2PJH


Conserved Protein Domain Family
UN_NPL4
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pfam11543: UN_NPL4 (This model is not part of the current CDD release)
Nuclear pore localisation protein NPL4
Npl4 is part of the heterodimer UN along with Ufd1 which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a ubiquitin-like domain which has within its structure a beta-grasp fold with a helical insert.
Links
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Statistics
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PSSM-Id: 519762
Aligned: 7 rows
Threshold Bit Score: 88.6942
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2PJH_A         1 MAeSIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNN-GFSVYINRNKTGEITASSSKSLHLLKIKHGDLL-FLF 78  house mouse
EDO29888       1 MA-NLIIRVQSCEGTIRVKTSSGETLSTFLSKVAEQLSIPKR-GWSVYTDRSKSTRIESSSRKTVASVPLKHGDMV-YLF 77 
Q7ZVI8         1 MAeSIIVRIQSPDGMKKISSTKHETAAAFLKKVAKEFGFSSN-GFSVYLNRNKTGEIL-SQNKALSLLKIKHGDML-FLY 77  zebrafish
Q4N4S7         1 MVgEMILRVKSKIGISRLELSEDSTVGDLKNKIKERIQFTNNsQLKLYIEYNHQHLL--EDEVRLSEIGVVHGTSL-VLD 77  Theileria parva
Q5CYK6         2 MHeEWIIRVFSSSGRSRVTIPSTCNLSMLKSKIAQSLKVPEE-QQLLSLDSHGNTLL--------------KGDSLsVLQ 66  Cryptosporidium...
1_pfamImport   1 V-----LRIQSADGTKRIETEPSSTTKTLYELVREVCGFNHY-EFALFRERNFTKEVVSSGSQEVKDVGLKHGDIL-YLR 73 
Q9VBP9        32 K--QSLIRVQSAEGIKRIEISPKSNLKHLYDSVQNALKVD---GFGLFKERNFLTELQASGSQLVG-TSLRHGDMV-YLK 104 fruit fly

2PJH_A        79 PS 80  house mouse
EDO29888      78 KT 79 
Q7ZVI8        78 PS 79  zebrafish
Q4N4S7        78 NG 79  Theileria parva
Q5CYK6        67 HG 68  Cryptosporidium parvum
1_pfamImport  74 LV 75 
Q9VBP9       105 QM 106 fruit fly
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