pfam11545: HemeBinding_Shp (This model is not part of the current CDD release)
Cell surface heme-binding protein Shp
Shp is part of a complex which functions in heme uptake in Streptococcus pyogenes. During which, Shp transfers its heme to HtsA which is a component of an ABC transporter. The heme binding region of Shp contains an immunoglobulin-like beta-sandwich fold and has a unique heme-iron coordination with the axial ligands being two methionine residues from the same Shp molecule. Surrounding the heme pocket, there is a negative surface which may serve as a docking interface for heme transfer.
Jiyao W et al.(2023). "The conserved domain database in 2023.",