2OPE


Conserved Protein Domain Family
Pilin_PilX

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pfam11530: Pilin_PilX (This model is not part of the current CDD release)
Minor type IV pilin, PilX
PilX is a protein from Neisseria meningitidis which is crucial for the formation of bacterial aggregates and adhesion to human cells. The structure of PilX is similar to all pilins as it has the common alpha/beta roll fold. PilX subunits have surface-exposed motifs which are thought to stabilise bacterial aggregates against pilus retraction. It also illustrates how a minor pilus component can modulate the virulence properties of pili which have a simple composition and structure.
Statistics
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PSSM-Id: 519755
Aligned: 3 rows
Threshold Bit Score: 270.417
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2OPE_A   2 SEFEKGYQSQLYTEMVGINNISKQFILKNPLDDNQTIKSKLERFVSGYKMNPKIAEKYNVSVHFVNKEKPRAYSLVGVPK 81  Neisseria meningitidis
Q9JZV0  36 SYIEKGYQSQLYTEMVGINNISKQFILKNPLDDNQTIENKLEIFVSGYKMNPKIAKKYSVSVKFVDKEKSRAYRLVGVPK 115 Neisseria meningitidi...
Q5F9E2  36 SYIEKGYQSQLYTEMVGINNVLKQFILKNPQDDNDTLKSKLKIFVSGYKMNPKIAKKYSVSVRFVDAEKPRAYRLVGVPN 115 Neisseria gonorrhoeae...
2OPE_A  82 TGTGYTLSVWMNSVGDGYKCRDAASARAHLETLSSDVGCEAFSNRKK 128 Neisseria meningitidis
Q9JZV0 116 AGTGYTLSVWMNSVGDGYKCRDAASAQAHLETLSSDVGCEAFSNRKK 162 Neisseria meningitidis serogroup B
Q5F9E2 116 AGTGYTLSVWMNSVGDGYKCRDATSAQAYSDTLSADSGCEAFSNRKK 162 Neisseria gonorrhoeae FA 1090
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