2QT7,4HTI


Conserved Protein Domain Family
Receptor_IA-2

?
pfam11548: Receptor_IA-2 (This model is not part of the current CDD release)
Protein-tyrosine phosphatase receptor IA-2
IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism.
Statistics
?
PSSM-Id: 519764
Aligned: 21 rows
Threshold Bit Score: 122.746
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2QT7_A                 2 EEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRH-NEQNLSLADVTQQAGL---VKSELEAQ 77   human
WGS:AAPU:GI21996-PB  540 TEYAHVFVKNPIDSWYDGQRIMNELAQILHMQ-GYFSYLTVQPHEVSFRVDSnNPERKTAADVARYINEnrgVKNNIQRR 618 
XP_002431379         462 EDYAYVILKNKVNTWQEGSRIVRKVEELLDLPQNTFTNIRVDQNSVKFKIDS-NRLNLNASETIKKIDS---MKDSIQRA 537 
XP_008198101         493 TDYVYVEFENDVYKWAEGKQLIGNISDLLGLERSAFSHGRVDHNEVTFKVEP-NNKGWNSTQVAEQIGK---IKDTLREV 568 
EFN86315             526 LDYVYIEFEQEFHKWLEGEHVVAKVGELLDLPPGTLKDIRVGRAEVTFKVVP-NFKNYNATDVAENIGN---IRGKLKET 601 
Q60673               469 EEYGYIVTDQKPLSLVAGVRLLEILAEHVHMSSGSFINISVVGPAVTFRIRH-NEQNLSLADVTQQAGL---VKSELEAQ 544  house ...
XP_006636860         418 EEYGYIVTDQKPLSLFDGVRLLETLAERIHLTTSSFINISVVGPALTYRIRQ-NNHNLSAEDVADKAVA---EKTFLESE 493 
XP_023191229         488 DVFGYVITDTDRLQTDEGLHLMEILAHRANIQMTDFAELLVVGPAVTFKVSR-NSQNVSTADVANVAVK---QKADLEKE 563 
6_pfamImport           1 DLYGYIITDTDALPTDQGLHLMELVAHRAKIQMTDFLELSVVGPAVTFQVRP-NSKNVTTTDVANVAVH---QKTALEKE 76  
XP_011609116         433 EEYGYIFTNQSLLTLYDGVKLLGLLADRIHLSTSSFINISVVGPAVTFRLRQ-NEHNVTAAEVAAKAVS---EKHFLESE 508  torafugu
2QT7_A                78 TGLQILQTGVGQR 90   human
WGS:AAPU:GI21996-PB  619 VGFYVLHAGVGDR 631 
XP_002431379         538 TGIEIVSTKVGNQ 550 
XP_008198101         569 TGIVITAAGIGDK 581 
EFN86315             602 LGVKVIRAGIGDK 614 
Q60673               545 TGLQILQTGVGQR 557  house mouse
XP_006636860         494 TGLKILQTGVGER 506 
XP_023191229         564 TKLTILEAGVADG 576 
6_pfamImport          77 ASITIVEAGVTDR 89  
XP_011609116         509 TGLKIVQSGVGER 521  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap