Conserved Protein Domain Family
Activator_LAG-3
?
pfam11498: Activator_LAG-3 
Transcriptional activator LAG-3
The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1. Its N-terminal region adopts an elongated kinked helix that is required for complex assembly.
Links
?
Statistics
?
PSSM-Id: 151935
Aligned: 2 rows
Threshold Bit Score: 423.99
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q09260        23 MKPSTSK---TTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHL 99  Caenorhabditis ...
XP_002641477   1 MKPSTSKagsSAQSPPPEEPNSAYVNNELPDPDDEPLVSEMTVYNKGQEEARLRSQEAYEKFQKTRQESISSQRAVTAQL 80 

Q09260       100 FNRYTEDEERKRVEQQKNKEAMNASTSapTSSRNGgqSVENRKRRNDvvVAPPTSEEEWKRA-QQQHWMGQQQPQM-QFQ 177 Caenorhabditis ...
XP_002641477  81 YHRFTEDEERKRMEHQKNKEAMNASVA--SASRNG--HIDNRKRRND--VGSLSAEEEWRRAqQQQHWMGQAAPMHpSYQ 154

Q09260       178 MQQQYHsQQQqyimMQQQHHHMTgmqqihhqmpstssadSIRSVPTPaSSMHQPSPAEMRNGCgmsrnatmdmtcspmsg 257 Caenorhabditis ...
XP_002641477 155 MQQQYH-QQQ----VAAQHHQFM----------------APHSVPTP-GSIHRPSPSGMQSVC----------------- 195

Q09260       258 gQPIVDENNLAVPEGEWFDKLALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNgdrmpSTAPPPaQNPQ 337 Caenorhabditis ...
XP_002641477 196 -LPTSDENSLDVPNGEWFDKLAVMVAEKYDATTILGPDTYDVYLNELDAMEPVGETVKTPSEAG-----QSASQP-MNPQ 268

Q09260       338 HiAQLQQQQNKMRLMQQQQQemqrIEQQRRQQIMQQQQQQqqqeHQRQQMLLqQQQQQQQMQQHHQMNgGGQFaTQAHQQ 417 Caenorhabditis ...
XP_002641477 269 Q-QQMAQQQNKMRMLQQQEM----MEQQRQQQMMHQHQQQ----HRQQQMLL-QQQQMHQLQQQNQMN-GGQF-TQAQQH 336

Q09260       418 AAYMQQMQRM---EQIRHQQQQAQQHQQAqQQHQQQAQHHQMGYGIPNGYpQQMHMHPPaYGaHHMPQPTAFANIN 490 Caenorhabditis elegans
XP_002641477 337 AVYLQRMQHMrlqQQQQQQQQQAQHHQQA-QQHQQPHQNGVMGYSVPNGY-AHPNGYAP-YG-HHMPHHTPFANIN 408
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap