Conserved Protein Domain Family
Lge1

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pfam11488: Lge1 (491900 is an unknown moldel)
Transcriptional regulatory protein LGE1
This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.
Statistics
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PSSM-Id: 491900
Aligned: 37 rows
Threshold Bit Score: 45.3245
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UUI2        66 SPYHYRVPSNNstrasfgaASTDtnvelpKinlpdsSLSSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYRE 145 Schizosaccharom...
XP_002493789 152 SYWVARLKI-D--------GQLR------E------KIQTSFESLESTDDRTRNLLQKSLALEIEADNLARFVENEALRV 210
NP_001102462 320 DGTEMYEDSQL--------SSRS------K------AIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQ 379
ELW48705     108 DGIELFEDGQL--------TNRS------K------AIGLKTKEREQAYQQGCETFGMVVKILIEKDSSLEKPIQFALRQ 167
XP_024897038 274 DGIELFEDGRL--------SSRY------K------AIAAKTKMIEQVYQQDCETFAMVVKMLVEKDPSLEKPIQFALRQ 333
XP_008109317 289 GDNELFEDTQR--------VRRA------K------AIAAKTTEIEQVYKQDCETFGAVVKMLIEKDPSLEKSIQFSLRQ 348
XP_005993234 275 ELLRPIEESKA--------DHRS------A------VIAAKTKEIEQVYKQDCETFGMVVKMLIDKDPSLEKPIQFALKE 334
XP_007579001 263 EDSKKSTENLE--------ERRT------M------AIAAKAKEIEKVYRQDCETFGMVVKMLVAKDPSLEKQLQVPLRE 322
XP_015459981 253 EDPEQTAE-----------AHRA------H------VIANKALEIEKLYRQDCETFGMVVKMLVAKQPTLEKQLETALKE 309
XP_003496748 332 ERTELVDDQLT---------NRL------K------AIASKTKEIEQAYHQDCETFGMVVKMLVDKDPSLEKSIQFALRQ 390
Q9UUI2       146 GLRSda--avKSLNDFV 160 Schizosaccharomyces pombe 972h-
XP_002493789 211 KLCE------EKLENIN 221
NP_001102462 380 NLHEigercvEELKHFI 396
ELW48705     168 NLHEmgerciEELKHFI 184
XP_024897038 334 NLYEmgqrcvEELKHFI 350
XP_008109317 349 NLHEigerciEELKHFI 365
XP_005993234 335 NLNDigdrciEELKRFI 351
XP_007579001 323 NLGEirerclEDLKHFI 339
XP_015459981 310 NLVEikerclEDLRQFI 326
XP_003496748 391 NLHEisercvKELRQFI 407
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