3HGQ


Conserved Protein Domain Family
HDA2-3

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pfam11496: HDA2-3 
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Class II histone deacetylase complex subunits 2 and 3
This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 (coiled-coil quantitatively-enriched protein 1). These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus.
Statistics
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PSSM-Id: 402894
View PSSM: pfam11496
Aligned: 21 rows
Threshold Bit Score: 233.758
Threshold Setting Gi: 149240852
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HGQ_C         21 NTSGDYWLPTTXSLYQKELTDQIVSLHYSDILRYF--------------ETSHYKEDVIL-----------------ESX 69   baker's yeast
Q5AU22        562 LGPSEFAVPLPMDSRVKDDYERVLEESKNALEVSLsg----------rkEIPESELQLERa----------------ALL 615  Aspergillus n...
CAL00849      464 LGPSEFAVPLPMDSRVKDDYERVLTSESQSIRDFL--------------GVTSSQPDTT------------------EYQ 511  Aspergillus n...
Q0CE08        132 LGPAEFCVPLPMDSRVKDDYERVLTNESHTIRDFL-------------------NESL-------------------TTK 173  Aspergillus t...
Q2UA49        139 LGPSEFAVPLPMDSRVKDDYERVLVDETQGIRNFL--------------RGSSSSGMSNGhde------------rlVLK 192  Aspergillus o...
Q4WEL1        373 LGPSEFAVPLPMDSRVKDDYERILKDEAQSIDEFL--------------KTFALQAETSRieq-----------erlIPR 427  Aspergillus f...
Q6CTS2          6 NRTQVFYIPVGLTQVQKDLLEILISIHAESFVSCVdkrllpelqsklekKGTNLKRDLSMtal------------tdVQL 73   Kluyveromyces...
XP_001487224   42 SNDGVHYLPTVLTPMQRDICEIIIQIMRHHLTNGVesrrtra-sinsllETAESSEGIASss-------------dsYDM 107  Meyerozyma gu...
XP_001526238   92 NSSGVYHIPTQLSKLQIALTKILLHLISEPLINQSiskekkkntidsllEVSTMQSTLSLspdnghqnandggsrdlYKL 171  Lodderomyces ...
ABN64578       47 HESSIYYLPTVLTRLQKELAEVVVQLFSTDLVGEVrskrsrtsidslleSVTNSSNSLSS-----------------FDK 109  Scheffersomyc...
3HGQ_C         70 KTXCL-NGSLVATHPYL-LIDHYXPKSLITRDVPAHLAENSGKFSVLRDLINLVQEYE---------------------- 125  baker's yeast
Q5AU22        616 IQQVLeRLSNAATHPDInVADHMESAESKFEQEASWADYSSAKFLLLNYLIKAASEHD---------------------- 673  Aspergillus n...
CAL00849      512 MHDILdRLSNISTHPDLnIAEH-INSESDLGREAAWAEYSSAKFLLLSYLLETASMRD---------------------- 568  Aspergillus n...
Q0CE08        174 IREILsHLSNVATHPDLnIAEHIKDSDSDFAKEAAWAEYSSAKFLFLGYLVEFASSRD---------------------- 231  Aspergillus t...
Q2UA49        193 MREILgSLSNVATHPDLnIAEHIKDSDSDLGKEAAWAEYSSAKFLFLGYLVEIASNRD---------------------- 250  Aspergillus o...
Q4WEL1        428 MNSLLeRLSNTSTHPDLnITEHIKDSDSDLAKEAAWAEYSSAKFLLLGYLINNASSHD---------------------- 485  Aspergillus f...
Q6CTS2         74 TEWFFeNIRAVSNHPCL-LVEHYMPRQFLLMEPTERLIYTSDKFGKLNLMVDLLLNRKdks------------------- 133  Kluyveromyces...
XP_001487224  108 IKLLFdQLCIASRHPSL-LVDHLMPKQLLLLETNERLLNLSGNLKLFNEIIDGIIDSLrdst------------------ 168  Meyerozyma gu...
XP_001526238  172 FAFCFeKLCVINNHPSL-LVDHFMPRKLLLSEPNELQISMSGKLELFNKIVDGIIDAHrhrsrndrdqekeeekkkekeq 250  Lodderomyces ...
ABN64578      110 VTLLFdQLSIINNHPSL-LVDHFMPKKLLLSDVSERLVAMSGKFHLFNRIVDSLIESEhgp------------------- 169  Scheffersomyc...
3HGQ_C        126 --------------TETAIVCRPGRTXDLLEALLLGNKVHIKRYDGHSIKSAAAAND----------------------- 168  baker's yeast
Q5AU22        674 --------------IHLVIMVRGEKTQGIVERYLQGKGFSYTRSREEMGSGTNAEVS----------------------- 716  Aspergillus n...
CAL00849      569 --------------IHLVIMVQGEKTQRVVERYLMGKGLLYTRPRQEMGSGTNIEVS----------------------- 611  Aspergillus n...
Q0CE08        232 --------------IHLVIMVNGERTQKVVERYLMGKGLVYTRPRGEMGLGTNLEVS----------------------- 274  Aspergillus t...
Q2UA49        251 --------------IHLVIMVQGEKTQKVVERYLIGKGLIYTRPREEMGSGTNLEVS----------------------- 293  Aspergillus o...
Q4WEL1        486 --------------LHLVIMVHGAKTLKILERFLMGKGLSYTRPRHEMGIGTNLEVS----------------------- 528  Aspergillus f...
Q6CTS2        134 ------------rpLQVAIISHSVKELDLIEGVMLGKVAKLKRLSGTSLFDEKHEYDdqtsgsrttngenssssgsvap- 200  Kluyveromyces...
XP_001487224  169 ----------ktevFNILVIAENVKELELVEGIIIGKQLYYKNLSSGKMYEDNRGMPlseqkevepksk----------- 227  Meyerozyma gu...
XP_001526238  251 rknkektqgkqkqlVSILVVAKSNKELELIEGMIIGKDLQYHNSSNMRLYDDKRKRPflrkkddkergraggadehennd 330  Lodderomyces ...
ABN64578      170 ------------ggFHVLVVAQSVKEIELIEGLIIGKRIYYNNFSNAKLYNDNRGIPdfhnp------------------ 219  Scheffersomyc...
3HGQ_C        169 ----------------------FSCTVHLFSSEGINFTK---YPIKSKARF-DXLICLDTTVDTSQKDIQYLLQYKRERK 222  baker's yeast
Q5AU22        717 ------------------------LAKDALSFGVQLAQS---DGIVNVYKApSAIIALDSSLNTKNPSVEHMRTTFARNG 769  Aspergillus n...
CAL00849      612 ------------------------MVKDSLSFGIQTTRN---DGVMETYKPpAAIIALDKSFSSKTPTVEHMRTTFARNG 664  Aspergillus n...
Q0CE08        275 ------------------------MVKGSLSLGIQSTQS---DGVLETYKApSAIIALDSSFNPKSPPVEHMRTTFARQG 327  Aspergillus t...
Q2UA49        294 ------------------------LVKGSLSLGIQSTLS---EGITETYKSpSAIIALDSSLNVKSPSVEHMRTTFARHG 346  Aspergillus o...
Q4WEL1        529 ------------------------MVKESLSFGIQSTID---DGIMETYKPpAAIVALDSSFNATSPSVEHMRTTYARHG 581  Aspergillus f...
Q6CTS2        201 -eqigkskdeynysksrrknniSQLDWLFLATTTHLTHS---EDLLSRYNL-DLIISFDPMLDESLPSIFKVRKNGRK-- 273  Kluyveromyces...
XP_001487224  228 ----------rrrfsskgpqtgSAATCLYLTTTQQFYNHytpASLSGNSAF-NLIFSFDQTIDCESPSIEVSRNVHNNGR 296  Meyerozyma gu...
XP_001526238  331 dsdndgddndnddndqhhdkgvHASLFINLIQTRQLYNNymnLSTSSIGNY-KFIFSFDFDIDPSNPSIEMLRLSHN--- 406  Lodderomyces ...
ABN64578      220 -----------------knkklKDKVCLYLVTSQQLYNNyvpSSGNDNSKF-NLIFSFDIKLDVTSPSVELLRGDTEE-- 279  Scheffersomyc...
3HGQ_C        223 GleryAPIVRLVAINSIDHCRLFFGkkfdknsreyLENVTAAXVILRDRLGTLPPDLRPiYSQKLHYLVEWL 294  baker's yeast
Q5AU22        770 Hl---LPIIRLMVANSSEHVELCYPgpst---pkhLSKILQYSEHLRDIVGDLQDDALGvHED-ANEIMTCL 834  Aspergillus nidulans
CAL00849      665 Nl---LPVVRLLVSNSSEHIELCFPglse---perLRTVLQYSIRLRDVVGDLQDDALGvQED-AEELLSCL 729  Aspergillus niger
Q0CE08        328 Tl---LPAIRLVVSNSSEHVELCFSnlpd--ireaLRTTIQYTIRLQDMVGDLQDDALGvQED-VEEILSFL 393  Aspergillus terreus N...
Q2UA49        347 Nl---LPIIRLIVSNSSEHIELCFPdppe---lqrLQLIVQYTVRLRNIVGDLQDDALGvRED-VEEILPWL 411  Aspergillus oryzae
Q4WEL1        582 Nl---LPVIRLLVSNSSEHVQLCFAnype---phrLRLVVQYTSRLRDVVGDLQDDALGvYED-SEEILSSL 646  Aspergillus fumigatus
Q6CTS2        274 -----TPLFKLLVQDSPDHYLLSKKkptttsekliL-----------------------------DSIVHFL 311  Kluyveromyces lactis
XP_001487224  297 K----TPILIPVPVMSILHILTQIPkpagnlgnisIDRLLS-----------------PaHKWRLRALNVYA 347  Meyerozyma guilliermo...
XP_001526238  407 -----CPIYVPVPIFSIEHLKLCIPep------rhS---------------NFDDGGDElHRWRLKVLNTMV 452  Lodderomyces elongisp...
ABN64578      280 -----TPIYIAVPVFSIEHVQLQFPepr----pslNYE---------------KDTSNPlFKWKLQVINAFI 327  Scheffersomyces stipi...
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