Q4WAP1          7 QAASTYINNVLLARGLVKSGRPIDFAqpe-------------------nddGGVEGTMARIINLINDLVLRRDREAEHRE 67   Aspergillus f...
Q5KLN4         35 SAELTTINSQLMSHGWAKRPLNLDAL---------------------------SQKDYNEVVAVLFELMGASVSNLNMLE 87   Cryptococcus ...
XP_001384912   94 LSNQTIHQKDATIESLKSRISLLETQLAQSENKVDkLVHFDQNELNKRITDLSRHNKIQAQDLNKLRNWAGDIKTKYRVE 173 
XP_001486607   83 AFNRQLSQKDATIANLNKKIDQLTTQVSQQQMQISkLYQFDHTQLNKKVQSLTQINKLQSQDLNRLNNWCKDIKTKYGVE 162 
Q6C1M1         63 NRLRRVADLEHDNDRLRNEIRALHRKNHDLHTRLA-HEENALQNAKREIARLEAAAKNERGSLTRAKMAVDRFKQQSMVE 141  Yarrowia lipo...
Q9P6R4         67 SLLDAIKNNEYEKQRDNNTIKRLKNELELYQNECQ-LQLNKVRTLERDQAELITQNKGLKDVNAKNELTLKALKNQLSVS 145  Schizosacchar...
Q245H7        142 LHHETAKRDQNDIAQMHNAIEKLQIRNKQLQTELD-VVNQKLKNQERDYRDEKEKLNSQLRDITLQYSKIVNRETQFNNE 220  Tetrahymena t...
A0BKF3        101 TYHERVNKIEAEKQQLVSNFERVSNNRKILEQENT-TLQAKIKSTEKVQKEQINKLMLEREDLQKQLSKLQSRSTQFEHE 179  Paramecium te...
XP_958669      69 SLSQTLRSLRAESLRQSTDIVRLSDKLTDSARKTA-LAEQETAHARAQLKAAEQTVARLKEEAARQKSLVQQTRNACANE 147 
Q0CWV7         68 NLATTIRALRTEDSQKTVEIEKLKAKASELTRALA-LAEAQERSLKSNVAHTDATIRGLKEQVQRMKTTIQQVRAQCAND 146  Aspergillus t...
Q4WAP1         68 NLATTIRTLRAEDSQKMLEIEKLKTKTSELARSLA-LAEAQERALKTNLSSTEATIRGLKEQIQRMKANVQQIRAQCAND 146  Aspergillus f...
Q5KLN4         88 TLNGRHRTLEYEYERLQKTTNSLKTSNARLESEVA-GWKSKCADIEKRLVLEEIKTKELREENSRGRKALETVRVAATHE 166  Cryptococcus ...
XP_001384912  174 LKKKTLEISELKNKLLE 190 
XP_001486607  163 IRRRNIEITSLKSKLLE 179 
Q6C1M1        142 MRKRDVRLERMRELARK 158  Yarrowia lipolytica
Q9P6R4        146 LRQHEQQMETLKGNYGL 162  Schizosaccharomyces pombe 972h-
Q245H7        221 FRKKDTMIKQLQDQIKK 237  Tetrahymena thermophila SB210
A0BKF3        180 LKQRDLEIQKLKDHIKK 196  Paramecium tetraurelia
XP_958669     148 IRKRDRMIEGLKKAVAD 164 
Q0CWV7        147 IRKRDLEMQRLKSHLSD 163  Aspergillus terreus NIH2624
Q4WAP1        147 VRKRDLEMQKLKSHLAE 163  Aspergillus fumigatus
Q5KLN4        167 TKKVQMSLDKAHAQLAK 183  Cryptococcus neoformans
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