Conserved Protein Domain Family
Dynein_IC2
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pfam11540: Dynein_IC2 (This model is not part of the current CDD release)
Cytoplasmic dynein 1 intermediate chain 2
Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolyzing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.
Links
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Statistics
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PSSM-Id: 519761
Aligned: 15 rows
Threshold Bit Score: 34.6359
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004359310  99 KYKPTLSIQNlVIEFDIPPREIPTYTKATQTP 130
1_pfamImport   1 KQPQELQVVF-VQSTDIPPKETVIYTKQTQTT 31 
XP_975764    105 KRAPNLSVVQ-VQSTNIPPKETVLYTKQTQTT 135
XP_049546378 101 KKPVNLCLVS-VQATNIPPKETVSYSKQTQTN 131
XP_015794556 101 KKPISLALVN-VNEINIPPKESVTYNKQTQTT 131
P54703        96 YIRPTLTIQSlVIEHDFPPKEIPMYSKGTQTM 127 Dictyostelium discoideum
XP_018655040  97 KKRKRLGFSQ-INEINVPPKENISYSKITQTF 127
NP_001073459 126 CRMQRLGASK-IVQIDFMPKELVTYSKETQTP 156
3_pfamImport   1 RRMQRLGASK-ITLVDFPPKEMVFYCKETQTP 31 
XP_029700590 109 RRMQRLGASK-ITQVDFLPREMVSYSKETQTP 139 torafugu
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