2AL3


Conserved Protein Domain Family
TUG-UBL1
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pfam11470: TUG-UBL1 (This model is not part of the current CDD release)
TUG ubiquitin-like domain
TUG is a GLUT4 regulating protein and functions to retain membrane vesicles containing GLUT4 intracellularly. TUG releases the GLUT4 containing vesicles to the cellular exocytic machinery in response to insulin stimulation which allows translocation to the plasma membrane. TUG has an N-terminal ubiquitin-like domain (UBL1) which in similar proteins appears to participate in protein-protein interactions. The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site. This domain is also found at the N-terminus of yeast UBX4.
Links
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Statistics
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PSSM-Id: 519721
Aligned: 91 rows
Threshold Bit Score: 50.5829
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AL3_A        15 LAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFnp--sEYDLK-FQRTVLDLSLQWRFANLPNNAKLEM 78  house mouse
XP_020427834   6 ILYKNDKTVVQFTPNTFLSEILKKGCTQFKLad-vsLYALT-HNQKPVNLSLPFRLSGIPNSSRVTI 70 
XP_003285467   7 IIYKSGKFTVPVIASNSMLEVFKKGCQHFKLnd--sSHQLM-YGNTNVNLSLPYRLSGIPNLSRVTI 70 
Q54X06         6 IIYKTGKTTVPVIASTVMMEVLKKACQYFKIdd--sRFQLM-YGSTYVNLSLPFRLSGIPNLSRVTI 69  Dictyostelium discoideum AX4
XP_002637083   7 ICPNAKRVQVKTTPMMLIRQVLEEACLKSGFev--nRHRLQtQSRKPIDPSLPFRLSGIPNNATLEM 71 
CBJ49238       8 ILHGGHRKVTRIGANDSMSTVVQMACREFGLdtgspNWVLK-HKRVVVDLSQPFRFTGIPQNATLEL 73 
ETN64984      14 RAMNNRQYTVPVAPNMTFYDILKNVCQKTNLep--aEHVLS-FRTRLQDSSLMFRFSGIPNKAMLDM 77 
XP_002073397   8 LMPNGRRQNVSVSANMTLLEILETSCKKHGFds--eEHCLK-FHNKPVSLTQQFRFSGLPNNCVLEM 71 
XP_026695531   8 LCLSGRRRTVKFTPNFTIVQILEEVCKKENLdp--aCHELR-NGRSVVDRSLPWRYTNLPNNAKLEL 71  vase tunicate
XP_048576050  10 VCPNARRQTVKVGPTTTILQILEEVCKKQGYts--qDYAIK-HQRKIVDETLPVRYSGLSNNAHLEL 73  starlet sea anemone
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