Conserved Protein Domain Family
Inhibitor_Mig-6
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pfam11555: Inhibitor_Mig-6 (This model is not part of the current CDD release)
EGFR receptor inhibitor Mig-6
When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.
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Statistics
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PSSM-Id: 519768
Aligned: 6 rows
Threshold Bit Score: 68.8482
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_022534394  800 PPQIPPRDPLSQPGSRTPSPMGLHVGSHCSP-----------------ASIYG---SSY-----------LSSSPGKLMP 848 
5_pfamImport    1 RPPQIPPRDPLSQPNSRTPSPNCAVVGSLQQricsv-------spsthQASHS---YSS-----------HLSTSPGKPM 59  
1_pfamImport    1 QPPRIPPRDPLSQPGSRTPSPM--AHHTSC------------------PPAHT---YGS-----------YLSSSPGKLM 46  
4_pfamImport    1 RPPQIPPRDPLSQPGSRTPSPMGLVVGSPQQrlysvspntmqaaittcPPTHT---YSS-----------YLSTSPGKLM 66  
XP_029686603  869 QPPQVPPRDPLSQPGSRTPSPRGPVVGS-----------------------PHqwvYSVsptamqapagsYLSTSPGKLM 925  torafugu
XP_015146945  844 RPPQIPPRDPLSQPTSRTPSPMALQVGSPQQ-----------------RAA-----LCS-----------CLSTSPGKPM 890  chicken

XP_022534394  849 TTQSFASDPKYAAPKVILAQGKDKE 873 
5_pfamImport   60 PTTHSFASDPKYAAPKVIQAQGRDN 84  
1_pfamImport   47 PTTHSFASDPKYAAPKVIQAQGHGR 71  
4_pfamImport   67 PTTHSFASDPKYAAPKVIQAQVQGK 91  
XP_029686603  926 PTTHSFASDPKYAAPKVIQAQGKEA 950  torafugu
XP_015146945  891 PTTQSFALDPKYATPKVIQAQGKDC 915  chicken
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