Conserved Protein Domain Family
TFIIE-A_C
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pfam11521: TFIIE-A_C (This model is not part of the current CDD release)
C-terminal general transcription factor TFIIE alpha
TFIIE is compiled of two subunits, alpha and beta. This family of proteins are the C terminal domain of the alpha subunit of the protein which is the largest subunit and contains several functional domains which are important for basal transcription and cell growth. The C terminal end of the protein binds directly to the amino-terminal PH domain of p62/Tfb1 (of IIH) which is involved in the recruitment of the general transcription factor IIH to the transcription preinitiation complex. P53 competes for the same binding site as TFIIE alpha which shows their structural similarity. Like p53, TFIIE alpha 336-439 can activate transcription in vivo.
Links
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Statistics
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PSSM-Id: 519750
Aligned: 23 rows
Threshold Bit Score: 69.2975
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_790549    342 NESDASASDDEYSQPQGRTEPPLsedrlafgtmmgdvtmgrHEEEEEEEE--DMIVMVQGRPVPLDEVT--PEMISEMDQ 417
EEC00493     332 DSSDSEDGHGNSKTSVSSHVFSPpdalstmpeqtqdaqseeEDDDEEEEE---TQVMVEGVPVALQHVTe--EMVSRMTP 406
EDO37785     342 SSSSDSDSEKASNATAPTHDKVTdfm-------------daADSDDEEEE---HKIKVNGKVVALGDVTd--DMMKLMSP 403
Q2LZ72       349 NSSDSSDDEKDIDNAKIPDLDFEny--------------snSDSEEEADD--VPTVSVAGRPHPLDQLDd--KLIAQMTP 410 Drosophila pseu...
XP_002068111 350 SDANSSDDEKEISNAKKPDLDSEddn------------yinSDSGDDGDD--VPTVLVAGRPQPLDQIDd--KLIAQMTP 413
3_pfamImport   1 ESSDSSDNESKDPYKLKDELAAva----------------eMESDDSDSDdnAPSVMVNGKTVPLTSVDd--DVIAQMTP 62 
XP_012957280 341 SGSDTSE-SEDAKHSGTALTKVGg----------------sNFE-EEEQEalNPVLMVAGQPYSYSEVSenPELVSLMTN 402
5_pfamImport   1 SQSDSSEFEEDAKHSRGAGTKVId----------------sNFEQEEEQEtqGPILMVAGQPCSYGQVSenPELVSLMTN 64 
8_pfamImport   1 SYSDNSGFEEDAKHSRGEGMKVAg----------------sNFEQEEEQEtlDPILMVAGQPCFYGEVSenPELVSLMTN 64 
XP_006006478 339 SGSDPSESEGETKKKKVEVTRPEn----------------aETEQEDEEE--DPTVMVAGQPHLCSEVSqhPDLVSFMTE 400 coelacanth

XP_790549    418 EEKDEYIRLAQQAHADMYE 436
EEC00493     407 AEKEDYIRLRQELYSMMYD 425
EDO37785     404 EEEEAYHKAFEQAYSHMY- 421
Q2LZ72       411 QEKENYIHVYQQHYSHIYD 429 Drosophila pseudoobscura
XP_002068111 414 QEKENYIHVYQQHYSHIYD 432
3_pfamImport  63 TEKETYIQIYQEYYSHMYD 81 
XP_012957280 403 EEREAYIKVGQEMFQSVFE 421
5_pfamImport  65 EERNAYIKVGQEMFQSVFE 83 
8_pfamImport  65 EERDAYIKVGQEIFQSVFE 83 
XP_006006478 401 GEREVYIRVSQQMFQSMYD 419 coelacanth
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