4HTI,2QT7


Conserved Protein Domain Family
Receptor_IA-2

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pfam11548: Receptor_IA-2 
Protein-tyrosine phosphatase receptor IA-2
IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism.
Statistics
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PSSM-Id: 402927
View PSSM: pfam11548
Aligned: 26 rows
Threshold Bit Score: 123.875
Threshold Setting Gi: 946592134
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4HTI_A                 9 EARGYIVTDRDPLR-PEEGRRLVEDVARLLQVPsSAFADVEVLGPAVTFKVSA-NVQNVTTEDVEKATVD---NKDKLEE 83   human
Q7Q404                78 TEYAHVILKNPIDN-WKDGSRIVAALAELLNMQ-GYFTHPRVDRHEVSFRVEA-NPDRKTAADVAKQINDs-rFKNNLSR 153  Anophe...
EEB18641             462 EDYAYVILKNKVNT-WQEGSRIVRKVEELLDLPqNTFTNIRVDQNSVKFKIDS-NRLNLNASETIKKIDS---MKDSIQR 536  human ...
XP_012549515         421 PAYAYVLLKNGLLTnWAKGISFISKIEEMLGLDkNSFSNPRVDLREVTFKVEK-NNKGYDAVDVARRVDD---IKDDLLR 496  domest...
XP_015839035         493 TDYVYVEFENDVYK-WAEGKQLIGNISDLLGLErSAFSHGRVDHNEVTFKVEP-NNKGWNSTQVAEQIGK---IKDTLRE 567  red fl...
EFN86315             526 LDYVYIEFEQEFHK-WLEGEHVVAKVGELLDLPpGTLKDIRVGRAEVTFKVVP-NFKNYNATDVAENIGN---IRGKLKE 600  Jerdon...
XP_022534986         487 DLYGYIITDTDALP-TDQGLHLMELVAHRAKIQmTDFLELSVVGPAVTFQVRP-NSKNVTTTDVANVAVH---QKTALEK 561  Mexica...
NP_001122139         515 GDFGYIITE-DSLS-TDQGLNLMEILAERVRLHvTDFLQLSVLGPAVTFRLRP-NARNISTAQLARVAVE---QKGQLEK 588  zebrafish
WGS:AAPU:GI21996-PB  540 TEYAHVFVKNPIDS-WYDGQRIMNELAQILHMQ-GYFSYLTVQPHEVSFRVDSnNPERKTAADVARYINEnrgVKNNIQR 617  Drosop...
XP_028289753         536 RHFGYIITGSDSLT-SDQGSDLMERLTQRLNLHvTDLTQLSVLGPALTFRVGP-NPKNISTADLVQVAVQ---EKQQLEK 610  blunt-...
4HTI_A                84 TSGLKILQTGVGSK 97   human
Q7Q404               154 RLGVLVIQAGVGDK 167  Anopheles gambiae str. PEST
EEB18641             537 ATGIEIVSTKVGNQ 550  human body louse
XP_012549515         497 ETGAQIISTGVGDR 510  domestic silkworm
XP_015839035         568 VTGIVITAAGIGDK 581  red flour beetle
EFN86315             601 TLGVKVIRAGIGDK 614  Jerdon's jumping ant
XP_022534986         562 EASITIVEAGVTDR 575  Mexican tetra
NP_001122139         589 ESGLRILEAGLSDR 602  zebrafish
WGS:AAPU:GI21996-PB  618 RVGFYVLHAGVGDR 631  Drosophila mojavensis
XP_028289753         611 ETGLKIVEAGVSDR 624  blunt-snouted clingfish
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