4OI4


Conserved Protein Domain Family
Pfc11_Clp1_ID
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pfam11526: Pfc11_Clp1_ID 
Pcf11, Clp1-interaction domain
Pcf11 is a subunit and an essential component of the cleavage and polyadenylation factor CFIA from yeast and the orthologue from human CFII which is involved in pre-mRNA 3' end processing and in transcription termination. Pcf11-mediated termination is essential for vertebrate development. Pcf11 binds to Clp1, another subunit of CFIA/CFII, whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery. This entry represents the Clp1-interaction region (Clp1 ID) of Pcf11 from yeast and vertebrates.
Links
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Statistics
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PSSM-Id: 491924
Aligned: 35 rows
Threshold Bit Score: 53.5428
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OI4_B         20 LNTTTTRKNIQSRNWYLSDSQWAAFKD-DEITSTKHKNDYTD 60   Saccharomyces cerevisiae S288C
O94913       1370 RTEKDVSRKVTHRRWYYSLTDWIEFEE-IADLEERAKSQFFE 1410 human
XP_009026445  867 KIEKTGSKSLKYRSWYPDLMEWIQLND-NNIVTSDYKPTDTN 907 
XP_015700831  500 QRMTEATKRGQSRSWYLDEREWINSLE-CDDDIGPTNEGTTS 540 
Q2GNV2        490 QRMTDAEKRGQHRSWYVDESDWIHTRE-AIDTDYTHPPQDPS 530  Chaetomium globosum CBS 148.51
XP_002838317  475 QRMAESVKRGQNRSWYLGEEEWIKSRD-DGEDSSSLAPNPNS 515 
XP_001523973  453 KKQSVKGGNIQSRNWFLDDYDWVQFDE-DSLSEYASVNNSNG 493 
XP_002614710  438 KRSTNHKANIQSRTWYISQDEWVHFDE-SSLSEQAAAPVARA 478 
XP_036662978  381 KKLTVKGGNIQSRDWYVDDYEWVKLSE-NKVGEQADSTTATD 421 
XP_045284290  294 QRMTEASKRGQSRSWYLDEREWIKSREfDDDTGGPTGDSATS 335
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