Conserved Protein Domain Family
Sec31
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pfam11549: Sec31 
Protein transport protein SEC31
Sec31 is involved in COPII coat formation as it forms through the sequential binding of three cytoplasmic proteins: Sar1, Sec23/24 and Sec13/31. Sec13/31 is recruited by the pre-budding complex and polymerization of Sec13/31 occurs to form an octahedral cage that is the outer shell of the COPII coat. Sec13/31 is a hetero-tetramer which is organized as a linear array of alpha-solenoid and beta-propeller domains to form a rod in which twenty-four copies assemble to form the COPII cub-octahedron.
Links
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Statistics
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PSSM-Id: 431930
Aligned: 12 rows
Threshold Bit Score: 81.8066
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004181275  938 PPPQNGKsgASGQTPHLNKKANFGWNDLPIgkDATQaKPSRAKAVSIQPSNS 989 
XP_002555972  931 APPASNA--ASGQTPHLNKNANDGWNDLPL--NVKE-KPTRAKAVSVAPVSV 977 
Q6FNU4        893 APPVKSPsvYSGQTPHLNKKANDGWNDLAL--PVKE-KPQRAKPVTVAPSPI 941  Nakaseomyces glabratus CBS 138
XP_003680336  894 PPPTV----ASGQTPSLNRKANDGWNDLPL--PVKE-KPSRAKAGSVAPVKI 938 
XP_022462968  915 PPPTMGAggLSGQAPHLNRKANDGWNDLPL--KVREkKPARAKPVSVAPMvn 964 
Q6CL75        876 PPPISGAsgYSGQTPHLHDKPIDGWNDLPS--VSKE-KPTRAKAVNTAPIGM 924  Kluyveromyces lactis NRRL Y-1140
XP_003667688  934 PPVPSHM--HSGQSPHLNRKANDGWNDLPI--KIEA-KPSRAKAVSVAKTgv 980 
XP_003959876  875 SAPPMNRgmQSGQKPHLNKKANDGWNDLPL--KVKE-KTSRAKAVSVAPVAV 923 
XP_001646415  894 NPVPGNV--ISGQVPHANKKANDGWNDLPL--DVRE-KTIRAKPVSVAPVSS 940 
Q75A30        893 PVNPAATnvLSGQSPHLNRKANNGWNDLPE--IVKE-KKSRAKPVSTAPVAV 941  Eremothecium gossypii ATCC 10895
XP_003683822  942 PPPI-NM--RSGQIPHLTKEANDGWNDLPL--KSKD-KPSRAKAVAVAPVAp 987 
XP_001643767  908 PPPITNV--KSGQTPHLNKDANDGWNDLPL--KSKE-KPSRAKPVAVSPAAS 954
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